Reversibility of heat-induced denaturation of the recombinant human megakaryocyte growth and development factor.
Identifieur interne : 000022 ( Ncbi/Curation ); précédent : 000021; suivant : 000023Reversibility of heat-induced denaturation of the recombinant human megakaryocyte growth and development factor.
Auteurs : L O Narhi [États-Unis] ; J S Philo ; B. Sun ; B S Chang ; T. ArakawaSource :
- Pharmaceutical research [ 0724-8741 ] ; 1999.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Recombinant Proteins, Thrombopoietin.
- chemical , pharmacology : Sucrose, Urea.
- chemical : Buffers.
- Circular Dichroism, Hot Temperature, Humans, Osmolar Concentration, Protein Conformation, Protein Denaturation, Protein Folding, Surface Tension.
Abstract
The present study was performed to examine the effect of solution conditions on the reversibility of the thermal denaturation of megakaryocyte growth and development factor (rHuMGDF).
DOI: 10.1023/a:1018893115557
PubMed: 10397597
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pubmed:10397597Le document en format XML
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<author><name sortKey="Philo, J S" sort="Philo, J S" uniqKey="Philo J" first="J S" last="Philo">J S Philo</name>
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<author><name sortKey="Chang, B S" sort="Chang, B S" uniqKey="Chang B" first="B S" last="Chang">B S Chang</name>
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<author><name sortKey="Arakawa, T" sort="Arakawa, T" uniqKey="Arakawa T" first="T" last="Arakawa">T. Arakawa</name>
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<author><name sortKey="Chang, B S" sort="Chang, B S" uniqKey="Chang B" first="B S" last="Chang">B S Chang</name>
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<series><title level="j">Pharmaceutical research</title>
<idno type="ISSN">0724-8741</idno>
<imprint><date when="1999" type="published">1999</date>
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<term>Circular Dichroism</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Osmolar Concentration</term>
<term>Protein Conformation</term>
<term>Protein Denaturation</term>
<term>Protein Folding</term>
<term>Recombinant Proteins (chemistry)</term>
<term>Sucrose (pharmacology)</term>
<term>Surface Tension</term>
<term>Thrombopoietin (chemistry)</term>
<term>Urea (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Concentration osmolaire</term>
<term>Conformation des protéines</term>
<term>Dichroïsme circulaire</term>
<term>Dénaturation des protéines</term>
<term>Humains</term>
<term>Pliage des protéines</term>
<term>Protéines recombinantes ()</term>
<term>Saccharose (pharmacologie)</term>
<term>Substances tampon</term>
<term>Température élevée</term>
<term>Tension superficielle</term>
<term>Thrombopoïétine ()</term>
<term>Urée (pharmacologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Recombinant Proteins</term>
<term>Thrombopoietin</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sucrose</term>
<term>Urea</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Buffers</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Saccharose</term>
<term>Urée</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Circular Dichroism</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Osmolar Concentration</term>
<term>Protein Conformation</term>
<term>Protein Denaturation</term>
<term>Protein Folding</term>
<term>Surface Tension</term>
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<term>Conformation des protéines</term>
<term>Dichroïsme circulaire</term>
<term>Dénaturation des protéines</term>
<term>Humains</term>
<term>Pliage des protéines</term>
<term>Protéines recombinantes</term>
<term>Substances tampon</term>
<term>Température élevée</term>
<term>Tension superficielle</term>
<term>Thrombopoïétine</term>
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<front><div type="abstract" xml:lang="en">The present study was performed to examine the effect of solution conditions on the reversibility of the thermal denaturation of megakaryocyte growth and development factor (rHuMGDF).</div>
</front>
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