Sequence-specific synthesis of macromolecules using DNA-templated chemistry.
Identifieur interne : 000955 ( Ncbi/Checkpoint ); précédent : 000954; suivant : 000956Sequence-specific synthesis of macromolecules using DNA-templated chemistry.
Auteurs : Phillip J. Milnes [Royaume-Uni] ; Mireya L. Mckee ; Jonathan Bath ; Lijiang Song ; Eugen Stulz ; Andrew J. Turberfield ; Rachel K. O'ReillySource :
- Chemical communications (Cambridge, England) [ 1364-548X ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- synthèse chimique : ADN, Structures macromoléculaires.
- ADN, Structures macromoléculaires, Séquence nucléotidique, Techniques de chimie synthétique.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : DNA, Macromolecular Substances.
- chemical , chemistry : DNA, Macromolecular Substances.
- methods : Chemistry Techniques, Synthetic.
- Base Sequence.
Abstract
Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.
DOI: 10.1039/c2cc31975f
PubMed: 22549725
Affiliations:
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pubmed:22549725Le document en format XML
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Mckee</name></author><author><name sortKey="Bath, Jonathan" sort="Bath, Jonathan" uniqKey="Bath J" first="Jonathan" last="Bath">Jonathan Bath</name></author><author><name sortKey="Song, Lijiang" sort="Song, Lijiang" uniqKey="Song L" first="Lijiang" last="Song">Lijiang Song</name></author><author><name sortKey="Stulz, Eugen" sort="Stulz, Eugen" uniqKey="Stulz E" first="Eugen" last="Stulz">Eugen Stulz</name></author><author><name sortKey="Turberfield, Andrew J" sort="Turberfield, Andrew J" uniqKey="Turberfield A" first="Andrew J" last="Turberfield">Andrew J. Turberfield</name></author><author><name sortKey="O Reilly, Rachel K" sort="O Reilly, Rachel K" uniqKey="O Reilly R" first="Rachel K" last="O'Reilly">Rachel K. 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Milnes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Chemistry, University of Warwick, Coventry, CV4 7AL</wicri:regionArea><wicri:noRegion>CV4 7AL</wicri:noRegion></affiliation></author><author><name sortKey="Mckee, Mireya L" sort="Mckee, Mireya L" uniqKey="Mckee M" first="Mireya L" last="Mckee">Mireya L. Mckee</name></author><author><name sortKey="Bath, Jonathan" sort="Bath, Jonathan" uniqKey="Bath J" first="Jonathan" last="Bath">Jonathan Bath</name></author><author><name sortKey="Song, Lijiang" sort="Song, Lijiang" uniqKey="Song L" first="Lijiang" last="Song">Lijiang Song</name></author><author><name sortKey="Stulz, Eugen" sort="Stulz, Eugen" uniqKey="Stulz E" first="Eugen" last="Stulz">Eugen Stulz</name></author><author><name sortKey="Turberfield, Andrew J" sort="Turberfield, Andrew J" uniqKey="Turberfield A" first="Andrew J" last="Turberfield">Andrew J. Turberfield</name></author><author><name sortKey="O Reilly, Rachel K" sort="O Reilly, Rachel K" uniqKey="O Reilly R" first="Rachel K" last="O'Reilly">Rachel K. O'Reilly</name></author></analytic><series><title level="j">Chemical communications (Cambridge, England)</title><idno type="eISSN">1364-548X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term><term>Chemistry Techniques, Synthetic (methods)</term><term>DNA (chemical synthesis)</term><term>DNA (chemistry)</term><term>Macromolecular Substances (chemical synthesis)</term><term>Macromolecular Substances (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN ()</term><term>ADN (synthèse chimique)</term><term>Structures macromoléculaires ()</term><term>Structures macromoléculaires (synthèse chimique)</term><term>Séquence nucléotidique</term><term>Techniques de chimie synthétique ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>DNA</term><term>Macromolecular Substances</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term><term>Macromolecular Substances</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chemistry Techniques, Synthetic</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>ADN</term><term>Structures macromoléculaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN</term><term>Structures macromoléculaires</term><term>Séquence nucléotidique</term><term>Techniques de chimie synthétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Bath, Jonathan" sort="Bath, Jonathan" uniqKey="Bath J" first="Jonathan" last="Bath">Jonathan Bath</name><name sortKey="Mckee, Mireya L" sort="Mckee, Mireya L" uniqKey="Mckee M" first="Mireya L" last="Mckee">Mireya L. Mckee</name><name sortKey="O Reilly, Rachel K" sort="O Reilly, Rachel K" uniqKey="O Reilly R" first="Rachel K" last="O'Reilly">Rachel K. O'Reilly</name><name sortKey="Song, Lijiang" sort="Song, Lijiang" uniqKey="Song L" first="Lijiang" last="Song">Lijiang Song</name><name sortKey="Stulz, Eugen" sort="Stulz, Eugen" uniqKey="Stulz E" first="Eugen" last="Stulz">Eugen Stulz</name><name sortKey="Turberfield, Andrew J" sort="Turberfield, Andrew J" uniqKey="Turberfield A" first="Andrew J" last="Turberfield">Andrew J. Turberfield</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Milnes, Phillip J" sort="Milnes, Phillip J" uniqKey="Milnes P" first="Phillip J" last="Milnes">Phillip J. Milnes</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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