DSTHO: database of siRNAs targeted at human oncogenes: a statistical analysis.
Identifieur interne : 002D68 ( Main/Merge ); précédent : 002D67; suivant : 002D69DSTHO: database of siRNAs targeted at human oncogenes: a statistical analysis.
Auteurs : Ranjit Dash [Inde] ; S S Moharana ; A Srinivas Reddy ; G Madhavi Sastry ; G Narahari SastrySource :
- International journal of biological macromolecules [ 0141-8130 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- génétique : ADN tumoral, Petit ARN interférent, Tumeurs.
- usage thérapeutique : Petit ARN interférent.
- Bases de données d'acides nucléiques, Biométrie, Composition en bases nucléiques, Humains, Logiciel, Oncogènes, Séquence nucléotidique, Tumeurs.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Neoplasm, RNA, Small Interfering.
- genetics : Neoplasms.
- chemical , therapeutic use : RNA, Small Interfering.
- therapy : Neoplasms.
- Base Composition, Base Sequence, Biometry, Databases, Nucleic Acid, Humans, Oncogenes, Software.
Abstract
Existing treatments of human cancer, which is characterized by abnormal proliferation of cells often lead to fatal outcomes. Sequence selective silencing of oncogene expression using siRNA technology is emerging as a potential solution for cancer treatment. The exclusive selectivity and easy application to virtually any therapeutic target including intracellular factors and transcription factors renders siRNA oligonucleotide applications very promising. However, synthesis of siRNA having sufficient knockdown efficiency is laborious and cost intensive. The database is designed in order to aid the synthesis of siRNAs, which target human oncogenes (OsiRNAs). It provides OsiRNAs of known efficacy from previous experiments with links to published literature and theoretically pre-generated putative target sequences. In addition, links to available theoretical tools, databases and literature corresponding to siRNAs in general are also provided. The links to literature provide information about role of siRNA in therapeutics, chemical properties and transfection methods. Statistical analysis of mono-, di- and tri- mers located in OsiRNAs of known efficacies is performed to identify positional preferences and screen specific motifs. This analysis aids the design and synthesis of effective siRNAs, which particularly target human oncogenes. The database can be accessed at .
DOI: 10.1016/j.ijbiomac.2005.12.024
PubMed: 16448692
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002280
- to stream PubMed, to step Curation: 002280
- to stream PubMed, to step Checkpoint: 002143
- to stream Ncbi, to step Merge: 000402
- to stream Ncbi, to step Curation: 000402
- to stream Ncbi, to step Checkpoint: 000402
Links to Exploration step
pubmed:16448692Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DSTHO: database of siRNAs targeted at human oncogenes: a statistical analysis.</title><author><name sortKey="Dash, Ranjit" sort="Dash, Ranjit" uniqKey="Dash R" first="Ranjit" last="Dash">Ranjit Dash</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Modeling Group, Organic Chemical Sciences, Indian Institute of Chemical Technology, Hyderabad 500007, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Molecular Modeling Group, Organic Chemical Sciences, Indian Institute of Chemical Technology, Hyderabad 500007</wicri:regionArea><wicri:noRegion>Hyderabad 500007</wicri:noRegion></affiliation></author><author><name sortKey="Moharana, S S" sort="Moharana, S S" uniqKey="Moharana S" first="S S" last="Moharana">S S Moharana</name></author><author><name sortKey="Reddy, A Srinivas" sort="Reddy, A Srinivas" uniqKey="Reddy A" first="A Srinivas" last="Reddy">A Srinivas Reddy</name></author><author><name sortKey="Sastry, G Madhavi" sort="Sastry, G Madhavi" uniqKey="Sastry G" first="G Madhavi" last="Sastry">G Madhavi Sastry</name></author><author><name sortKey="Sastry, G Narahari" sort="Sastry, G Narahari" uniqKey="Sastry G" first="G Narahari" last="Sastry">G Narahari Sastry</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16448692</idno><idno type="pmid">16448692</idno><idno type="doi">10.1016/j.ijbiomac.2005.12.024</idno><idno type="wicri:Area/PubMed/Corpus">002280</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002280</idno><idno type="wicri:Area/PubMed/Curation">002280</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002280</idno><idno type="wicri:Area/PubMed/Checkpoint">002143</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002143</idno><idno type="wicri:Area/Ncbi/Merge">000402</idno><idno type="wicri:Area/Ncbi/Curation">000402</idno><idno type="wicri:Area/Ncbi/Checkpoint">000402</idno><idno type="wicri:doubleKey">0141-8130:2006:Dash R:dstho:database:of</idno><idno type="wicri:Area/Main/Merge">002D68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">DSTHO: database of siRNAs targeted at human oncogenes: a statistical analysis.</title><author><name sortKey="Dash, Ranjit" sort="Dash, Ranjit" uniqKey="Dash R" first="Ranjit" last="Dash">Ranjit Dash</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Modeling Group, Organic Chemical Sciences, Indian Institute of Chemical Technology, Hyderabad 500007, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Molecular Modeling Group, Organic Chemical Sciences, Indian Institute of Chemical Technology, Hyderabad 500007</wicri:regionArea><wicri:noRegion>Hyderabad 500007</wicri:noRegion></affiliation></author><author><name sortKey="Moharana, S S" sort="Moharana, S S" uniqKey="Moharana S" first="S S" last="Moharana">S S Moharana</name></author><author><name sortKey="Reddy, A Srinivas" sort="Reddy, A Srinivas" uniqKey="Reddy A" first="A Srinivas" last="Reddy">A Srinivas Reddy</name></author><author><name sortKey="Sastry, G Madhavi" sort="Sastry, G Madhavi" uniqKey="Sastry G" first="G Madhavi" last="Sastry">G Madhavi Sastry</name></author><author><name sortKey="Sastry, G Narahari" sort="Sastry, G Narahari" uniqKey="Sastry G" first="G Narahari" last="Sastry">G Narahari Sastry</name></author></analytic><series><title level="j">International journal of biological macromolecules</title><idno type="ISSN">0141-8130</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Composition</term><term>Base Sequence</term><term>Biometry</term><term>DNA, Neoplasm (genetics)</term><term>Databases, Nucleic Acid</term><term>Humans</term><term>Neoplasms (genetics)</term><term>Neoplasms (therapy)</term><term>Oncogenes</term><term>RNA, Small Interfering (genetics)</term><term>RNA, Small Interfering (therapeutic use)</term><term>Software</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN tumoral (génétique)</term><term>Bases de données d'acides nucléiques</term><term>Biométrie</term><term>Composition en bases nucléiques</term><term>Humains</term><term>Logiciel</term><term>Oncogènes</term><term>Petit ARN interférent (génétique)</term><term>Petit ARN interférent (usage thérapeutique)</term><term>Séquence nucléotidique</term><term>Tumeurs ()</term><term>Tumeurs (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Neoplasm</term><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN tumoral</term><term>Petit ARN interférent</term><term>Tumeurs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Composition</term><term>Base Sequence</term><term>Biometry</term><term>Databases, Nucleic Acid</term><term>Humans</term><term>Oncogenes</term><term>Software</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Bases de données d'acides nucléiques</term><term>Biométrie</term><term>Composition en bases nucléiques</term><term>Humains</term><term>Logiciel</term><term>Oncogènes</term><term>Séquence nucléotidique</term><term>Tumeurs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Existing treatments of human cancer, which is characterized by abnormal proliferation of cells often lead to fatal outcomes. Sequence selective silencing of oncogene expression using siRNA technology is emerging as a potential solution for cancer treatment. The exclusive selectivity and easy application to virtually any therapeutic target including intracellular factors and transcription factors renders siRNA oligonucleotide applications very promising. However, synthesis of siRNA having sufficient knockdown efficiency is laborious and cost intensive. The database is designed in order to aid the synthesis of siRNAs, which target human oncogenes (OsiRNAs). It provides OsiRNAs of known efficacy from previous experiments with links to published literature and theoretically pre-generated putative target sequences. In addition, links to available theoretical tools, databases and literature corresponding to siRNAs in general are also provided. The links to literature provide information about role of siRNA in therapeutics, chemical properties and transfection methods. Statistical analysis of mono-, di- and tri- mers located in OsiRNAs of known efficacies is performed to identify positional preferences and screen specific motifs. This analysis aids the design and synthesis of effective siRNAs, which particularly target human oncogenes. The database can be accessed at .</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D68 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002D68 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:16448692
|texte= DSTHO: database of siRNAs targeted at human oncogenes: a statistical analysis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:16448692" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |