MersV1, Main, Merge, bibRecord, 003D98

Nonionic Triblock Copolymers Facilitate Delivery of Exogenous Proteins into the MHC Class I and Class II Processing Pathways

Identifieur interne : 003D98 ( Main/Merge ); précédent : 003D97; suivant : 003D99

Nonionic Triblock Copolymers Facilitate Delivery of Exogenous Proteins into the MHC Class I and Class II Processing Pathways

Auteurs : Yong Ke ; Chris L. Mcgraw ; Robert L. Hunter ; Judith A. Kapp

Source :

Cellular Immunology [ 0008-8749 ] ; 1997.

RBID : ISTEX:DA34097768B921BE5DF8E3B62EDDAEE2A624C2AC

English descriptors

Teeft :
- Additional incubation, Adjuvant, Adjuvant activity, Cell hybridoma, Cell responses, Cial, Copolymer, Cytotoxicity, Dos, Endogenous, Enhancement, Exogenous, Exogenous antigens, High concentrations, Hybridoma, Immunol, Llnl, Macrophage, Nonionic, Nonionic triblock copolymers, Nonphagocytic, Nonphagocytic cells, Other copolymers, Pathway, Peptide, Peptide binding, Spleen cells, Supernatant, Target cells, Triblock, Various concentrations.

Abstract

Abstract: Nonionic triblock copolymers are relatively nontoxic adjuvants that induce high-titer, long-lasting antibody responses. We have previously shown that these adjuvants also induce cell-mediated immunity including lymphokine production by CD4+T cells and cytolytic responses by CD8+T cells. These copolymers are thought to modulate hydrophobic adhesive interactions between antigens (Ag) and lymphoid cells. We sought to test the hypothesis that copolymers facilitate uptake of exogenous Ag by antigen-presenting cells (APC) using anin vitromodel system. Our data show that nonionic triblock copolymers enhanced presentation of soluble ovalbumin (OVA) to the major histocompatibility complex (MHC) class II-restricted CD4+T cells and MHC class I-restricted CD8+T cells, respectively. Presentation of OVA via the class I pathway was enhanced by copolymers in both phagocytic and nonphagocytic APC. However, copolymers did not enhance binding of peptides to the MHC molecules on APC, presentation of endogenously synthesized Ag, or presentation of exogenous Ag delivered by electroporation. These results provide additional evidence that these nonionic triblock copolymers can serve as powerful adjuvants for augmenting both humoral and cell-mediated immunity to protein Ag.

Url:

https://api.istex.fr/ark:/67375/6H6-20QRX2GP-5/fulltext.pdf

DOI: 10.1006/cimm.1997.1084

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001D77
to stream Istex, to step Curation: 001D77
to stream Istex, to step Checkpoint: 001519

Links to Exploration step

ISTEX:DA34097768B921BE5DF8E3B62EDDAEE2A624C2AC

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nonionic Triblock Copolymers Facilitate Delivery of Exogenous Proteins into the MHC Class I and Class II Processing Pathways</title>
<author><name sortKey="Ke, Yong" sort="Ke, Yong" uniqKey="Ke Y" first="Yong" last="Ke">Yong Ke</name>
</author>
<author><name sortKey="Mcgraw, Chris L" sort="Mcgraw, Chris L" uniqKey="Mcgraw C" first="Chris L." last="Mcgraw">Chris L. Mcgraw</name>
</author>
<author><name sortKey="Hunter, Robert L" sort="Hunter, Robert L" uniqKey="Hunter R" first="Robert L." last="Hunter">Robert L. Hunter</name>
</author>
<author><name sortKey="Kapp, Judith A" sort="Kapp, Judith A" uniqKey="Kapp J" first="Judith A." last="Kapp">Judith A. Kapp</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:DA34097768B921BE5DF8E3B62EDDAEE2A624C2AC</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1006/cimm.1997.1084</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-20QRX2GP-5/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001D77</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D77</idno>
<idno type="wicri:Area/Istex/Curation">001D77</idno>
<idno type="wicri:Area/Istex/Checkpoint">001519</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001519</idno>
<idno type="wicri:doubleKey">0008-8749:1997:Ke Y:nonionic:triblock:copolymers</idno>
<idno type="wicri:Area/Main/Merge">003D98</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Nonionic Triblock Copolymers Facilitate Delivery of Exogenous Proteins into the MHC Class I and Class II Processing Pathways</title>
<author><name sortKey="Ke, Yong" sort="Ke, Yong" uniqKey="Ke Y" first="Yong" last="Ke">Yong Ke</name>
<affiliation><wicri:noCountry code="subField">30322</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mcgraw, Chris L" sort="Mcgraw, Chris L" uniqKey="Mcgraw C" first="Chris L." last="Mcgraw">Chris L. Mcgraw</name>
<affiliation><wicri:noCountry code="subField">30322</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hunter, Robert L" sort="Hunter, Robert L" uniqKey="Hunter R" first="Robert L." last="Hunter">Robert L. Hunter</name>
<affiliation><wicri:noCountry code="subField">30322</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kapp, Judith A" sort="Kapp, Judith A" uniqKey="Kapp J" first="Judith A." last="Kapp">Judith A. Kapp</name>
<affiliation><wicri:noCountry code="subField">30322</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Cellular Immunology</title>
<title level="j" type="abbrev">YCIMM</title>
<idno type="ISSN">0008-8749</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1997">1997</date>
<biblScope unit="volume">176</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="113">113</biblScope>
<biblScope unit="page" to="121">121</biblScope>
</imprint>
<idno type="ISSN">0008-8749</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0008-8749</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Additional incubation</term>
<term>Adjuvant</term>
<term>Adjuvant activity</term>
<term>Cell hybridoma</term>
<term>Cell responses</term>
<term>Cial</term>
<term>Copolymer</term>
<term>Cytotoxicity</term>
<term>Dos</term>
<term>Endogenous</term>
<term>Enhancement</term>
<term>Exogenous</term>
<term>Exogenous antigens</term>
<term>High concentrations</term>
<term>Hybridoma</term>
<term>Immunol</term>
<term>Llnl</term>
<term>Macrophage</term>
<term>Nonionic</term>
<term>Nonionic triblock copolymers</term>
<term>Nonphagocytic</term>
<term>Nonphagocytic cells</term>
<term>Other copolymers</term>
<term>Pathway</term>
<term>Peptide</term>
<term>Peptide binding</term>
<term>Spleen cells</term>
<term>Supernatant</term>
<term>Target cells</term>
<term>Triblock</term>
<term>Various concentrations</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Nonionic triblock copolymers are relatively nontoxic adjuvants that induce high-titer, long-lasting antibody responses. We have previously shown that these adjuvants also induce cell-mediated immunity including lymphokine production by CD4+T cells and cytolytic responses by CD8+T cells. These copolymers are thought to modulate hydrophobic adhesive interactions between antigens (Ag) and lymphoid cells. We sought to test the hypothesis that copolymers facilitate uptake of exogenous Ag by antigen-presenting cells (APC) using anin vitromodel system. Our data show that nonionic triblock copolymers enhanced presentation of soluble ovalbumin (OVA) to the major histocompatibility complex (MHC) class II-restricted CD4+T cells and MHC class I-restricted CD8+T cells, respectively. Presentation of OVA via the class I pathway was enhanced by copolymers in both phagocytic and nonphagocytic APC. However, copolymers did not enhance binding of peptides to the MHC molecules on APC, presentation of endogenously synthesized Ag, or presentation of exogenous Ag delivered by electroporation. These results provide additional evidence that these nonionic triblock copolymers can serve as powerful adjuvants for augmenting both humoral and cell-mediated immunity to protein Ag.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003D98 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003D98 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:DA34097768B921BE5DF8E3B62EDDAEE2A624C2AC
   |texte=   Nonionic Triblock Copolymers Facilitate Delivery of Exogenous Proteins into the MHC Class I and Class II Processing Pathways
}}

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Nonionic Triblock Copolymers Facilitate Delivery of Exogenous Proteins into the MHC Class I and Class II Processing Pathways

Nonionic Triblock Copolymers Facilitate Delivery of Exogenous Proteins into the MHC Class I and Class II Processing Pathways

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri