Antitumor effects of cationic synthetic peptides derived from Lys49 phospholipase A2 homologues of snake venoms.
Identifieur interne : 000491 ( Ncbi/Checkpoint ); précédent : 000490; suivant : 000492Antitumor effects of cationic synthetic peptides derived from Lys49 phospholipase A2 homologues of snake venoms.
Auteurs : Cindy Araya [Costa Rica] ; Bruno LomonteSource :
- Cell biology international [ 1065-6995 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Antinéoplasiques (pharmacologie), Cellules cancéreuses en culture, Fragments peptidiques (), Fragments peptidiques (pharmacologie), Fragments peptidiques (synthèse chimique), Group II Phospholipases A2, Injections péritoneales, Membranes (), Mort cellulaire (), Phospholipases A (), Phospholipases A2, Protéines de reptiles, Souris, Souris de lignée BALB C, Séquence d'acides aminés, Tumeurs expérimentales (anatomopathologie), Tumeurs expérimentales (métabolisme), Tumeurs expérimentales (traitement médicamenteux), Tumeurs expérimentales de la mamelle (traitement médicamenteux), Venins de crotalidé ().
- MESH :
- anatomopathologie : Tumeurs expérimentales.
- métabolisme : Tumeurs expérimentales.
- pharmacologie : Antinéoplasiques, Fragments peptidiques.
- synthèse chimique : Fragments peptidiques.
- traitement médicamenteux : Tumeurs expérimentales, Tumeurs expérimentales de la mamelle.
- Animaux, Cellules cancéreuses en culture, Fragments peptidiques, Group II Phospholipases A2, Injections péritoneales, Membranes, Mort cellulaire, Phospholipases A, Phospholipases A2, Protéines de reptiles, Souris, Souris de lignée BALB C, Séquence d'acides aminés, Venins de crotalidé.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antineoplastic Agents (pharmacology), Cell Death (drug effects), Crotalid Venoms (chemistry), Group II Phospholipases A2, Injections, Intraperitoneal, Mammary Neoplasms, Experimental (drug therapy), Membranes (drug effects), Mice, Mice, Inbred BALB C, Neoplasms, Experimental (drug therapy), Neoplasms, Experimental (metabolism), Neoplasms, Experimental (pathology), Peptide Fragments (chemical synthesis), Peptide Fragments (chemistry), Peptide Fragments (pharmacology), Phospholipases A (chemistry), Phospholipases A2, Reptilian Proteins, Tumor Cells, Cultured.
- MESH :
- chemical , chemical synthesis : Peptide Fragments.
- chemical , chemistry : Crotalid Venoms, Peptide Fragments, Phospholipases A.
- chemical , pharmacology : Antineoplastic Agents, Peptide Fragments.
- drug effects : Cell Death, Membranes.
- drug therapy : Mammary Neoplasms, Experimental, Neoplasms, Experimental.
- metabolism : Neoplasms, Experimental.
- pathology : Neoplasms, Experimental.
- Amino Acid Sequence, Animals, Group II Phospholipases A2, Injections, Intraperitoneal, Mice, Mice, Inbred BALB C, Phospholipases A2, Reptilian Proteins, Tumor Cells, Cultured.
Abstract
The effects of two cationic synthetic peptides, derived from the C-terminal region of Lys49 phospholipase A2 homologues from snake venoms, upon various murine tumor cell lines (B16 melanoma, EMT6 mammary carcinoma, S-180 sarcoma, P3X myeloma, tEnd endothelial cells) were evaluated. The peptides are 13-mers derived from Agkistrodon piscivorus piscivorus Lys49 PLA2 (p-AppK: KKYKAYFKLKCKK) and Bothrops asper Lys49 myotoxin II (pEM-2[D]: KKWRWWLKALAKK), respectively, in the latter case with slight modifications and with all-D amino acids. All tumor cells tested were susceptible to the lytic action of the peptides. The susceptibility of tumor cell lines was not higher than that of C2C12 skeletal muscle myoblasts, utilized as a non-transformed cell line control. However, in a murine model of subcutaneous solid tumor growth of EMT6 mammary carcinoma, the intraperitoneal administration of pEM-2[D] caused a tumor mass reduction of 36% (p<0.05), which was of similar magnitude to that achieved by the administration of paclitaxel, an antitumor drug in clinical use. Thus, the C-terminal peptides of Lys49 phospholipase A2 homologues present antitumor effects that might be of interest in developing therapeutic strategies against cancer.
DOI: 10.1016/j.cellbi.2006.11.007
PubMed: 17178238
Affiliations:
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pubmed:17178238Le document en format XML
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<term>Cell Death (drug effects)</term>
<term>Crotalid Venoms (chemistry)</term>
<term>Group II Phospholipases A2</term>
<term>Injections, Intraperitoneal</term>
<term>Mammary Neoplasms, Experimental (drug therapy)</term>
<term>Membranes (drug effects)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
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<term>Neoplasms, Experimental (metabolism)</term>
<term>Neoplasms, Experimental (pathology)</term>
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<term>Peptide Fragments (chemistry)</term>
<term>Peptide Fragments (pharmacology)</term>
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<term>Tumor Cells, Cultured</term>
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<term>Antinéoplasiques (pharmacologie)</term>
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<term>Fragments peptidiques (pharmacologie)</term>
<term>Fragments peptidiques (synthèse chimique)</term>
<term>Group II Phospholipases A2</term>
<term>Injections péritoneales</term>
<term>Membranes ()</term>
<term>Mort cellulaire ()</term>
<term>Phospholipases A ()</term>
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<term>Protéines de reptiles</term>
<term>Souris</term>
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<term>Séquence d'acides aminés</term>
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<term>Tumeurs expérimentales (métabolisme)</term>
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<term>Tumeurs expérimentales de la mamelle (traitement médicamenteux)</term>
<term>Venins de crotalidé ()</term>
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<term>Phospholipases A</term>
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<term>Injections, Intraperitoneal</term>
<term>Mice</term>
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<front><div type="abstract" xml:lang="en">The effects of two cationic synthetic peptides, derived from the C-terminal region of Lys49 phospholipase A2 homologues from snake venoms, upon various murine tumor cell lines (B16 melanoma, EMT6 mammary carcinoma, S-180 sarcoma, P3X myeloma, tEnd endothelial cells) were evaluated. The peptides are 13-mers derived from Agkistrodon piscivorus piscivorus Lys49 PLA2 (p-AppK: KKYKAYFKLKCKK) and Bothrops asper Lys49 myotoxin II (pEM-2[D]: KKWRWWLKALAKK), respectively, in the latter case with slight modifications and with all-D amino acids. All tumor cells tested were susceptible to the lytic action of the peptides. The susceptibility of tumor cell lines was not higher than that of C2C12 skeletal muscle myoblasts, utilized as a non-transformed cell line control. However, in a murine model of subcutaneous solid tumor growth of EMT6 mammary carcinoma, the intraperitoneal administration of pEM-2[D] caused a tumor mass reduction of 36% (p<0.05), which was of similar magnitude to that achieved by the administration of paclitaxel, an antitumor drug in clinical use. Thus, the C-terminal peptides of Lys49 phospholipase A2 homologues present antitumor effects that might be of interest in developing therapeutic strategies against cancer.</div>
</front>
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