Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Identifieur interne : 002831 ( Ncbi/Checkpoint ); précédent : 002830; suivant : 002832Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Auteurs : Youngchang Kim [États-Unis] ; Robert Jedrzejczak [États-Unis] ; Natalia I. Maltseva [États-Unis] ; Mateusz Wilamowski [États-Unis] ; Michael Endres [États-Unis] ; Adam Godzik [États-Unis] ; Karolina Michalska [États-Unis] ; Andrzej Joachimiak [États-Unis]Source :
- Protein science : a publication of the Protein Society [ 1469-896X ] ; 2020.
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs, the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report two high-resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses. This article is protected by copyright. All rights reserved.
DOI: 10.1002/pro.3873
PubMed: 32304108
Affiliations:
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<front><div type="abstract" xml:lang="en">Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs, the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report two high-resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses. This article is protected by copyright. All rights reserved.</div>
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