Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016
Identifieur interne : 000A40 ( Main/Exploration ); précédent : 000A39; suivant : 000A41Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016
Auteurs : A. Bleibtreu [France] ; S. Jaureguiberry [France] ; N. Houhou [France] ; D. Boutolleau [France] ; H. Guillot [France] ; D. Vallois [France] ; J. C. Lucet [France] ; J. Robert [France] ; B. Mourvillier [France] ; J. Delemazure [France] ; M. Jaspard [France] ; F. X. Lescure [France] ; C. Rioux [France] ; E. Caumes [France] ; Y. Yazdanapanah [France]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antibactériens (usage thérapeutique), Antiviraux (usage thérapeutique), Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Hospitalisation, Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Isolement du patient, Mâle, Oséltamivir (usage thérapeutique), Oxygénothérapie, Paris, Résultat thérapeutique, Streptococcus pneumoniae, Sujet âgé, Voyage, Études rétrospectives.
- MESH :
- diagnostic : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- usage thérapeutique : Antibactériens, Antiviraux, Oséltamivir.
- virologie : Infections à coronavirus.
- Adulte d'âge moyen, Arabie saoudite, Femelle, Hospitalisation, Humains, Infections à coronavirus, Isolement du patient, Mâle, Oxygénothérapie, Paris, Résultat thérapeutique, Streptococcus pneumoniae, Sujet âgé, Voyage, Études rétrospectives.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Aged, Anti-Bacterial Agents (therapeutic use), Antiviral Agents (therapeutic use), Coronavirus Infections (diagnosis), Coronavirus Infections (therapy), Coronavirus Infections (virology), Female, Hospitalization, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Oseltamivir (therapeutic use), Oxygen Inhalation Therapy, Paris, Patient Isolation, Retrospective Studies, Saudi Arabia, Streptococcus pneumoniae, Travel, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Antiviral Agents, Oseltamivir.
- geographic : Paris, Saudi Arabia.
- diagnosis : Coronavirus Infections.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- therapy : Coronavirus Infections.
- virology : Coronavirus Infections.
- Aged, Female, Hospitalization, Humans, Male, Middle Aged, Oxygen Inhalation Therapy, Patient Isolation, Retrospective Studies, Streptococcus pneumoniae, Travel, Treatment Outcome.
- mix :
Abstract
Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV.
We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016.
Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one
The management of patients with possible MERS-CoV infection requires medical facilities with trained personnel, and rapid access to virological results. Empirical treatment with neuraminidase inhibitors and an association of antibiotics effective against
The online version of this article (10.1186/s12879-018-3223-5) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12879-018-3223-5
PubMed: 30012113
PubMed Central: 6048819
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016</title>
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Paris, France</nlm:aff>
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Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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</author>
<author><name sortKey="Jaureguiberry, S" sort="Jaureguiberry, S" uniqKey="Jaureguiberry S" first="S." last="Jaureguiberry">S. Jaureguiberry</name>
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Paris, France</nlm:aff>
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<author><name sortKey="Houhou, N" sort="Houhou, N" uniqKey="Houhou N" first="N." last="Houhou">N. Houhou</name>
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<institution>Virology Department,</institution>
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Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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<author><name sortKey="Boutolleau, D" sort="Boutolleau, D" uniqKey="Boutolleau D" first="D." last="Boutolleau">D. Boutolleau</name>
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Paris, France</nlm:aff>
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<author><name sortKey="Guillot, H" sort="Guillot, H" uniqKey="Guillot H" first="H." last="Guillot">H. Guillot</name>
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Paris, France</nlm:aff>
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<author><name sortKey="Vallois, D" sort="Vallois, D" uniqKey="Vallois D" first="D." last="Vallois">D. Vallois</name>
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Paris, France</nlm:aff>
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<author><name sortKey="Lucet, J C" sort="Lucet, J C" uniqKey="Lucet J" first="J. C." last="Lucet">J. C. Lucet</name>
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<institution>Paris Diderot University,</institution>
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Paris, France</nlm:aff>
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Paris, France</nlm:aff>
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Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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<author><name sortKey="Robert, J" sort="Robert, J" uniqKey="Robert J" first="J." last="Robert">J. Robert</name>
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Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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<institution>Faculté de Médecine P. & M. Curie Paris-6 - Site Pitié,</institution>
<institution>Centre d’Immunologie et des Maladies Infectieuses (CIMI) - E13,</institution>
</institution-wrap>
Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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</affiliation>
</author>
<author><name sortKey="Mourvillier, B" sort="Mourvillier, B" uniqKey="Mourvillier B" first="B." last="Mourvillier">B. Mourvillier</name>
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Paris, France</nlm:aff>
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Paris, France</nlm:aff>
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<institution>APHP- Hôpital Bichat Claude Bernard,</institution>
<institution>Service de Réanimation médicale et Infectieuse,</institution>
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Paris, France</nlm:aff>
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<author><name sortKey="Delemazure, J" sort="Delemazure, J" uniqKey="Delemazure J" first="J." last="Delemazure">J. Delemazure</name>
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Paris, France</nlm:aff>
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<author><name sortKey="Jaspard, M" sort="Jaspard, M" uniqKey="Jaspard M" first="M." last="Jaspard">M. Jaspard</name>
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Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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<author><name sortKey="Lescure, F X" sort="Lescure, F X" uniqKey="Lescure F" first="F. X." last="Lescure">F. X. Lescure</name>
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Paris, France</nlm:aff>
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Paris, France</nlm:aff>
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<author><name sortKey="Rioux, C" sort="Rioux, C" uniqKey="Rioux C" first="C." last="Rioux">C. Rioux</name>
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Paris, France</nlm:aff>
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<author><name sortKey="Caumes, E" sort="Caumes, E" uniqKey="Caumes E" first="E." last="Caumes">E. Caumes</name>
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<institution>Service des Maladies Infectieuses et Tropicales,</institution>
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Paris, France</nlm:aff>
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<author><name sortKey="Yazdanapanah, Y" sort="Yazdanapanah, Y" uniqKey="Yazdanapanah Y" first="Y." last="Yazdanapanah">Y. Yazdanapanah</name>
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Paris, France</nlm:aff>
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<institution>Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité,</institution>
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Paris, France</nlm:aff>
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</analytic>
<series><title level="j">BMC Infectious Diseases</title>
<idno type="eISSN">1471-2334</idno>
<imprint><date when="2018">2018</date>
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<term>Anti-Bacterial Agents (therapeutic use)</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one <italic>Plasmodium falciparum</italic>
malaria. Microbiological analysis identified <italic>Rhinovirus</italic>
(27.9%), <italic>Influenza</italic>
virus (26.8%), <italic>Legionella pneumophila</italic>
(7.5%), <italic>Streptococcus pneumoniae</italic>
(7.5%), and non-MERS-coronavirus (6.4%). Antibiotics were initiated in 81 (87%) cases, with two antibiotics in 63 patients (67.7%). The median duration of hospitalization and isolation was 3 days (1–33) and 24 h (8–92), respectively. Time of isolation decreased over time (<italic>P</italic>
< 0.01). Two patients (2%) died.</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">The management of patients with possible MERS-CoV infection requires medical facilities with trained personnel, and rapid access to virological results. Empirical treatment with neuraminidase inhibitors and an association of antibiotics effective against <italic>S. pneumoniae</italic>
and <italic>L. pneumophila</italic>
are the cornerstones of the management of patients hospitalized for suspected MERS-CoV infection.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (10.1186/s12879-018-3223-5) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Osterhaus, Adme" uniqKey="Osterhaus A">ADME Osterhaus</name>
</author>
<author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name>
</author>
</analytic>
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