Electron transfer followed by collision-induced dissociation (NET-CID) for generating sequence information from backbone-modified oligonucleotide anions.
Identifieur interne : 000A12 ( Ncbi/Checkpoint ); précédent : 000A11; suivant : 000A13Electron transfer followed by collision-induced dissociation (NET-CID) for generating sequence information from backbone-modified oligonucleotide anions.
Auteurs : Yang Gao [États-Unis] ; Scott A. McluckeySource :
- Rapid communications in mass spectrometry : RCM [ 1097-0231 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Anions, Oligonucleotides.
- methods : Tandem Mass Spectrometry.
- Models, Molecular.
Abstract
Oligonucleotides with 2'-modifications and/or phosphorothioate (PS) backbones are prone to undergo limited backbone fragmentation upon ion trap collision-induced dissociation (CID). For better identification and characterization of chemically modified oligonucleotides, a more universal fragmentation method is desirable.
DOI: 10.1002/rcm.6428
PubMed: 23239339
Affiliations:
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pubmed:23239339Le document en format XML
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