A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome
Identifieur interne : 001D82 ( Main/Merge ); précédent : 001D81; suivant : 001D83A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome
Auteurs : Md Mahmudul Hasan [États-Unis] ; Rozina Akter [États-Unis] ; Md. Shahin Ullah [Bangladesh] ; Md. Jaynul Abedin [Bangladesh] ; G. M. Ahsan Ullah [Bangladesh] ; Md. Zakir Hossain [États-Unis]Source :
- Advances in Bioinformatics [ 1687-8027 ] ; 2014.
Abstract
The new epidemic Middle East Respiratory Syndrome (MERS) is caused by a type of human coronavirus called MERS-CoV which has global fatality rate of about 30%. We are investigating potential antiviral therapeutics against MERS-CoV by using host microRNAs (miRNAs) which may downregulate viral gene expression to quell viral replication. We computationally predicted potential 13 cellular miRNAs from 11 potential hairpin sequences of MERS-CoV genome. Our study provided an interesting hypothesis that those miRNAs, that is, hsa-miR-628-5p, hsa-miR-6804-3p, hsa-miR-4289, hsa-miR-208a-3p, hsa-miR-510-3p, hsa-miR-18a-3p, hsa-miR-329-3p, hsa-miR-548ax, hsa-miR-3934-5p, hsa-miR-4474-5p, hsa-miR-7974, hsa-miR-6865-5p, and hsa-miR-342-3p, would be antiviral therapeutics against MERS-CoV infection.
Url:
DOI: 10.1155/2014/967946
PubMed: 25610462
PubMed Central: 4283225
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<front><div type="abstract" xml:lang="en"><p>The new epidemic Middle East Respiratory Syndrome (MERS) is caused by a type of human coronavirus called MERS-CoV which has global fatality rate of about 30%. We are investigating potential antiviral therapeutics against MERS-CoV by using host microRNAs (miRNAs) which may downregulate viral gene expression to quell viral replication. We computationally predicted potential 13 cellular miRNAs from 11 potential hairpin sequences of MERS-CoV genome. Our study provided an interesting hypothesis that those miRNAs, that is, hsa-miR-628-5p, hsa-miR-6804-3p, hsa-miR-4289, hsa-miR-208a-3p, hsa-miR-510-3p, hsa-miR-18a-3p, hsa-miR-329-3p, hsa-miR-548ax, hsa-miR-3934-5p, hsa-miR-4474-5p, hsa-miR-7974, hsa-miR-6865-5p, and hsa-miR-342-3p, would be antiviral therapeutics against MERS-CoV infection.</p>
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