MersV1, Ncbi, Curation, bibRecord, 000C44

Antisense oligodeoxynucleotides provide insight into mechanism of translation initiation of two Sendai virus mRNAs.

Identifieur interne : 000C44 ( Ncbi/Curation ); précédent : 000C43; suivant : 000C45

Antisense oligodeoxynucleotides provide insight into mechanism of translation initiation of two Sendai virus mRNAs.

Auteurs : K C Gupta

Source :

The Journal of biological chemistry [ 0021-9258 ] ; 1987.

RBID : pubmed:2438279

Descripteurs français

KwdFr :
- ARN (génétique), ARN antisens, ARN messager (génétique), Animaux, Biosynthèse des protéines, Cellules cultivées, Embryon de poulet, Endonucleases, Oligodésoxyribonucléotides, Relation structure-activité, Single-Strand Specific DNA and RNA Endonucleases, Séquence nucléotidique, Virus parainfluenza humain de type 1 (génétique).
MESH :
- génétique : ARN, ARN messager, Virus parainfluenza humain de type 1.
- ARN antisens, Animaux, Biosynthèse des protéines, Cellules cultivées, Embryon de poulet, Endonucleases, Oligodésoxyribonucléotides, Relation structure-activité, Single-Strand Specific DNA and RNA Endonucleases, Séquence nucléotidique.

English descriptors

KwdEn :
- Animals, Base Sequence, Cells, Cultured, Chick Embryo, Endonucleases, Oligodeoxyribonucleotides, Parainfluenza Virus 1, Human (genetics), Protein Biosynthesis, RNA (genetics), RNA, Antisense, RNA, Messenger (genetics), Single-Strand Specific DNA and RNA Endonucleases, Structure-Activity Relationship.
MESH :
- chemical , genetics : RNA, RNA, Messenger.
- chemical : Endonucleases, Oligodeoxyribonucleotides, RNA, Antisense, Single-Strand Specific DNA and RNA Endonucleases.
- genetics : Parainfluenza Virus 1, Human.
- Animals, Base Sequence, Cells, Cultured, Chick Embryo, Protein Biosynthesis, Structure-Activity Relationship.

Abstract

Translation of Sendai virus nucleocapsid protein (NP) and phosphoprotein (P/C) mRNAs in rabbit reticulocyte lysates in the presence of antisense oligodeoxynucleotides (15-20-mers) showed that oligonucleotides having complementarity within the 5' noncoding region of the mRNAs blocked translation, oligonucleotides having complementarity within 20 nucleotides upstream from the initiator codon blocked translation only partially, and oligonucleotides complementary to the coding region of mRNA had no effect on translation. The results suggest the possibility that the 80 S initiation complex may form about 20 bases upstream from the initiator codon. Alternatively, the 40 S preinitiation complex may recognize an initiator codon at least 20 nucleotides upstream from the codon, activating a helix-destabilizing process.

PubMed: 2438279

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pubmed:2438279

Le document en format XML

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<author><name sortKey="Gupta, K C" sort="Gupta, K C" uniqKey="Gupta K" first="K C" last="Gupta">K C Gupta</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Antisense oligodeoxynucleotides provide insight into mechanism of translation initiation of two Sendai virus mRNAs.</title>
<author><name sortKey="Gupta, K C" sort="Gupta, K C" uniqKey="Gupta K" first="K C" last="Gupta">K C Gupta</name>
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<series><title level="j">The Journal of biological chemistry</title>
<idno type="ISSN">0021-9258</idno>
<imprint><date when="1987" type="published">1987</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Base Sequence</term>
<term>Cells, Cultured</term>
<term>Chick Embryo</term>
<term>Endonucleases</term>
<term>Oligodeoxyribonucleotides</term>
<term>Parainfluenza Virus 1, Human (genetics)</term>
<term>Protein Biosynthesis</term>
<term>RNA (genetics)</term>
<term>RNA, Antisense</term>
<term>RNA, Messenger (genetics)</term>
<term>Single-Strand Specific DNA and RNA Endonucleases</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN (génétique)</term>
<term>ARN antisens</term>
<term>ARN messager (génétique)</term>
<term>Animaux</term>
<term>Biosynthèse des protéines</term>
<term>Cellules cultivées</term>
<term>Embryon de poulet</term>
<term>Endonucleases</term>
<term>Oligodésoxyribonucléotides</term>
<term>Relation structure-activité</term>
<term>Single-Strand Specific DNA and RNA Endonucleases</term>
<term>Séquence nucléotidique</term>
<term>Virus parainfluenza humain de type 1 (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Endonucleases</term>
<term>Oligodeoxyribonucleotides</term>
<term>RNA, Antisense</term>
<term>Single-Strand Specific DNA and RNA Endonucleases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parainfluenza Virus 1, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN</term>
<term>ARN messager</term>
<term>Virus parainfluenza humain de type 1</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Base Sequence</term>
<term>Cells, Cultured</term>
<term>Chick Embryo</term>
<term>Protein Biosynthesis</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ARN antisens</term>
<term>Animaux</term>
<term>Biosynthèse des protéines</term>
<term>Cellules cultivées</term>
<term>Embryon de poulet</term>
<term>Endonucleases</term>
<term>Oligodésoxyribonucléotides</term>
<term>Relation structure-activité</term>
<term>Single-Strand Specific DNA and RNA Endonucleases</term>
<term>Séquence nucléotidique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Translation of Sendai virus nucleocapsid protein (NP) and phosphoprotein (P/C) mRNAs in rabbit reticulocyte lysates in the presence of antisense oligodeoxynucleotides (15-20-mers) showed that oligonucleotides having complementarity within the 5' noncoding region of the mRNAs blocked translation, oligonucleotides having complementarity within 20 nucleotides upstream from the initiator codon blocked translation only partially, and oligonucleotides complementary to the coding region of mRNA had no effect on translation. The results suggest the possibility that the 80 S initiation complex may form about 20 bases upstream from the initiator codon. Alternatively, the 40 S preinitiation complex may recognize an initiator codon at least 20 nucleotides upstream from the codon, activating a helix-destabilizing process.</div>
</front>
</TEI>
</record>

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Antisense oligodeoxynucleotides provide insight into mechanism of translation initiation of two Sendai virus mRNAs.

Antisense oligodeoxynucleotides provide insight into mechanism of translation initiation of two Sendai virus mRNAs.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki