MersV1, Main, Merge, bibRecord, 000127

Outcome of Oncology Patients Infected With Coronavirus

Identifieur interne : 000127 ( Main/Merge ); précédent : 000126; suivant : 000128

Outcome of Oncology Patients Infected With Coronavirus

Auteurs : Abdul-Rahman Jazieh ; Thamer H. Alenazi ; Ayman Alhejazi ; Faisal Al Safi ; Ashwaq Al Olayan

Source :

JCO Global Oncology [ 2687-8941 ] ; 2020.

RBID : PMC:7124938

Abstract

PURPOSE

This study investigated the features of oncology patients with confirmed Middle East respiratory syndrome (MERS) at the Ministry of National Guard Health Affairs-Riyadh during the outbreak of June 2015 to determine the clinical course and outcome of affected patients.

METHODS

The patients’ demographic information, cancer history, treatment pattern, information about MERS-coronavirus (CoV) infection, history of travel, clinical symptoms, test results, and outcome were collected and analyzed as part of a quality improvement project to improve the care and safety of our patients. Only patients with confirmed infection were included.

RESULTS

A total of 19 patients were identified, with a median age of 66 years (range, 16-88 years), and 12 patients (63%) were males. The most common underlying disease was hematologic malignancies (47.4%), followed by colorectal cancer (21%) and lung cancer (15.8%). Hypertension and diabetes mellitus were the most common comorbidities (57.9% and 52.6%, respectively). Infection was diagnosed by nasopharyngeal swab in all patients. All patients contracted the infection during their hospitalization for other reasons. Sixteen patients (80%) were admitted to the intensive care unit; 13 patients (81%) had acute respiratory distress syndrome, 11 were intubated (68.75%), 9 had acute renal injury (56.25%), and 3 required dialysis (18.75%). Only 3 patients (15.8%) with early-stage cancers survived. Patients with hematologic malignancies and advanced solid tumors had a 100% case fatality rate. The majority of the causes of death were due to multi-organ failure and septic shock.

CONCLUSION

MERS-CoV infection resulted in a high case fatality rate in patients with malignancy. Therefore, it is critical to implement effective primary preventive measures to avoid exposure of patients with cancer to the virus.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124938

DOI: 10.1200/GO.20.00064
PubMed: 32196389
PubMed Central: 7124938

Links to Exploration step

PMC:7124938

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<front><div type="abstract" xml:lang="en"><sec><title>PURPOSE</title>
<p>This study investigated the features of oncology patients with confirmed Middle East respiratory syndrome (MERS) at the Ministry of National Guard Health Affairs-Riyadh during the outbreak of June 2015 to determine the clinical course and outcome of affected patients.</p>
</sec>
<sec><title>METHODS</title>
<p>The patients’ demographic information, cancer history, treatment pattern, information about MERS-coronavirus (CoV) infection, history of travel, clinical symptoms, test results, and outcome were collected and analyzed as part of a quality improvement project to improve the care and safety of our patients. Only patients with confirmed infection were included.</p>
</sec>
<sec><title>RESULTS</title>
<p>A total of 19 patients were identified, with a median age of 66 years (range, 16-88 years), and 12 patients (63%) were males. The most common underlying disease was hematologic malignancies (47.4%), followed by colorectal cancer (21%) and lung cancer (15.8%). Hypertension and diabetes mellitus were the most common comorbidities (57.9% and 52.6%, respectively). Infection was diagnosed by nasopharyngeal swab in all patients. All patients contracted the infection during their hospitalization for other reasons. Sixteen patients (80%) were admitted to the intensive care unit; 13 patients (81%) had acute respiratory distress syndrome, 11 were intubated (68.75%), 9 had acute renal injury (56.25%), and 3 required dialysis (18.75%). Only 3 patients (15.8%) with early-stage cancers survived. Patients with hematologic malignancies and advanced solid tumors had a 100% case fatality rate. The majority of the causes of death were due to multi-organ failure and septic shock.</p>
</sec>
<sec><title>CONCLUSION</title>
<p>MERS-CoV infection resulted in a high case fatality rate in patients with malignancy. Therefore, it is critical to implement effective primary preventive measures to avoid exposure of patients with cancer to the virus.</p>
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Outcome of Oncology Patients Infected With Coronavirus

Outcome of Oncology Patients Infected With Coronavirus

Source :

Abstract

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