MersV1, Ncbi, Curation, bibRecord, 000261

TNF ligands: is TALL-1 a trimer or a virus-like cluster?

Identifieur interne : 000261 ( Ncbi/Curation ); précédent : 000260; suivant : 000262

TNF ligands: is TALL-1 a trimer or a virus-like cluster?

Auteurs : Eugene A. Zhukovsky [États-Unis] ; Jie-Oh Lee ; Michael Villegas ; Cheryl Chan ; Seung Chu ; Cameron Mroske

Source :

Nature [ 1476-4687 ] ; 2004.

RBID : pubmed:14749821

Descripteurs français

KwdFr :
- Artéfacts, Chromatographie sur gel, Concentration en ions d'hydrogène, Cristallographie aux rayons X, Division cellulaire (), Facteur d'activation des lymphocytes B, Facteur de nécrose tumorale alpha (), Facteur de nécrose tumorale alpha (isolement et purification), Facteur de nécrose tumorale alpha (métabolisme), Facteur de nécrose tumorale alpha (pharmacologie), Lymphocytes B (), Lymphocytes B (cytologie), Protéines de fusion recombinantes (), Protéines de fusion recombinantes (isolement et purification), Protéines de fusion recombinantes (métabolisme), Protéines de fusion recombinantes (pharmacologie), Protéines membranaires (), Protéines membranaires (isolement et purification), Protéines membranaires (métabolisme), Protéines membranaires (pharmacologie), Reproductibilité des résultats, Structure quaternaire des protéines, Survie cellulaire ().
MESH :
- cytologie : Lymphocytes B.
- isolement et purification : Facteur de nécrose tumorale alpha, Protéines de fusion recombinantes, Protéines membranaires.
- métabolisme : Facteur de nécrose tumorale alpha, Protéines de fusion recombinantes, Protéines membranaires.
- pharmacologie : Facteur de nécrose tumorale alpha, Protéines de fusion recombinantes, Protéines membranaires.
- Artéfacts, Chromatographie sur gel, Concentration en ions d'hydrogène, Cristallographie aux rayons X, Division cellulaire, Facteur d'activation des lymphocytes B, Facteur de nécrose tumorale alpha, Lymphocytes B, Protéines de fusion recombinantes, Protéines membranaires, Reproductibilité des résultats, Structure quaternaire des protéines, Survie cellulaire.

English descriptors

KwdEn :
- Artifacts, B-Cell Activating Factor, B-Lymphocytes (cytology), B-Lymphocytes (drug effects), Cell Division (drug effects), Cell Survival (drug effects), Chromatography, Gel, Crystallography, X-Ray, Hydrogen-Ion Concentration, Membrane Proteins (chemistry), Membrane Proteins (isolation & purification), Membrane Proteins (metabolism), Membrane Proteins (pharmacology), Protein Structure, Quaternary, Recombinant Fusion Proteins (chemistry), Recombinant Fusion Proteins (isolation & purification), Recombinant Fusion Proteins (metabolism), Recombinant Fusion Proteins (pharmacology), Reproducibility of Results, Tumor Necrosis Factor-alpha (chemistry), Tumor Necrosis Factor-alpha (isolation & purification), Tumor Necrosis Factor-alpha (metabolism), Tumor Necrosis Factor-alpha (pharmacology).
MESH :
- chemical , chemistry : Membrane Proteins, Recombinant Fusion Proteins, Tumor Necrosis Factor-alpha.
- chemical , isolation & purification : Membrane Proteins, Recombinant Fusion Proteins, Tumor Necrosis Factor-alpha.
- chemical , metabolism : Membrane Proteins, Recombinant Fusion Proteins, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Membrane Proteins, Recombinant Fusion Proteins, Tumor Necrosis Factor-alpha.
- chemical : B-Cell Activating Factor.
- cytology : B-Lymphocytes.
- drug effects : B-Lymphocytes, Cell Division, Cell Survival.
- Artifacts, Chromatography, Gel, Crystallography, X-Ray, Hydrogen-Ion Concentration, Protein Structure, Quaternary, Reproducibility of Results.

Abstract

Native TALL-1 (B-cell activation factor, BAFF; also known as BlyS) was initially described as a homotrimer, but Liu and colleagues claim that it is a 60-subunit complex on the basis of their results from X-ray crystallography and size-exclusion chromatography. They consider TALL-1 60-mers to be the biologically active form, and the arrangement of the 60-mers resembles that of the capsid of satellite tobacco necrosis virus. Here we show that active TALL-1 is trimeric under normal physiological conditions and that formation of higher-order oligomers is an artefact of tagging the amino terminus of the protein with a histidine tag.

DOI: 10.1038/427413a
PubMed: 14749821

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pubmed:14749821

Le document en format XML

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<author><name sortKey="Zhukovsky, Eugene A" sort="Zhukovsky, Eugene A" uniqKey="Zhukovsky E" first="Eugene A" last="Zhukovsky">Eugene A. Zhukovsky</name>
<affiliation wicri:level="1"><nlm:affiliation>Xencor, Monrovia, California 91016, USA. ezhukovsky@xencor.com</nlm:affiliation>
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<author><name sortKey="Lee, Jie Oh" sort="Lee, Jie Oh" uniqKey="Lee J" first="Jie-Oh" last="Lee">Jie-Oh Lee</name>
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<author><name sortKey="Villegas, Michael" sort="Villegas, Michael" uniqKey="Villegas M" first="Michael" last="Villegas">Michael Villegas</name>
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<author><name sortKey="Chan, Cheryl" sort="Chan, Cheryl" uniqKey="Chan C" first="Cheryl" last="Chan">Cheryl Chan</name>
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<author><name sortKey="Chu, Seung" sort="Chu, Seung" uniqKey="Chu S" first="Seung" last="Chu">Seung Chu</name>
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<author><name sortKey="Mroske, Cameron" sort="Mroske, Cameron" uniqKey="Mroske C" first="Cameron" last="Mroske">Cameron Mroske</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Artifacts</term>
<term>B-Cell Activating Factor</term>
<term>B-Lymphocytes (cytology)</term>
<term>B-Lymphocytes (drug effects)</term>
<term>Cell Division (drug effects)</term>
<term>Cell Survival (drug effects)</term>
<term>Chromatography, Gel</term>
<term>Crystallography, X-Ray</term>
<term>Hydrogen-Ion Concentration</term>
<term>Membrane Proteins (chemistry)</term>
<term>Membrane Proteins (isolation & purification)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Membrane Proteins (pharmacology)</term>
<term>Protein Structure, Quaternary</term>
<term>Recombinant Fusion Proteins (chemistry)</term>
<term>Recombinant Fusion Proteins (isolation & purification)</term>
<term>Recombinant Fusion Proteins (metabolism)</term>
<term>Recombinant Fusion Proteins (pharmacology)</term>
<term>Reproducibility of Results</term>
<term>Tumor Necrosis Factor-alpha (chemistry)</term>
<term>Tumor Necrosis Factor-alpha (isolation & purification)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
<term>Tumor Necrosis Factor-alpha (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Artéfacts</term>
<term>Chromatographie sur gel</term>
<term>Concentration en ions d'hydrogène</term>
<term>Cristallographie aux rayons X</term>
<term>Division cellulaire ()</term>
<term>Facteur d'activation des lymphocytes B</term>
<term>Facteur de nécrose tumorale alpha ()</term>
<term>Facteur de nécrose tumorale alpha (isolement et purification)</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Facteur de nécrose tumorale alpha (pharmacologie)</term>
<term>Lymphocytes B ()</term>
<term>Lymphocytes B (cytologie)</term>
<term>Protéines de fusion recombinantes ()</term>
<term>Protéines de fusion recombinantes (isolement et purification)</term>
<term>Protéines de fusion recombinantes (métabolisme)</term>
<term>Protéines de fusion recombinantes (pharmacologie)</term>
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<term>Protéines membranaires (isolement et purification)</term>
<term>Protéines membranaires (métabolisme)</term>
<term>Protéines membranaires (pharmacologie)</term>
<term>Reproductibilité des résultats</term>
<term>Structure quaternaire des protéines</term>
<term>Survie cellulaire ()</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Membrane Proteins</term>
<term>Recombinant Fusion Proteins</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Membrane Proteins</term>
<term>Recombinant Fusion Proteins</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Proteins</term>
<term>Recombinant Fusion Proteins</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Membrane Proteins</term>
<term>Recombinant Fusion Proteins</term>
<term>Tumor Necrosis Factor-alpha</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>B-Cell Activating Factor</term>
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<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>B-Lymphocytes</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>B-Lymphocytes</term>
<term>Cell Division</term>
<term>Cell Survival</term>
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<term>Protéines de fusion recombinantes</term>
<term>Protéines membranaires</term>
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<term>Protéines de fusion recombinantes</term>
<term>Protéines membranaires</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines membranaires</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Artifacts</term>
<term>Chromatography, Gel</term>
<term>Crystallography, X-Ray</term>
<term>Hydrogen-Ion Concentration</term>
<term>Protein Structure, Quaternary</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Artéfacts</term>
<term>Chromatographie sur gel</term>
<term>Concentration en ions d'hydrogène</term>
<term>Cristallographie aux rayons X</term>
<term>Division cellulaire</term>
<term>Facteur d'activation des lymphocytes B</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Lymphocytes B</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines membranaires</term>
<term>Reproductibilité des résultats</term>
<term>Structure quaternaire des protéines</term>
<term>Survie cellulaire</term>
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<front><div type="abstract" xml:lang="en">Native TALL-1 (B-cell activation factor, BAFF; also known as BlyS) was initially described as a homotrimer, but Liu and colleagues claim that it is a 60-subunit complex on the basis of their results from X-ray crystallography and size-exclusion chromatography. They consider TALL-1 60-mers to be the biologically active form, and the arrangement of the 60-mers resembles that of the capsid of satellite tobacco necrosis virus. Here we show that active TALL-1 is trimeric under normal physiological conditions and that formation of higher-order oligomers is an artefact of tagging the amino terminus of the protein with a histidine tag.</div>
</front>
</TEI>
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TNF ligands: is TALL-1 a trimer or a virus-like cluster?

TNF ligands: is TALL-1 a trimer or a virus-like cluster?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki