MersV1, Main, Merge, bibRecord, 000A16

Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.

Identifieur interne : 000A16 ( Main/Merge ); précédent : 000A15; suivant : 000A17

Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.

Auteurs : Sayed Sartaj Sohrab [Arabie saoudite] ; Sherif Aly El-Kafrawy [Arabie saoudite] ; Zeenat Mirza [Arabie saoudite] ; Mohammad Amjad Kamal [Arabie saoudite] ; Esam Ibraheem Azhar [Arabie saoudite]

Source :

Current pharmaceutical design [ 1873-4286 ] ; 2018.

RBID : pubmed:29119921

Descripteurs français

KwdFr :
- Conception de médicament, Coronavirus du syndrome respiratoire du Moyen-Orient (), Humains, Petit ARN interférent (pharmacologie), Systèmes de délivrance de médicaments.
MESH :
- pharmacologie : Petit ARN interférent.
- Conception de médicament, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Systèmes de délivrance de médicaments.

English descriptors

KwdEn :
- Drug Delivery Systems, Drug Design, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), RNA, Small Interfering (pharmacology).
MESH :
- chemical , pharmacology : RNA, Small Interfering.
- drug effects : Middle East Respiratory Syndrome Coronavirus.
- Drug Delivery Systems, Drug Design, Humans.

Abstract

The MERS-CoV is a novel human coronavirus causing respiratory syndrome since April 2012. The replication of MERS-CoV is mediated by ORF 1ab and viral gene activity can be modulated by RNAi approach. The inhibition of virus replication has been documented in cell culture against multiple viruses by RNAi approach. Currently, very few siRNA against MERS-CoV have been computationally designed and published.

DOI: 10.2174/1381612823666171109112307
PubMed: 29119921

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000A93
to stream PubMed, to step Curation: 000A93
to stream PubMed, to step Checkpoint: 000957
to stream Ncbi, to step Merge: 001C40
to stream Ncbi, to step Curation: 001C40
to stream Ncbi, to step Checkpoint: 001C40

Links to Exploration step

pubmed:29119921

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.</title>
<author><name sortKey="Sohrab, Sayed Sartaj" sort="Sohrab, Sayed Sartaj" uniqKey="Sohrab S" first="Sayed Sartaj" last="Sohrab">Sayed Sartaj Sohrab</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="El Kafrawy, Sherif Aly" sort="El Kafrawy, Sherif Aly" uniqKey="El Kafrawy S" first="Sherif Aly" last="El-Kafrawy">Sherif Aly El-Kafrawy</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mirza, Zeenat" sort="Mirza, Zeenat" uniqKey="Mirza Z" first="Zeenat" last="Mirza">Zeenat Mirza</name>
<affiliation wicri:level="1"><nlm:affiliation>King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kamal, Mohammad Amjad" sort="Kamal, Mohammad Amjad" uniqKey="Kamal M" first="Mohammad Amjad" last="Kamal">Mohammad Amjad Kamal</name>
<affiliation wicri:level="1"><nlm:affiliation>King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Azhar, Esam Ibraheem" sort="Azhar, Esam Ibraheem" uniqKey="Azhar E" first="Esam Ibraheem" last="Azhar">Esam Ibraheem Azhar</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29119921</idno>
<idno type="pmid">29119921</idno>
<idno type="doi">10.2174/1381612823666171109112307</idno>
<idno type="wicri:Area/PubMed/Corpus">000A93</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A93</idno>
<idno type="wicri:Area/PubMed/Curation">000A93</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A93</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000957</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000957</idno>
<idno type="wicri:Area/Ncbi/Merge">001C40</idno>
<idno type="wicri:Area/Ncbi/Curation">001C40</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C40</idno>
<idno type="wicri:Area/Main/Merge">000A16</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.</title>
<author><name sortKey="Sohrab, Sayed Sartaj" sort="Sohrab, Sayed Sartaj" uniqKey="Sohrab S" first="Sayed Sartaj" last="Sohrab">Sayed Sartaj Sohrab</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="El Kafrawy, Sherif Aly" sort="El Kafrawy, Sherif Aly" uniqKey="El Kafrawy S" first="Sherif Aly" last="El-Kafrawy">Sherif Aly El-Kafrawy</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mirza, Zeenat" sort="Mirza, Zeenat" uniqKey="Mirza Z" first="Zeenat" last="Mirza">Zeenat Mirza</name>
<affiliation wicri:level="1"><nlm:affiliation>King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kamal, Mohammad Amjad" sort="Kamal, Mohammad Amjad" uniqKey="Kamal M" first="Mohammad Amjad" last="Kamal">Mohammad Amjad Kamal</name>
<affiliation wicri:level="1"><nlm:affiliation>King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Azhar, Esam Ibraheem" sort="Azhar, Esam Ibraheem" uniqKey="Azhar E" first="Esam Ibraheem" last="Azhar">Esam Ibraheem Azhar</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea>
<wicri:noRegion>Jeddah</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Current pharmaceutical design</title>
<idno type="eISSN">1873-4286</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Drug Delivery Systems</term>
<term>Drug Design</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>RNA, Small Interfering (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Conception de médicament</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Humains</term>
<term>Petit ARN interférent (pharmacologie)</term>
<term>Systèmes de délivrance de médicaments</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Petit ARN interférent</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Drug Delivery Systems</term>
<term>Drug Design</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Conception de médicament</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Humains</term>
<term>Systèmes de délivrance de médicaments</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The MERS-CoV is a novel human coronavirus causing respiratory syndrome since April 2012. The replication of MERS-CoV is mediated by ORF 1ab and viral gene activity can be modulated by RNAi approach. The inhibition of virus replication has been documented in cell culture against multiple viruses by RNAi approach. Currently, very few siRNA against MERS-CoV have been computationally designed and published.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A16 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000A16 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:29119921
   |texte=   Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:29119921" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.

Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki