Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.
Identifieur interne : 000752 ( Ncbi/Curation ); précédent : 000751; suivant : 000753Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.
Auteurs : K. Augustyns [Belgique] ; A. Van Aerschot ; A. Van Schepdael ; C. Urbanke ; P. HerdewijnSource :
- Nucleic acids research [ 0305-1048 ] ; 1991.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Adénine.
- métabolisme : Oligodésoxyribonucléotides, Polymères.
- synthèse chimique : Polymères.
- Adénine, Composition en bases nucléiques, Oligodésoxyribonucléotides, Stabilité enzymatique, Structure moléculaire, Température.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Adenine.
- chemical , chemical synthesis : Polymers.
- chemical , chemistry : Adenine, Oligodeoxyribonucleotides.
- chemical , metabolism : Oligodeoxyribonucleotides, Polymers.
- Base Composition, Enzyme Stability, Molecular Structure, Temperature.
Abstract
(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.
DOI: 10.1093/nar/19.10.2587
PubMed: 2041735
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pubmed:2041735Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.</title><author><name sortKey="Augustyns, K" sort="Augustyns, K" uniqKey="Augustyns K" first="K" last="Augustyns">K. Augustyns</name><affiliation wicri:level="1"><nlm:affiliation>Rega Institute for Medical Research, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Van Aerschot, A" sort="Van Aerschot, A" uniqKey="Van Aerschot A" first="A" last="Van Aerschot">A. Van Aerschot</name></author><author><name sortKey="Van Schepdael, A" sort="Van Schepdael, A" uniqKey="Van Schepdael A" first="A" last="Van Schepdael">A. Van Schepdael</name></author><author><name sortKey="Urbanke, C" sort="Urbanke, C" uniqKey="Urbanke C" first="C" last="Urbanke">C. Urbanke</name></author><author><name sortKey="Herdewijn, P" sort="Herdewijn, P" uniqKey="Herdewijn P" first="P" last="Herdewijn">P. 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Augustyns</name><affiliation wicri:level="1"><nlm:affiliation>Rega Institute for Medical Research, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Van Aerschot, A" sort="Van Aerschot, A" uniqKey="Van Aerschot A" first="A" last="Van Aerschot">A. Van Aerschot</name></author><author><name sortKey="Van Schepdael, A" sort="Van Schepdael, A" uniqKey="Van Schepdael A" first="A" last="Van Schepdael">A. Van Schepdael</name></author><author><name sortKey="Urbanke, C" sort="Urbanke, C" uniqKey="Urbanke C" first="C" last="Urbanke">C. Urbanke</name></author><author><name sortKey="Herdewijn, P" sort="Herdewijn, P" uniqKey="Herdewijn P" first="P" last="Herdewijn">P. Herdewijn</name></author></analytic><series><title level="j">Nucleic acids research</title><idno type="ISSN">0305-1048</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenine (analogs & derivatives)</term><term>Adenine (chemistry)</term><term>Base Composition</term><term>Enzyme Stability</term><term>Molecular Structure</term><term>Oligodeoxyribonucleotides (chemistry)</term><term>Oligodeoxyribonucleotides (metabolism)</term><term>Polymers (chemical synthesis)</term><term>Polymers (metabolism)</term><term>Temperature</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénine ()</term><term>Adénine (analogues et dérivés)</term><term>Composition en bases nucléiques</term><term>Oligodésoxyribonucléotides ()</term><term>Oligodésoxyribonucléotides (métabolisme)</term><term>Polymères (métabolisme)</term><term>Polymères (synthèse chimique)</term><term>Stabilité enzymatique</term><term>Structure moléculaire</term><term>Température</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Polymers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenine</term><term>Oligodeoxyribonucleotides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Oligodeoxyribonucleotides</term><term>Polymers</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénine</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Oligodésoxyribonucléotides</term><term>Polymères</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Polymères</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Composition</term><term>Enzyme Stability</term><term>Molecular Structure</term><term>Temperature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adénine</term><term>Composition en bases nucléiques</term><term>Oligodésoxyribonucléotides</term><term>Stabilité enzymatique</term><term>Structure moléculaire</term><term>Température</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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