Middle East respiratory syndrome: obstacles and prospects for vaccine development
Identifieur interne : 001667 ( Main/Merge ); précédent : 001666; suivant : 001668Middle East respiratory syndrome: obstacles and prospects for vaccine development
Auteurs : Amy B. Papaneri ; Reed F. Johnson ; Jiro Wada ; Laura Bollinger ; Peter B. Jahrling ; Jens H. KuhnSource :
- Expert Review of Vaccines [ 1476-0584 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Découverte de médicament (tendances), Découverte de médicament (économie), Essais cliniques comme sujet, Humains, Infections à coronavirus (), Modèles animaux de maladie humaine, Vaccins antiviraux (immunologie), Vaccins antiviraux (isolement et purification), Évaluation préclinique de médicament (), Évaluation préclinique de médicament (économie).
- MESH :
- immunologie : Vaccins antiviraux.
- isolement et purification : Vaccins antiviraux.
- tendances : Découverte de médicament.
- économie : Découverte de médicament, Évaluation préclinique de médicament.
- Animaux, Essais cliniques comme sujet, Humains, Infections à coronavirus, Modèles animaux de maladie humaine, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Animals, Clinical Trials as Topic, Coronavirus Infections (prevention & control), Disease Models, Animal, Drug Discovery (economics), Drug Discovery (trends), Drug Evaluation, Preclinical (economics), Drug Evaluation, Preclinical (methods), Humans, Viral Vaccines (immunology), Viral Vaccines (isolation & purification).
- MESH :
- chemical , immunology : Viral Vaccines.
- economics : Drug Discovery, Drug Evaluation, Preclinical.
- chemical , isolation & purification : Viral Vaccines.
- methods : Drug Evaluation, Preclinical.
- prevention & control : Coronavirus Infections.
- trends : Drug Discovery.
- Animals, Clinical Trials as Topic, Disease Models, Animal, Humans.
Abstract
The recent emergence of Middle East respiratory syndrome (MERS) highlights the need to engineer new methods for expediting vaccine development against emerging diseases. However, several obstacles prevent pursuit of a licensable MERS vaccine. First, the lack of a suitable animal model for MERS complicates the
Url:
DOI: 10.1586/14760584.2015.1036033
PubMed: 25864502
PubMed Central: 4832601
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PMC:4832601Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The recent emergence of Middle East respiratory syndrome (MERS) highlights the need to engineer new methods for expediting vaccine development against emerging diseases. However, several obstacles prevent pursuit of a licensable MERS vaccine. First, the lack of a suitable animal model for MERS complicates the <italic>in vivo</italic>
testing of candidate vaccines. Second, due to the low number of MERS cases, pharmaceutical companies have little incentive to pursue MERS vaccine production as the costs of clinical trials are high. In addition, the timeline from bench research to approved vaccine use is 10 years or longer. Using novel methods and cost-saving strategies, genetically engineered vaccines can be produced quickly and cost-effectively. Along with progress in MERS animal model development, these obstacles can be circumvented or at least mitigated.</p>
</div>
</front>
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