Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-β through Its Deubiquitinase Activity
Identifieur interne : 000B37 ( Main/Exploration ); précédent : 000B36; suivant : 000B38Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-β through Its Deubiquitinase Activity
Auteurs : Xiaoliang Hu [République populaire de Chine] ; Jin Tian [République populaire de Chine] ; Hongtao Kang [République populaire de Chine] ; Dongchun Guo [République populaire de Chine] ; Jiasen Liu [République populaire de Chine] ; Dafei Liu [République populaire de Chine] ; Qian Jiang [République populaire de Chine] ; Zhijie Li [République populaire de Chine] ; Juanjuan Qu [République populaire de Chine] ; Liandong Qu [République populaire de Chine]Source :
- BioMed Research International [ 2314-6133 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Cellules HEK293, Enzymes de désubiquitinylation (génétique), Facteur-3 de régulation d'interféron (génétique), Humains, Immunité innée (génétique), Interactions hôte-pathogène (génétique), Interféron bêta (biosynthèse), Interféron bêta (génétique), Papaïne (), Papaïne (génétique), Papaïne (immunologie), Protéine-58 à domaine DEAD (génétique), Protéines membranaires (génétique), RNA replicase (génétique), Suidae, Ubiquitine (génétique), Virus de la gastroentérite transmissible (), Virus de la gastroentérite transmissible (génétique), Virus de la gastroentérite transmissible (pathogénicité).
- MESH :
- biosynthèse : Interféron bêta.
- génétique : Enzymes de désubiquitinylation, Facteur-3 de régulation d'interféron, Immunité innée, Interactions hôte-pathogène, Interféron bêta, Papaïne, Protéine-58 à domaine DEAD, Protéines membranaires, RNA replicase, Ubiquitine, Virus de la gastroentérite transmissible.
- immunologie : Papaïne.
- pathogénicité : Virus de la gastroentérite transmissible.
- Animaux, Cellules HEK293, Humains, Papaïne, Suidae, Virus de la gastroentérite transmissible.
English descriptors
- KwdEn :
- Animals, DEAD Box Protein 58 (genetics), Deubiquitinating Enzymes (genetics), HEK293 Cells, Host-Pathogen Interactions (genetics), Humans, Immunity, Innate (genetics), Interferon Regulatory Factor-3 (genetics), Interferon-beta (biosynthesis), Interferon-beta (genetics), Membrane Proteins (genetics), Papain (chemistry), Papain (genetics), Papain (immunology), RNA Replicase (genetics), Swine, Transmissible gastroenteritis virus (chemistry), Transmissible gastroenteritis virus (genetics), Transmissible gastroenteritis virus (pathogenicity), Ubiquitin (genetics).
- MESH :
- chemical , biosynthesis : Interferon-beta.
- chemical , chemistry : Papain.
- chemical , genetics : DEAD Box Protein 58, Deubiquitinating Enzymes, Interferon Regulatory Factor-3, Interferon-beta, Membrane Proteins, Papain, RNA Replicase, Ubiquitin.
- chemistry : Transmissible gastroenteritis virus.
- genetics : Host-Pathogen Interactions, Immunity, Innate, Transmissible gastroenteritis virus.
- chemical , immunology : Papain.
- pathogenicity : Transmissible gastroenteritis virus.
- Animals, HEK293 Cells, Humans, Swine.
Abstract
Coronaviruses (CoVs), such as human coronavirus NL63 (HCoV-NL63), severe acute respiratory syndrome CoV (SARS-CoV), murine hepatitis virus (MHV), porcine epidemic diarrhea virus (PEDV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), encode papain-like (PL) proteases that inhibit Sendai virus- (SeV-) induced interferon (IFN-
Url:
DOI: 10.1155/2017/7089091
PubMed: 29201911
PubMed Central: 5672592
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B33
- to stream Pmc, to step Curation: 000B33
- to stream Pmc, to step Checkpoint: 000682
- to stream PubMed, to step Corpus: 000A61
- to stream PubMed, to step Curation: 000A61
- to stream PubMed, to step Checkpoint: 000A78
- to stream Ncbi, to step Merge: 001C71
- to stream Ncbi, to step Curation: 001C71
- to stream Ncbi, to step Checkpoint: 001C71
- to stream Main, to step Merge: 000B40
- to stream Main, to step Curation: 000B37
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-<italic>β</italic>
through Its Deubiquitinase Activity</title>
<author><name sortKey="Hu, Xiaoliang" sort="Hu, Xiaoliang" uniqKey="Hu X" first="Xiaoliang" last="Hu">Xiaoliang Hu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tian, Jin" sort="Tian, Jin" uniqKey="Tian J" first="Jin" last="Tian">Jin Tian</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kang, Hongtao" sort="Kang, Hongtao" uniqKey="Kang H" first="Hongtao" last="Kang">Hongtao Kang</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Dongchun" sort="Guo, Dongchun" uniqKey="Guo D" first="Dongchun" last="Guo">Dongchun Guo</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jiasen" sort="Liu, Jiasen" uniqKey="Liu J" first="Jiasen" last="Liu">Jiasen Liu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Dafei" sort="Liu, Dafei" uniqKey="Liu D" first="Dafei" last="Liu">Dafei Liu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Qian" sort="Jiang, Qian" uniqKey="Jiang Q" first="Qian" last="Jiang">Qian Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Zhijie" sort="Li, Zhijie" uniqKey="Li Z" first="Zhijie" last="Li">Zhijie Li</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qu, Juanjuan" sort="Qu, Juanjuan" uniqKey="Qu J" first="Juanjuan" last="Qu">Juanjuan Qu</name>
<affiliation wicri:level="1"><nlm:aff id="I2">College of Life Science, Northeast Agricultural University, Harbin, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Life Science, Northeast Agricultural University, Harbin</wicri:regionArea>
<wicri:noRegion>Harbin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qu, Liandong" sort="Qu, Liandong" uniqKey="Qu L" first="Liandong" last="Qu">Liandong Qu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">29201911</idno>
<idno type="pmc">5672592</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672592</idno>
<idno type="RBID">PMC:5672592</idno>
<idno type="doi">10.1155/2017/7089091</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">000B33</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B33</idno>
<idno type="wicri:Area/Pmc/Curation">000B33</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B33</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000682</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000682</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:29201911</idno>
<idno type="wicri:Area/PubMed/Corpus">000A61</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A61</idno>
<idno type="wicri:Area/PubMed/Curation">000A61</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A61</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000A78</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A78</idno>
<idno type="wicri:Area/Ncbi/Merge">001C71</idno>
<idno type="wicri:Area/Ncbi/Curation">001C71</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C71</idno>
<idno type="wicri:doubleKey">2314-6133:2017:Hu X:transmissible:gastroenteritis:virus</idno>
<idno type="wicri:Area/Main/Merge">000B40</idno>
<idno type="wicri:Area/Main/Curation">000B37</idno>
<idno type="wicri:Area/Main/Exploration">000B37</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-<italic>β</italic>
through Its Deubiquitinase Activity</title>
<author><name sortKey="Hu, Xiaoliang" sort="Hu, Xiaoliang" uniqKey="Hu X" first="Xiaoliang" last="Hu">Xiaoliang Hu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tian, Jin" sort="Tian, Jin" uniqKey="Tian J" first="Jin" last="Tian">Jin Tian</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kang, Hongtao" sort="Kang, Hongtao" uniqKey="Kang H" first="Hongtao" last="Kang">Hongtao Kang</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Dongchun" sort="Guo, Dongchun" uniqKey="Guo D" first="Dongchun" last="Guo">Dongchun Guo</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jiasen" sort="Liu, Jiasen" uniqKey="Liu J" first="Jiasen" last="Liu">Jiasen Liu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Dafei" sort="Liu, Dafei" uniqKey="Liu D" first="Dafei" last="Liu">Dafei Liu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Qian" sort="Jiang, Qian" uniqKey="Jiang Q" first="Qian" last="Jiang">Qian Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Zhijie" sort="Li, Zhijie" uniqKey="Li Z" first="Zhijie" last="Li">Zhijie Li</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qu, Juanjuan" sort="Qu, Juanjuan" uniqKey="Qu J" first="Juanjuan" last="Qu">Juanjuan Qu</name>
<affiliation wicri:level="1"><nlm:aff id="I2">College of Life Science, Northeast Agricultural University, Harbin, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Life Science, Northeast Agricultural University, Harbin</wicri:regionArea>
<wicri:noRegion>Harbin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qu, Liandong" sort="Qu, Liandong" uniqKey="Qu L" first="Liandong" last="Qu">Liandong Qu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001</wicri:regionArea>
<wicri:noRegion>Harbin 150001</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">BioMed Research International</title>
<idno type="ISSN">2314-6133</idno>
<idno type="eISSN">2314-6141</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>DEAD Box Protein 58 (genetics)</term>
<term>Deubiquitinating Enzymes (genetics)</term>
<term>HEK293 Cells</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Humans</term>
<term>Immunity, Innate (genetics)</term>
<term>Interferon Regulatory Factor-3 (genetics)</term>
<term>Interferon-beta (biosynthesis)</term>
<term>Interferon-beta (genetics)</term>
<term>Membrane Proteins (genetics)</term>
<term>Papain (chemistry)</term>
<term>Papain (genetics)</term>
<term>Papain (immunology)</term>
<term>RNA Replicase (genetics)</term>
<term>Swine</term>
<term>Transmissible gastroenteritis virus (chemistry)</term>
<term>Transmissible gastroenteritis virus (genetics)</term>
<term>Transmissible gastroenteritis virus (pathogenicity)</term>
<term>Ubiquitin (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules HEK293</term>
<term>Enzymes de désubiquitinylation (génétique)</term>
<term>Facteur-3 de régulation d'interféron (génétique)</term>
<term>Humains</term>
<term>Immunité innée (génétique)</term>
<term>Interactions hôte-pathogène (génétique)</term>
<term>Interféron bêta (biosynthèse)</term>
<term>Interféron bêta (génétique)</term>
<term>Papaïne ()</term>
<term>Papaïne (génétique)</term>
<term>Papaïne (immunologie)</term>
<term>Protéine-58 à domaine DEAD (génétique)</term>
<term>Protéines membranaires (génétique)</term>
<term>RNA replicase (génétique)</term>
<term>Suidae</term>
<term>Ubiquitine (génétique)</term>
<term>Virus de la gastroentérite transmissible ()</term>
<term>Virus de la gastroentérite transmissible (génétique)</term>
<term>Virus de la gastroentérite transmissible (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-beta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Papain</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DEAD Box Protein 58</term>
<term>Deubiquitinating Enzymes</term>
<term>Interferon Regulatory Factor-3</term>
<term>Interferon-beta</term>
<term>Membrane Proteins</term>
<term>Papain</term>
<term>RNA Replicase</term>
<term>Ubiquitin</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron bêta</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Transmissible gastroenteritis virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Host-Pathogen Interactions</term>
<term>Immunity, Innate</term>
<term>Transmissible gastroenteritis virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Enzymes de désubiquitinylation</term>
<term>Facteur-3 de régulation d'interféron</term>
<term>Immunité innée</term>
<term>Interactions hôte-pathogène</term>
<term>Interféron bêta</term>
<term>Papaïne</term>
<term>Protéine-58 à domaine DEAD</term>
<term>Protéines membranaires</term>
<term>RNA replicase</term>
<term>Ubiquitine</term>
<term>Virus de la gastroentérite transmissible</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Papaïne</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Papain</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Transmissible gastroenteritis virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la gastroentérite transmissible</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules HEK293</term>
<term>Humains</term>
<term>Papaïne</term>
<term>Suidae</term>
<term>Virus de la gastroentérite transmissible</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Coronaviruses (CoVs), such as human coronavirus NL63 (HCoV-NL63), severe acute respiratory syndrome CoV (SARS-CoV), murine hepatitis virus (MHV), porcine epidemic diarrhea virus (PEDV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), encode papain-like (PL) proteases that inhibit Sendai virus- (SeV-) induced interferon (IFN-<italic>β</italic>
) production. Recently, the crystal structure of transmissible gastroenteritis virus (TGEV) PL1 has been solved, which was similar to that of SARS-CoV PL2<sup>pro</sup>
, which may antagonize host innate immunity. However, very little is known about whether TGEV PL1 can antagonize host innate immune response. Here, we presented evidence that TGEV PL1 encoded by the replicase gene could suppress the IFN-<italic>β</italic>
expression and inhibit the nuclear translocation of interferon regulatory factor 3 (IRF3). The ability to antagonize IFN-<italic>β</italic>
production was dependent on the intact catalytic activity of PL1. Furthermore, TGEV PL1 exerted deubiquitinase (DUB) activity which strongly inhibited the retinoic acid-induced gene I- (RIG-1-) and stimulator of interferon gene- (STING-) dependent IFN expression. Our data collectively suggest that TGEV PL1 can inhibit the IFN-<italic>β</italic>
expression and interfere with RIG-1- and STING-mediated signaling through a viral DUB activity. Our study has yielded strong evidence for the TGEV PL1 mechanisms that counteract the host innate immunity.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kawai, T" uniqKey="Kawai T">T. Kawai</name>
</author>
<author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoneyama, M" uniqKey="Yoneyama M">M. Yoneyama</name>
</author>
<author><name sortKey="Fujita, T" uniqKey="Fujita T">T. Fujita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramos, H J" uniqKey="Ramos H">H. J. Ramos</name>
</author>
<author><name sortKey="Gale, M" uniqKey="Gale M">M. Gale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
<author><name sortKey="Smerdou, C" uniqKey="Smerdou C">C. Smerdou</name>
</author>
<author><name sortKey="Castilla, J" uniqKey="Castilla J">J. Castilla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name>
</author>
<author><name sortKey="Snijder, E J" uniqKey="Snijder E">E. J. Snijder</name>
</author>
<author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A. E. Gorbalenya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clementz, M A" uniqKey="Clementz M">M. A. Clementz</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
<author><name sortKey="Banach, B S" uniqKey="Banach B">B. S. Banach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zheng, D" uniqKey="Zheng D">D. Zheng</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name>
</author>
<author><name sortKey="Guo, B" uniqKey="Guo B">B. Guo</name>
</author>
<author><name sortKey="Cheng, G" uniqKey="Cheng G">G. Cheng</name>
</author>
<author><name sortKey="Tang, H" uniqKey="Tang H">H. Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Devaraj, S G" uniqKey="Devaraj S">S. G. Devaraj</name>
</author>
<author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barretto, N" uniqKey="Barretto N">N. Barretto</name>
</author>
<author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D. Jukneliene</name>
</author>
<author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
<author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A. D. Mesecar</name>
</author>
<author><name sortKey="Baker, S C" uniqKey="Baker S">S. C. Baker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mielech, A M" uniqKey="Mielech A">A. M. Mielech</name>
</author>
<author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A. Kilianski</name>
</author>
<author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y. M. Baez-Santos</name>
</author>
<author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A. D. Mesecar</name>
</author>
<author><name sortKey="Baker, S C" uniqKey="Baker S">S. C. Baker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wojdyla, J A" uniqKey="Wojdyla J">J. A. Wojdyla</name>
</author>
<author><name sortKey="Manolaridis, I" uniqKey="Manolaridis I">I. Manolaridis</name>
</author>
<author><name sortKey="Van Kasteren, P B" uniqKey="Van Kasteren P">P. B. Van Kasteren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name>
</author>
<author><name sortKey="Fang, L" uniqKey="Fang L">L. Fang</name>
</author>
<author><name sortKey="Li, T" uniqKey="Li T">T. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vaux, D L" uniqKey="Vaux D">D. L. Vaux</name>
</author>
<author><name sortKey="Fidler, F" uniqKey="Fidler F">F. Fidler</name>
</author>
<author><name sortKey="Cumming, G" uniqKey="Cumming G">G. Cumming</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xing, Y" uniqKey="Xing Y">Y. Xing</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
<author><name sortKey="Tu, J" uniqKey="Tu J">J. Tu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, W" uniqKey="Sun W">W. Sun</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhong, B" uniqKey="Zhong B">B. Zhong</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author><name sortKey="Li, S" uniqKey="Li S">S. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Albina, E" uniqKey="Albina E">E. Albina</name>
</author>
<author><name sortKey="Carrat, C" uniqKey="Carrat C">C. Carrat</name>
</author>
<author><name sortKey="Charley, B" uniqKey="Charley B">B. Charley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baudoux, P" uniqKey="Baudoux P">P. Baudoux</name>
</author>
<author><name sortKey="Carrat, C" uniqKey="Carrat C">C. Carrat</name>
</author>
<author><name sortKey="Besnardeau, L" uniqKey="Besnardeau L">L. Besnardeau</name>
</author>
<author><name sortKey="Charley, B" uniqKey="Charley B">B. Charley</name>
</author>
<author><name sortKey="Laude, H" uniqKey="Laude H">H. Laude</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z. Ding</name>
</author>
<author><name sortKey="An, K" uniqKey="An K">K. An</name>
</author>
<author><name sortKey="Xie, L" uniqKey="Xie L">L. Xie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, L" uniqKey="Zhu L">L. Zhu</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name>
</author>
<author><name sortKey="Mou, C" uniqKey="Mou C">C. Mou</name>
</author>
<author><name sortKey="Yang, Q" uniqKey="Yang Q">Q. Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bhoj, V G" uniqKey="Bhoj V">V. G. Bhoj</name>
</author>
<author><name sortKey="Chen, Z J" uniqKey="Chen Z">Z. J. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Isaacson, M K" uniqKey="Isaacson M">M. K. Isaacson</name>
</author>
<author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H. L. Ploegh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name>
</author>
<author><name sortKey="Fang, L" uniqKey="Fang L">L. Fang</name>
</author>
<author><name sortKey="Li, P" uniqKey="Li P">P. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, E T" uniqKey="Kim E">E. T. Kim</name>
</author>
<author><name sortKey="Oh, S E" uniqKey="Oh S">S. E. Oh</name>
</author>
<author><name sortKey="Lee, Y O" uniqKey="Lee Y">Y.-O. Lee</name>
</author>
<author><name sortKey="Gibson, W" uniqKey="Gibson W">W. Gibson</name>
</author>
<author><name sortKey="Ahn, J H" uniqKey="Ahn J">J.-H. Ahn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kattenhorn, L M" uniqKey="Kattenhorn L">L. M. Kattenhorn</name>
</author>
<author><name sortKey="Korbel, G A" uniqKey="Korbel G">G. A. Korbel</name>
</author>
<author><name sortKey="Kessler, B M" uniqKey="Kessler B">B. M. Kessler</name>
</author>
<author><name sortKey="Spooner, E" uniqKey="Spooner E">E. Spooner</name>
</author>
<author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H. L. Ploegh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
<author><name sortKey="Zhou, X" uniqKey="Zhou X">X. Zhou</name>
</author>
<author><name sortKey="Lunney, J K" uniqKey="Lunney J">J. K. Lunney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Z" uniqKey="Sun Z">Z. Sun</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
<author><name sortKey="Lawson, S R" uniqKey="Lawson S">S. R. Lawson</name>
</author>
<author><name sortKey="Fang, Y" uniqKey="Fang Y">Y. Fang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Hu, Xiaoliang" sort="Hu, Xiaoliang" uniqKey="Hu X" first="Xiaoliang" last="Hu">Xiaoliang Hu</name>
</noRegion>
<name sortKey="Guo, Dongchun" sort="Guo, Dongchun" uniqKey="Guo D" first="Dongchun" last="Guo">Dongchun Guo</name>
<name sortKey="Jiang, Qian" sort="Jiang, Qian" uniqKey="Jiang Q" first="Qian" last="Jiang">Qian Jiang</name>
<name sortKey="Kang, Hongtao" sort="Kang, Hongtao" uniqKey="Kang H" first="Hongtao" last="Kang">Hongtao Kang</name>
<name sortKey="Li, Zhijie" sort="Li, Zhijie" uniqKey="Li Z" first="Zhijie" last="Li">Zhijie Li</name>
<name sortKey="Liu, Dafei" sort="Liu, Dafei" uniqKey="Liu D" first="Dafei" last="Liu">Dafei Liu</name>
<name sortKey="Liu, Jiasen" sort="Liu, Jiasen" uniqKey="Liu J" first="Jiasen" last="Liu">Jiasen Liu</name>
<name sortKey="Qu, Juanjuan" sort="Qu, Juanjuan" uniqKey="Qu J" first="Juanjuan" last="Qu">Juanjuan Qu</name>
<name sortKey="Qu, Liandong" sort="Qu, Liandong" uniqKey="Qu L" first="Liandong" last="Qu">Liandong Qu</name>
<name sortKey="Tian, Jin" sort="Tian, Jin" uniqKey="Tian J" first="Jin" last="Tian">Jin Tian</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B37 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B37 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:5672592 |texte= Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-β through Its Deubiquitinase Activity }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29201911" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
This area was generated with Dilib version V0.6.33. |