Exploiting topic modeling to boost metagenomic reads binning
Identifieur interne : 001802 ( Main/Merge ); précédent : 001801; suivant : 001803Exploiting topic modeling to boost metagenomic reads binning
Auteurs : Ruichang Zhang [République populaire de Chine] ; Zhanzhan Cheng [République populaire de Chine] ; Jihong Guan [République populaire de Chine] ; Shuigeng Zhou [République populaire de Chine]Source :
- BMC Bioinformatics [ 1471-2105 ] ; 2015.
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Abstract
With the rapid development of high-throughput technologies, researchers can sequence the whole metagenome of a microbial community sampled directly from the environment. The assignment of these metagenomic reads into different species or taxonomical classes is a vital step for metagenomic analysis, which is referred to as
In this paper, we propose a new method
Experiments show that the new method TM-MCluster outperforms major existing methods, including AbundanceBin, MetaCluster 3.0/5.0 and MCluster. This result indicates that the exploitation of topic modeling can effectively improve the binning performance of metagenomic reads.
Url:
DOI: 10.1186/1471-2105-16-S5-S2
PubMed: 25859745
PubMed Central: 4402587
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last="Cheng">Zhanzhan Cheng</name><affiliation wicri:level="1"><nlm:aff id="I1">Shanghai Key Lab of Intelligent Information Processing, and School of Computer Science, Fudan University, 220 Handan Road, Shanghai 200433, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Key Lab of Intelligent Information Processing, and School of Computer Science, Fudan University, 220 Handan Road, Shanghai 200433</wicri:regionArea><wicri:noRegion>Shanghai 200433</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Jihong" sort="Guan, Jihong" uniqKey="Guan J" first="Jihong" last="Guan">Jihong Guan</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Computer Science and Technology, Tongji University, 4800 Cao'an Highway, Shanghai 201804, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Computer Science and Technology, Tongji University, 4800 Cao'an Highway, Shanghai 201804</wicri:regionArea><wicri:noRegion>Shanghai 201804</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Shuigeng" sort="Zhou, Shuigeng" uniqKey="Zhou S" first="Shuigeng" last="Zhou">Shuigeng Zhou</name><affiliation wicri:level="1"><nlm:aff id="I1">Shanghai Key Lab of Intelligent Information Processing, and School of Computer Science, Fudan University, 220 Handan Road, Shanghai 200433, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Key Lab of Intelligent Information Processing, and School of Computer Science, Fudan University, 220 Handan Road, Shanghai 200433</wicri:regionArea><wicri:noRegion>Shanghai 200433</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Bioinformatics</title><idno type="eISSN">1471-2105</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Cluster Analysis</term><term>DNA Barcoding, Taxonomic (methods)</term><term>Genome, Bacterial</term><term>High-Throughput Nucleotide Sequencing</term><term>Metagenome</term><term>Metagenomics (methods)</term><term>Microbiota (genetics)</term><term>Molecular Sequence Annotation (methods)</term><term>Phylogeny</term><term>Sequence Analysis, DNA (methods)</term><term>Software</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Algorithmes</term><term>Analyse de regroupements</term><term>Analyse de séquence d'ADN ()</term><term>Annotation de séquence moléculaire ()</term><term>Codage à barres de l'ADN pour la taxonomie ()</term><term>Génome bactérien</term><term>Logiciel</term><term>Microbiote (génétique)</term><term>Métagénome</term><term>Métagénomique ()</term><term>Phylogénie</term><term>Séquençage nucléotidique à haut débit</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Microbiota</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Microbiote</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>DNA Barcoding, Taxonomic</term><term>Metagenomics</term><term>Molecular Sequence Annotation</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Cluster Analysis</term><term>Genome, Bacterial</term><term>High-Throughput Nucleotide Sequencing</term><term>Metagenome</term><term>Phylogeny</term><term>Software</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Algorithmes</term><term>Analyse de regroupements</term><term>Analyse de séquence d'ADN</term><term>Annotation de séquence moléculaire</term><term>Codage à barres de l'ADN pour la taxonomie</term><term>Génome bactérien</term><term>Logiciel</term><term>Métagénome</term><term>Métagénomique</term><term>Phylogénie</term><term>Séquençage nucléotidique à haut débit</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>With the rapid development of high-throughput technologies, researchers can sequence the whole metagenome of a microbial community sampled directly from the environment. The assignment of these metagenomic reads into different species or taxonomical classes is a vital step for metagenomic analysis, which is referred to as <italic>binning </italic>of metagenomic data.</p></sec><sec><title>Results</title><p>In this paper, we propose a new method <italic>TM-MCluster </italic>for binning metagenomic reads. First, we represent each metagenomic read as a set of "k-mers" with their frequencies occurring in the read. Then, we employ a probabilistic topic model -- the Latent Dirichlet Allocation (LDA) model to the reads, which generates a number of hidden "topics" such that each read can be represented by a distribution vector of the generated topics. Finally, as in the MCluster method, we apply SKWIC -- a variant of the classical K-means algorithm with automatic feature weighting mechanism to cluster these reads represented by topic distributions.</p></sec><sec><title>Conclusions</title><p>Experiments show that the new method TM-MCluster outperforms major existing methods, including AbundanceBin, MetaCluster 3.0/5.0 and MCluster. This result indicates that the exploitation of topic modeling can effectively improve the binning performance of metagenomic reads.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Qin, J" uniqKey="Qin J">J Qin</name></author><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Raes, J" uniqKey="Raes J">J Raes</name></author><author><name sortKey="Arumugam, M" uniqKey="Arumugam M">M Arumugam</name></author><author><name sortKey="Burgdorf, Ks" uniqKey="Burgdorf K">KS Burgdorf</name></author><author><name sortKey="Manichanh, C" uniqKey="Manichanh C">C Manichanh</name></author><author><name sortKey="Nielsen, T" uniqKey="Nielsen T">T Nielsen</name></author><author><name sortKey="Pons, N" uniqKey="Pons N">N Pons</name></author><author><name sortKey="Levenez, F" uniqKey="Levenez F">F Levenez</name></author><author><name sortKey="Yamada, T" uniqKey="Yamada T">T Yamada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khachatryan, Za" uniqKey="Khachatryan Z">ZA Khachatryan</name></author><author><name sortKey="Ktsoyan, Za" uniqKey="Ktsoyan Z">ZA Ktsoyan</name></author><author><name sortKey="Manukyan, Gp" uniqKey="Manukyan G">GP Manukyan</name></author><author><name sortKey="Kelly, D" uniqKey="Kelly D">D Kelly</name></author><author><name sortKey="Ghazaryan, Ka" uniqKey="Ghazaryan K">KA Ghazaryan</name></author><author><name sortKey="Aminov, Ri" uniqKey="Aminov R">RI Aminov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mavromatis, K" uniqKey="Mavromatis K">K Mavromatis</name></author><author><name sortKey="Ivanova, N" uniqKey="Ivanova N">N Ivanova</name></author><author><name sortKey="Barry, K" uniqKey="Barry K">K Barry</name></author><author><name sortKey="Shapiro, H" uniqKey="Shapiro H">H Shapiro</name></author><author><name sortKey="Goltsman, E" uniqKey="Goltsman E">E Goltsman</name></author><author><name sortKey="Mchardy, Ac" uniqKey="Mchardy A">AC McHardy</name></author><author><name sortKey="Rigoutsos, I" uniqKey="Rigoutsos I">I Rigoutsos</name></author><author><name sortKey="Salamov, A" uniqKey="Salamov A">A Salamov</name></author><author><name sortKey="Korzeniewski, F" uniqKey="Korzeniewski F">F Korzeniewski</name></author><author><name sortKey="Land, M" uniqKey="Land M">M Land</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huson, Dh" uniqKey="Huson D">DH Huson</name></author><author><name sortKey="Richter, Dc" uniqKey="Richter D">DC Richter</name></author><author><name sortKey="Mitra, S" uniqKey="Mitra S">S Mitra</name></author><author><name sortKey="Auch, Af" uniqKey="Auch A">AF Auch</name></author><author><name sortKey="Schuster, Sc" uniqKey="Schuster S">SC Schuster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mchardy, Ac" uniqKey="Mchardy A">AC McHardy</name></author><author><name sortKey="Martin, Hg" uniqKey="Martin H">HG Martin</name></author><author><name sortKey="Tsirigos, A" uniqKey="Tsirigos A">A Tsirigos</name></author><author><name sortKey="Hugenholtz, P" uniqKey="Hugenholtz P">P Hugenholtz</name></author><author><name sortKey="Rigoutsos, I" uniqKey="Rigoutsos I">I Rigoutsos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stark, M" uniqKey="Stark M">M Stark</name></author><author><name sortKey="Berger, S" uniqKey="Berger S">S Berger</name></author><author><name sortKey="Stamatakis, A" uniqKey="Stamatakis A">A Stamatakis</name></author><author><name sortKey="Von Mering, C" uniqKey="Von Mering C">C von Mering</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diaz, Nn" uniqKey="Diaz N">NN Diaz</name></author><author><name sortKey="Krause, L" uniqKey="Krause L">L Krause</name></author><author><name sortKey="Goesmann, A" uniqKey="Goesmann A">A Goesmann</name></author><author><name sortKey="Niehaus, K" uniqKey="Niehaus K">K Niehaus</name></author><author><name sortKey="Nattkemper, Tw" uniqKey="Nattkemper T">TW Nattkemper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brady, A" uniqKey="Brady A">A Brady</name></author><author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL Salzberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Y W" uniqKey="Wu Y">Y-W Wu</name></author><author><name sortKey="Ye, Y" uniqKey="Ye Y">Y Ye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Hc" uniqKey="Leung H">HC Leung</name></author><author><name sortKey="Yiu, S M" uniqKey="Yiu S">S-M Yiu</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name></author><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y Peng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Qin, J" uniqKey="Qin J">J Qin</name></author><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Chin, Fy" uniqKey="Chin F">FY Chin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Leung, Hc" uniqKey="Leung H">HC Leung</name></author><author><name sortKey="Yiu, S M" uniqKey="Yiu S">S-M Yiu</name></author><author><name sortKey="Chin, Fy" uniqKey="Chin F">FY Chin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Leung, Hc" uniqKey="Leung H">HC Leung</name></author><author><name sortKey="Yiu, S M" uniqKey="Yiu S">S-M Yiu</name></author><author><name sortKey="Chin, Fy" uniqKey="Chin F">FY Chin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Leung, Hc" uniqKey="Leung H">HC Leung</name></author><author><name sortKey="Yiu, Sm" uniqKey="Yiu S">SM Yiu</name></author><author><name sortKey="Chin, Fy" uniqKey="Chin F">FY Chin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liao, R" uniqKey="Liao R">R Liao</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Guan, J" uniqKey="Guan J">J Guan</name></author><author><name sortKey="Zhou, S" uniqKey="Zhou S">S Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blei, D" uniqKey="Blei D">D Blei</name></author><author><name sortKey="Ng, A" uniqKey="Ng A">A Ng</name></author><author><name sortKey="Jordan, M" uniqKey="Jordan M">M Jordan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frigui, H" uniqKey="Frigui H">H Frigui</name></author><author><name sortKey="Nasraoui, O" uniqKey="Nasraoui O">O Nasraoui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aso, T" uniqKey="Aso T">T Aso</name></author><author><name sortKey="Eguchi, K" uniqKey="Eguchi K">K Eguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, B" uniqKey="Zheng B">B Zheng</name></author><author><name sortKey="Mclean, Dc" uniqKey="Mclean D">DC McLean</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerber, Gk" uniqKey="Gerber G">GK Gerber</name></author><author><name sortKey="Dowell, Rd" uniqKey="Dowell R">RD Dowell</name></author><author><name sortKey="Jaakkola, Ts" uniqKey="Jaakkola T">TS Jaakkola</name></author><author><name sortKey="Gifford, Dk" uniqKey="Gifford D">DK Gifford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name></author><author><name sortKey="Lim, Ty" uniqKey="Lim T">TY Lim</name></author><author><name sortKey="Shen, X" uniqKey="Shen X">X Shen</name></author><author><name sortKey="Park, E" uniqKey="Park E">E Park</name></author><author><name sortKey="Rosen, Gl" uniqKey="Rosen G">GL Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chor, B" uniqKey="Chor B">B Chor</name></author><author><name sortKey="Horn, D" uniqKey="Horn D">D Horn</name></author><author><name sortKey="Goldman, N" uniqKey="Goldman N">N Goldman</name></author><author><name sortKey="Levy, Y" uniqKey="Levy Y">Y Levy</name></author><author><name sortKey="Massingham, T" uniqKey="Massingham T">T Massingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, F" uniqKey="Zhou F">F Zhou</name></author><author><name sortKey="Olman, V" uniqKey="Olman V">V Olman</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griffiths, Tl" uniqKey="Griffiths T">TL Griffiths</name></author><author><name sortKey="Steyvers, M" uniqKey="Steyvers M">M Steyvers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richter, Dc" uniqKey="Richter D">DC Richter</name></author><author><name sortKey="Ott, F" uniqKey="Ott F">F Ott</name></author><author><name sortKey="Auch, Af" uniqKey="Auch A">AF Auch</name></author><author><name sortKey="Schmid, R" uniqKey="Schmid R">R Schmid</name></author><author><name sortKey="Huson, Dh" uniqKey="Huson D">DH Huson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tyson, Gw" uniqKey="Tyson G">GW Tyson</name></author><author><name sortKey="Chapman, J" uniqKey="Chapman J">J Chapman</name></author><author><name sortKey="Hugenholtz, P" uniqKey="Hugenholtz P">P Hugenholtz</name></author><author><name sortKey="Allen, Ee" uniqKey="Allen E">EE Allen</name></author><author><name sortKey="Ram, Rj" uniqKey="Ram R">RJ Ram</name></author><author><name sortKey="Richardson, Pm" uniqKey="Richardson P">PM Richardson</name></author><author><name sortKey="Solovyev, Vv" uniqKey="Solovyev V">VV Solovyev</name></author><author><name sortKey="Rubin, Em" uniqKey="Rubin E">EM Rubin</name></author><author><name sortKey="Rokhsar, Ds" uniqKey="Rokhsar D">DS Rokhsar</name></author><author><name sortKey="Banfield, Jf" uniqKey="Banfield J">JF Banfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larsen, B" uniqKey="Larsen 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