SCS: signal, context, and structure features for genome-wide human promoter recognition.
Identifieur interne : 005461 ( Main/Merge ); précédent : 005460; suivant : 005462SCS: signal, context, and structure features for genome-wide human promoter recognition.
Auteurs : Jia Zeng [République populaire de Chine] ; Xiao-Yu Zhao ; Xiao-Qin Cao ; Hong YanSource :
- IEEE/ACM transactions on computational biology and bioinformatics [ 1557-9964 ]
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- genetics : CpG Islands, Promoter Regions, Genetic.
- methods : Genomics, Sequence Analysis, DNA.
- Algorithms, Gene Expression Regulation, Genome, Human, Humans, Societies, Scientific.
Abstract
This paper integrates the signal, context, and structure features for genome-wide human promoter recognition, which is important in improving genome annotation and analyzing transcriptional regulation without experimental supports of ESTs, cDNAs, or mRNAs. First, CpG islands are salient biological signals associated with approximately 50 percent of mammalian promoters. Second, the genomic context of promoters may have biological significance, which is based on n-mers (sequences of n bases long) and their statistics estimated from training samples. Third, sequence-dependent DNA flexibility originates from DNA 3D structures and plays an important role in guiding transcription factors to the target site in promoters. Employing decision trees, we combine above signal, context, and structure features to build a hierarchical promoter recognition system called SCS. Experimental results on controlled data sets and the entire human genome demonstrate that SCS is significantly superior in terms of sensitivity and specificity as compared to other state-of-the-art methods. The SCS promoter recognition system is available online as supplemental materials for academic use and can be found on the Computer Society Digital Library at http://doi.ieeecomputersociety.org/10.1109/TCBB.2008.95.
DOI: 10.1109/TCBB.2008.95
PubMed: 20671324
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pubmed:20671324Le document en format XML
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<term>Genomics (methods)</term>
<term>Humans</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>Sequence Analysis, DNA (methods)</term>
<term>Societies, Scientific</term>
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<term>Analyse de séquence d'ADN ()</term>
<term>Génome humain</term>
<term>Génomique ()</term>
<term>Humains</term>
<term>Ilots CpG (génétique)</term>
<term>Régions promotrices (génétique) (génétique)</term>
<term>Régulation de l'expression des gènes</term>
<term>Sociétés savantes</term>
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<term>Régions promotrices (génétique)</term>
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<term>Génomique</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en">This paper integrates the signal, context, and structure features for genome-wide human promoter recognition, which is important in improving genome annotation and analyzing transcriptional regulation without experimental supports of ESTs, cDNAs, or mRNAs. First, CpG islands are salient biological signals associated with approximately 50 percent of mammalian promoters. Second, the genomic context of promoters may have biological significance, which is based on n-mers (sequences of n bases long) and their statistics estimated from training samples. Third, sequence-dependent DNA flexibility originates from DNA 3D structures and plays an important role in guiding transcription factors to the target site in promoters. Employing decision trees, we combine above signal, context, and structure features to build a hierarchical promoter recognition system called SCS. Experimental results on controlled data sets and the entire human genome demonstrate that SCS is significantly superior in terms of sensitivity and specificity as compared to other state-of-the-art methods. The SCS promoter recognition system is available online as supplemental materials for academic use and can be found on the Computer Society Digital Library at http://doi.ieeecomputersociety.org/10.1109/TCBB.2008.95.</div>
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