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Human β-defensin 2 is involved in CCR2-mediated Nod2 signal transduction, leading to activation of the innate immune response in macrophages

Identifieur interne : 000546 ( Main/Merge ); précédent : 000545; suivant : 000547

Human β-defensin 2 is involved in CCR2-mediated Nod2 signal transduction, leading to activation of the innate immune response in macrophages

Auteurs : Ju Kim [Corée du Sud] ; Ye Lin Yang [Corée du Sud] ; Yong-Suk Jang [Corée du Sud]

Source :

RBID : PMC:7114636

Descripteurs français

English descriptors

Abstract

Highlights

HBD 2 enhanced the innate antiviral immune response, including type I IFN induction.

This enhancement was mediated by CCR2-involved and Nod2-mediated signaling.

HBD 2 induced the activation and M1 polarization of macrophage-like THP-1 cells.


Url:
DOI: 10.1016/j.imbio.2019.05.004
PubMed: 31126693
PubMed Central: 7114636

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PMC:7114636

Le document en format XML

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<term>Host-Pathogen Interactions (immunology)</term>
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<term>Immunité innée</term>
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