Development of a SARS Coronavirus Vaccine from Recombinant Spike Protein Plus Delta Inulin Adjuvant
Identifieur interne : 001572 ( Ncbi/Checkpoint ); précédent : 001571; suivant : 001573Development of a SARS Coronavirus Vaccine from Recombinant Spike Protein Plus Delta Inulin Adjuvant
Auteurs :Source :
- Vaccine Design ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Inulin, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- chemical : Adjuvants, Immunologic.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Animals, Humans.
Abstract
Given periodic outbreaks of fatal human infections caused by coronaviruses, development of an optimal coronavirus vaccine platform capable of rapid production is an ongoing priority. This chapter describes the use of an insect cell expression system for rapid production of a recombinant vaccine against severe acute respiratory syndrome coronavirus (SARS). Detailed methods are presented for expression, purification, and release testing of SARS recombinant spike protein antigen, followed by adjuvant formulation and animal testing. The methods herein described for rapid development of a highly protective SARS vaccine are equally suited to rapid development of vaccines against other fatal human coronavirus infections, e.g., the MERS coronavirus.
Url:
DOI: 10.1007/978-1-4939-3387-7_14
PubMed: 27076136
PubMed Central: 7139448
Affiliations:
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PMC:7139448Le document en format XML
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This chapter describes the use of an insect cell expression system for rapid production of a recombinant vaccine against severe acute respiratory syndrome coronavirus (SARS). Detailed methods are presented for expression, purification, and release testing of SARS recombinant spike protein antigen, followed by adjuvant formulation and animal testing. The methods herein described for rapid development of a highly protective SARS vaccine are equally suited to rapid development of vaccines against other fatal human coronavirus infections, e.g., the MERS coronavirus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Berger, A" uniqKey="Berger A">A Berger</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Doerr, Hw" uniqKey="Doerr H">HW Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, Ma" uniqKey="Marra M">MA Marra</name></author><author><name sortKey="Jones, Sj" uniqKey="Jones S">SJ Jones</name></author><author><name sortKey="Astell, Cr" uniqKey="Astell C">CR Astell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darnell, Me" uniqKey="Darnell M">ME Darnell</name></author><author><name sortKey="Plant, Ep" uniqKey="Plant E">EP Plant</name></author><author><name sortKey="Watanabe, H" uniqKey="Watanabe H">H Watanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolles, M" uniqKey="Bolles M">M Bolles</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name></author><author><name sortKey="Long, K" uniqKey="Long K">K Long</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="See, Rh" uniqKey="See R">RH See</name></author><author><name sortKey="Zakhartchouk, An" uniqKey="Zakhartchouk A">AN Zakhartchouk</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M Petric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yasui, F" uniqKey="Yasui F">F Yasui</name></author><author><name sortKey="Kai, C" uniqKey="Kai C">C Kai</name></author><author><name sortKey="Kitabatake, M" uniqKey="Kitabatake M">M Kitabatake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author><author><name sortKey="Sbrana, E" uniqKey="Sbrana E">E Sbrana</name></author><author><name sortKey="Iwata Yoshikawa, N" uniqKey="Iwata Yoshikawa N">N Iwata-Yoshikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clay, C" uniqKey="Clay C">C Clay</name></author><author><name sortKey="Donart, N" uniqKey="Donart N">N Donart</name></author><author><name sortKey="Fomukong, N" uniqKey="Fomukong N">N Fomukong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roper, Rl" uniqKey="Roper R">RL Roper</name></author><author><name sortKey="Rehm, Ke" uniqKey="Rehm K">KE Rehm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N Vasilieva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeffers, Sa" uniqKey="Jeffers S">SA Jeffers</name></author><author><name sortKey="Tusell, Sm" uniqKey="Tusell S">SM Tusell</name></author><author><name sortKey="Gillim Ross, L" uniqKey="Gillim Ross L">L Gillim-Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name></author><author><name sortKey="Siddiqui, P" uniqKey="Siddiqui P">P Siddiqui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author><author><name sortKey="Du, J" uniqKey="Du J">J Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name></author><author><name sortKey="Post, P" uniqKey="Post P">P Post</name></author><author><name sortKey="Chubet, R" uniqKey="Chubet R">R Chubet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Openshaw, Peter J M" uniqKey="Openshaw P">Peter J.M. 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