Serveur d'exploration MERS

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Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study

Identifieur interne : 001B00 ( Main/Merge ); précédent : 001A99; suivant : 001B01

Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study

Auteurs : Z. A. Memish ; J. A. Al-Tawfiq ; H. Q. Makhdoom ; A. A. Al-Rabeeah ; A. Assiri ; R. F. Alhakeem ; F. A. Alrabiah ; S. Al Hajjar ; A. Albarrak ; H. Flemban ; H. Balkhy ; M. Barry ; S. Alhassan ; S. Alsubaie ; A. Zumla

Source :

RBID : PMC:7128421

Descripteurs français

English descriptors

Abstract

Abstract

The Saudi Arabian Ministry of Health implemented a pro‐active surveillance programme for Middle East respiratory syndrome (MERS) coronavirus (MERSCoV). We report MERSCoV data from 5065 Kingdom of Saudi Arabia individuals who were screened for MERSCoV over a 12‐month period. From 1 October 2012 to 30 September 2013, demographic and clinical data were prospectively collected from all laboratory forms received at the Saudi Arabian Virology reference laboratory. Data were analysed by referral type, age, gender, and MERSCoV real‐time PCR test results. Five thousand and 65 individuals were screened for MERCoV: hospitalized patients with suspected MERSCoV infection (n = 2908, 57.4%), healthcare worker (HCW) contacts (n = 1695; 33.5%), and family contacts of laboratory‐confirmed MERS cases (= 462; 9.1%). Eleven per cent of persons tested were children (<17 years of age). There were 108 cases (99 adults and nine children) of MERSCoV infection detected during the 12‐month period (108/5065, 2% case detection rate). Of 108 cases, 45 were females (six children and 39 adults) and 63 were males (three children and 60 adults). Of the 99 adults with MERSCoV infection, 70 were hospitalized patients, 19 were HCW contacts, and ten were family contacts. There were no significant increases in MERSCoV detection rates over the 12‐month period: 2.6% (19/731) in July 2013, 1.7% (19/1100) in August 2013, and 1.69% (21/1238) in September 2013. Male patients had a significantly higher MERSCoV infection rate (63/2318, 2.7%) than females (45/2747, 1.6%) (p 0.013). MERSCoV rates remain at low levels, with no significant increase over time. Pro‐active surveillance for MERSCoV in newly diagnosed patients and their contacts will continue.


Url:
DOI: 10.1111/1469-0691.12562
PubMed: 24460984
PubMed Central: 7128421

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PMC:7128421

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<term>Adolescent</term>
<term>Adult</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Cross Infection (diagnosis)</term>
<term>Cross Infection (epidemiology)</term>
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<term>Health Personnel (statistics & numerical data)</term>
<term>Humans</term>
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<term>Mass Screening</term>
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<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
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<term>Saudi Arabia (epidemiology)</term>
<term>Sex Factors</term>
<term>Young Adult</term>
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<term>Adolescent</term>
<term>Adulte</term>
<term>Arabie saoudite (épidémiologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
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<term>Famille</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infection croisée (diagnostic)</term>
<term>Infection croisée (épidémiologie)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (épidémiologie)</term>
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<term>Middle East Respiratory Syndrome Coronavirus</term>
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<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
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<term>Middle East Respiratory Syndrome Coronavirus</term>
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<term>Adult</term>
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<front>
<div type="abstract" xml:lang="en">
<title>Abstract</title>
<p>The
<styled-content style="fixed-case" toggle="no">S</styled-content>
audi
<styled-content style="fixed-case" toggle="no">A</styled-content>
rabian
<styled-content style="fixed-case" toggle="no">M</styled-content>
inistry of
<styled-content style="fixed-case" toggle="no">H</styled-content>
ealth implemented a pro‐active surveillance programme for Middle East respiratory syndrome (
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
) coronavirus (
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
). We report
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
data from 5065 Kingdom of Saudi Arabia individuals who were screened for
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
over a 12‐month period. From 1
<styled-content style="fixed-case" toggle="no">O</styled-content>
ctober 2012 to 30
<styled-content style="fixed-case" toggle="no">S</styled-content>
eptember 2013, demographic and clinical data were prospectively collected from all laboratory forms received at the
<styled-content style="fixed-case" toggle="no">S</styled-content>
audi
<styled-content style="fixed-case" toggle="no">A</styled-content>
rabian
<styled-content style="fixed-case" toggle="no">V</styled-content>
irology reference laboratory. Data were analysed by referral type, age, gender, and
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
real‐time
<styled-content style="fixed-case" toggle="no">PCR</styled-content>
test results. Five thousand and 65 individuals were screened for
<styled-content style="fixed-case" toggle="no">MER</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
: hospitalized patients with suspected
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
infection (
<italic>n</italic>
 = 2908, 57.4%), healthcare worker (
<styled-content style="fixed-case" toggle="no">HCW</styled-content>
) contacts (
<italic>n</italic>
 = 1695; 33.5%), and family contacts of laboratory‐confirmed
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
cases (
<italic></italic>
=
<italic> </italic>
462; 9.1%). Eleven per cent of persons tested were children (<17 years of age). There were 108 cases (99 adults and nine children) of
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
infection detected during the 12‐month period (108/5065, 2% case detection rate). Of 108 cases, 45 were females (six children and 39 adults) and 63 were males (three children and 60 adults). Of the 99 adults with
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
infection, 70 were hospitalized patients, 19 were
<styled-content style="fixed-case" toggle="no">HCW</styled-content>
contacts, and ten were family contacts. There were no significant increases in
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
detection rates over the 12‐month period: 2.6% (19/731) in
<styled-content style="fixed-case" toggle="no">J</styled-content>
uly 2013, 1.7% (19/1100) in
<styled-content style="fixed-case" toggle="no">A</styled-content>
ugust 2013, and 1.69% (21/1238) in
<styled-content style="fixed-case" toggle="no">S</styled-content>
eptember 2013. Male patients had a significantly higher
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
infection rate (63/2318, 2.7%) than females (45/2747, 1.6%) (p 0.013).
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
rates remain at low levels, with no significant increase over time. Pro‐active surveillance for
<styled-content style="fixed-case" toggle="no">MERS</styled-content>
<styled-content style="fixed-case" toggle="no">C</styled-content>
o
<styled-content style="fixed-case" toggle="no">V</styled-content>
in newly diagnosed patients and their contacts will continue.</p>
</div>
</front>
<back>
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Pour manipuler ce document sous Unix (Dilib)

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B00 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001B00 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
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