Progress of Middle East respiratory syndrome coronavirus vaccines: a patent review.
Identifieur interne : 001925 ( Ncbi/Curation ); précédent : 001924; suivant : 001926Progress of Middle East respiratory syndrome coronavirus vaccines: a patent review.
Auteurs : Jiwon Choi [Corée du Sud] ; Mi-Gyeong Kim [Corée du Sud] ; Yu-Kyoung Oh [Corée du Sud] ; Young Bong Kim [Corée du Sud]Source :
- Expert opinion on therapeutic patents [ 1744-7674 ] ; 2017.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Animaux, Anticorps neutralisants (immunologie), Brevets comme sujet, Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Humains, Infections à coronavirus (), Infections à coronavirus (immunologie), Lymphocytes T (immunologie), Souris, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie).
- MESH :
- administration et posologie : Adjuvants immunologiques, Vaccins antiviraux.
- immunologie : Anticorps neutralisants, Coronavirus du syndrome respiratoire du Moyen-Orient, Infections à coronavirus, Lymphocytes T, Vaccins antiviraux.
- Animaux, Brevets comme sujet, Humains, Infections à coronavirus, Souris.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Animals, Antibodies, Neutralizing (immunology), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Humans, Mice, Middle East Respiratory Syndrome Coronavirus (immunology), Patents as Topic, T-Lymphocytes (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Viral Vaccines.
- chemical , immunology : Antibodies, Neutralizing, Viral Vaccines.
- immunology : Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, T-Lymphocytes.
- prevention & control : Coronavirus Infections.
- Animals, Humans, Mice, Patents as Topic.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a new pathogen, causing severe complications and a high case fatality rate. No direct treatments are available as yet, highlighting the importance of prevention through suitable vaccination regimes. The viral spike (S) protein has been characterized as a key target antigen for vaccines. In particular, S protein domains have been utilized to produce high titers of neutralizing antibodies. Areas covered: Since the first report of MERS-CoV infection, a limited number of MERS-CoV-specific patents have been filed. Patents related to MERS-CoV are categorized into three areas: treatments, antibodies, and vaccines (receptor-related). This review mainly focuses on the types and efficacies of vaccines, briefly covering treatments and antibodies against the virus. MERS-CoV vaccine forms and delivery systems, together with comparable development strategies against SARS-CoV are additionally addressed. Expert opinion: Vaccines must be combined with delivery systems, administration routes, and adjuvants to maximize T-cell responses as well as neutralizing antibody production. High immune responses require further study in animal models, such as human receptor-expressing mice, non-human primates, and camels. Such a consideration of integrated actions should contribute to the rapid development of vaccines against MERS-CoV and related coronaviruses.
DOI: 10.1080/13543776.2017.1281248
PubMed: 28121202
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pubmed:28121202Le document en format XML
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a new pathogen, causing severe complications and a high case fatality rate. No direct treatments are available as yet, highlighting the importance of prevention through suitable vaccination regimes. The viral spike (S) protein has been characterized as a key target antigen for vaccines. In particular, S protein domains have been utilized to produce high titers of neutralizing antibodies. Areas covered: Since the first report of MERS-CoV infection, a limited number of MERS-CoV-specific patents have been filed. Patents related to MERS-CoV are categorized into three areas: treatments, antibodies, and vaccines (receptor-related). This review mainly focuses on the types and efficacies of vaccines, briefly covering treatments and antibodies against the virus. MERS-CoV vaccine forms and delivery systems, together with comparable development strategies against SARS-CoV are additionally addressed. Expert opinion: Vaccines must be combined with delivery systems, administration routes, and adjuvants to maximize T-cell responses as well as neutralizing antibody production. High immune responses require further study in animal models, such as human receptor-expressing mice, non-human primates, and camels. Such a consideration of integrated actions should contribute to the rapid development of vaccines against MERS-CoV and related coronaviruses.</div>
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