Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.
Identifieur interne : 000A16 ( Main/Merge ); précédent : 000A15; suivant : 000A17Design and Delivery of Therapeutic siRNAs: Application to MERS-Coronavirus.
Auteurs : Sayed Sartaj Sohrab [Arabie saoudite] ; Sherif Aly El-Kafrawy [Arabie saoudite] ; Zeenat Mirza [Arabie saoudite] ; Mohammad Amjad Kamal [Arabie saoudite] ; Esam Ibraheem Azhar [Arabie saoudite]Source :
- Current pharmaceutical design [ 1873-4286 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : RNA, Small Interfering.
- drug effects : Middle East Respiratory Syndrome Coronavirus.
- Drug Delivery Systems, Drug Design, Humans.
Abstract
The MERS-CoV is a novel human coronavirus causing respiratory syndrome since April 2012. The replication of MERS-CoV is mediated by ORF 1ab and viral gene activity can be modulated by RNAi approach. The inhibition of virus replication has been documented in cell culture against multiple viruses by RNAi approach. Currently, very few siRNA against MERS-CoV have been computationally designed and published.
DOI: 10.2174/1381612823666171109112307
PubMed: 29119921
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pubmed:29119921Le document en format XML
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<front><div type="abstract" xml:lang="en">The MERS-CoV is a novel human coronavirus causing respiratory syndrome since April 2012. The replication of MERS-CoV is mediated by ORF 1ab and viral gene activity can be modulated by RNAi approach. The inhibition of virus replication has been documented in cell culture against multiple viruses by RNAi approach. Currently, very few siRNA against MERS-CoV have been computationally designed and published.</div>
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