Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques
Identifieur interne : 000B45 ( Ncbi/Checkpoint ); précédent : 000B44; suivant : 000B46Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques
Auteurs : Darryl Falzarano ; Emmie De Wit ; Angela L. Rasmussen ; Friederike Feldmann ; Atsushi Okumura ; Dana P. Scott ; Doug Brining ; Trenton Bushmaker ; Cynthia Martellaro ; Laura Baseler ; Arndt G. Benecke [France] ; Michael G. Katze ; Vincent J. Munster ; Heinz FeldmannSource :
- Nature Medicine [ 1078-8956 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (usage thérapeutique), Coronavirus (physiologie), Infections à coronavirus (traitement médicamenteux), Interféron alpha (usage thérapeutique), Macaca mulatta, Protéines recombinantes (usage thérapeutique), Ribavirine (usage thérapeutique), Réaction de polymérisation en chaine en temps réel, Réplication virale.
- MESH :
- physiologie : Coronavirus.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux, Interféron alpha, Protéines recombinantes, Ribavirine.
- Animaux, Macaca mulatta, Réaction de polymérisation en chaine en temps réel, Réplication virale.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (therapeutic use), Coronavirus (physiology), Coronavirus Infections (drug therapy), Interferon alpha-2, Interferon-alpha (therapeutic use), Macaca mulatta, Real-Time Polymerase Chain Reaction, Recombinant Proteins (therapeutic use), Ribavirin (therapeutic use), Virus Replication.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Interferon-alpha, Recombinant Proteins, Ribavirin.
- drug therapy : Coronavirus Infections.
- physiology : Coronavirus.
- Animals, Interferon alpha-2, Macaca mulatta, Real-Time Polymerase Chain Reaction, Virus Replication.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) has killed ∼50% of individuals known to be infected, making understanding its mechanisms of transmission and pathogenesis and identifying candidate treatments a high priority. Heinz Feldmann, Vincent J. Munster and Michael G. Katze and their colleagues now report that treating MERS-CoV-infected rhesus macaques with interferon-α2b and ribavirin reduced virus replication and infection severity, suggesting the potential use of this combination for the clinical treatment of infected humans.
The online version of this article (doi:10.1038/nm.3362) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nm.3362
PubMed: 24013700
PubMed Central: 4093902
Affiliations:
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PMC:4093902Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques</title>
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Seattle, Washington USA</nlm:aff>
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Seattle, Washington USA</nlm:aff>
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<author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name>
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Hamilton, Montana USA</nlm:aff>
<wicri:noCountry code="subfield">Montana USA</wicri:noCountry>
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Hamilton, Montana USA</nlm:aff>
<wicri:noCountry code="subfield">Montana USA</wicri:noCountry>
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<institution>Department of Medical Microbiology,</institution>
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Winnipeg, Manitoba Canada</nlm:aff>
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<series><title level="j">Nature Medicine</title>
<idno type="ISSN">1078-8956</idno>
<idno type="eISSN">1546-170X</idno>
<imprint><date when="2013">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Coronavirus (physiology)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Interferon alpha-2</term>
<term>Interferon-alpha (therapeutic use)</term>
<term>Macaca mulatta</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Recombinant Proteins (therapeutic use)</term>
<term>Ribavirin (therapeutic use)</term>
<term>Virus Replication</term>
</keywords>
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<term>Antiviraux (usage thérapeutique)</term>
<term>Coronavirus (physiologie)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
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<term>Macaca mulatta</term>
<term>Protéines recombinantes (usage thérapeutique)</term>
<term>Ribavirine (usage thérapeutique)</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Réplication virale</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Interferon-alpha</term>
<term>Recombinant Proteins</term>
<term>Ribavirin</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
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<term>Interferon alpha-2</term>
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<front><div type="abstract" xml:lang="en"><p id="Par1">The Middle East respiratory syndrome coronavirus (MERS-CoV) has killed ∼50% of individuals known to be infected, making understanding its mechanisms of transmission and pathogenesis and identifying candidate treatments a high priority. Heinz Feldmann, Vincent J. Munster and Michael G. Katze and their colleagues now report that treating MERS-CoV-infected rhesus macaques with interferon-α2b and ribavirin reduced virus replication and infection severity, suggesting the potential use of this combination for the clinical treatment of infected humans.</p>
<sec><title>Supplementary information</title>
<p>The online version of this article (doi:10.1038/nm.3362) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>France</li>
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<orgName><li>Université Pierre-et-Marie-Curie</li>
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<name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name>
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