The yeast UASG is a transcriptional enhancer in human hela cells in the presence of the GAL4 trans -activator
Identifieur interne : 004B98 ( Main/Exploration ); précédent : 004B97; suivant : 004B99The yeast UASG is a transcriptional enhancer in human hela cells in the presence of the GAL4 trans -activator
Auteurs : Nicholas Webster ; Jia Rui Jin [France] ; Stephen Green [France] ; Melvyn Hollis [États-Unis] ; Pierre Chambon [France]Source :
- Cell [ 0092-8674 ] ; 1988.
Descripteurs français
- KwdFr :
- ADN fongique (génétique), ADN recombiné, Animaux, Cellules HeLa (métabolisme), Facteurs de transcription, Globines (génétique), Humains, Lapins, Oestrogènes (pharmacologie), Plasmides, Protéines de Saccharomyces cerevisiae, Protéines de liaison à l'ADN, Protéines fongiques (génétique), Récepteurs des oestrogènes (génétique), Régions promotrices (génétique), Simplexvirus (enzymologie), Simplexvirus (génétique), Séquences d'acides nucléiques régulatrices, Thymidine (génétique), Transcription génétique, Transfection, Virus simien 40 (génétique), Éléments activateurs (génétique).
- MESH :
- enzymologie : Simplexvirus.
- génétique : ADN fongique, Globines, Protéines fongiques, Récepteurs des oestrogènes, Simplexvirus, Thymidine, Virus simien 40.
- métabolisme : Cellules HeLa.
- pharmacologie : Oestrogènes.
- ADN recombiné, Animaux, Facteurs de transcription, Humains, Lapins, Plasmides, Protéines de Saccharomyces cerevisiae, Protéines de liaison à l'ADN, Régions promotrices (génétique), Séquences d'acides nucléiques régulatrices, Transcription génétique, Transfection, Éléments activateurs (génétique).
English descriptors
- KwdEn :
- Animals, DNA, Fungal (genetics), DNA, Recombinant, DNA-Binding Proteins, Enhancer Elements, Genetic, Estrogens (pharmacology), Fungal Proteins (genetics), Globins (genetics), HeLa Cells (metabolism), Humans, Plasmids, Promoter Regions, Genetic, Rabbits, Receptors, Estrogen (genetics), Regulatory Sequences, Nucleic Acid, Saccharomyces cerevisiae Proteins, Simian virus 40 (genetics), Simplexvirus (enzymology), Simplexvirus (genetics), Thymidine (genetics), Transcription Factors, Transcription, Genetic, Transfection.
- MESH :
- chemical , genetics : DNA, Fungal, Fungal Proteins, Globins, Receptors, Estrogen, Thymidine.
- chemical , pharmacology : Estrogens.
- enzymology : Simplexvirus.
- genetics : Simian virus 40, Simplexvirus.
- metabolism : HeLa Cells.
- Teeft :
- 1fmer, Acidic, Acidic regions, Activator, Amino, Amino acid core, Amino acids, Animals, Binding domain, Chambon, Cotransfected, DNA, Recombinant, DNA-Binding Proteins, Densitometric scanning, Early promoter, Efficient transcription, Enhancer, Enhancer Elements, Genetic, Enhancer element, Enhancer elements, Estrogen, Estrogen receptor, Eukaryote, Eukaryotic, Experimental procedures, Gal4, Gal4 binding sites, Gal4 coding sequence, Gal4 expression vector, Gcn4, Gene, Giniger, Hela, Hela cells, Higher eukaryotes, Higher eukaryotic enhancers, Human estrogen receptor, Human hela cells, Humans, Kumar, Mammalian cells, Nuclease, Nuclease analysis, Plasmid, Plasmids, Polylinker, Promoter, Promoter Regions, Genetic, Promoter elements, Ptashne, Rabbits, Receptor, Reference gene, Reference gene pg1b, Reference plasmid, Regulatory Sequences, Nucleic Acid, Reporter gene, Reporter genes, Reporter plasmids, Saccharomyces cerevisiae Proteins, Schematic organization, Seal site, Struhl, Tata, Transcription, Transcription Factors, Transcription, Genetic, Transcriptional, Transcriptional activation, Transfection, Uase, Uaso, Unpublished data, Wasylyk, Yeast, Zenke.
Abstract
Abstract: The yeast trans-activator protein GAL4, when expressed in HeLa cells, stimulates transcription from several class B (II) eukaryotic promoters containing GAL4 binding sites either as the full UASG or as synthetic 17-mers. The characteristics of this activation are indistinguishable from those of the SV40 enhancer. Transcription was similarly stimulated from either complex promoter regions containing multiple upstream elements or from a simple promoter region composed of only a TATA box. Addition of a 17-mer GAL4 binding site to the SV40 enhancer resulted in a synergistic enhancement of transcription in the presence of GAL4. Furthermore, chimeras of the human estrogen receptor DNA binding domain and either GAL4 or GCN4 activating “acidic” regions can activate a promoter region controlled by an estrogen-responsive enhancer. Together, these data indicate that the molecular mechanisms responsible for transcriptional enhancement have been conserved from yeast to man.
Url:
DOI: 10.1016/0092-8674(88)90505-3
Affiliations:
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Le document en format XML
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<term>DNA, Fungal (genetics)</term>
<term>DNA, Recombinant</term>
<term>DNA-Binding Proteins</term>
<term>Enhancer Elements, Genetic</term>
<term>Estrogens (pharmacology)</term>
<term>Fungal Proteins (genetics)</term>
<term>Globins (genetics)</term>
<term>HeLa Cells (metabolism)</term>
<term>Humans</term>
<term>Plasmids</term>
<term>Promoter Regions, Genetic</term>
<term>Rabbits</term>
<term>Receptors, Estrogen (genetics)</term>
<term>Regulatory Sequences, Nucleic Acid</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Simian virus 40 (genetics)</term>
<term>Simplexvirus (enzymology)</term>
<term>Simplexvirus (genetics)</term>
<term>Thymidine (genetics)</term>
<term>Transcription Factors</term>
<term>Transcription, Genetic</term>
<term>Transfection</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN fongique (génétique)</term>
<term>ADN recombiné</term>
<term>Animaux</term>
<term>Cellules HeLa (métabolisme)</term>
<term>Facteurs de transcription</term>
<term>Globines (génétique)</term>
<term>Humains</term>
<term>Lapins</term>
<term>Oestrogènes (pharmacologie)</term>
<term>Plasmides</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines de liaison à l'ADN</term>
<term>Protéines fongiques (génétique)</term>
<term>Récepteurs des oestrogènes (génétique)</term>
<term>Régions promotrices (génétique)</term>
<term>Simplexvirus (enzymologie)</term>
<term>Simplexvirus (génétique)</term>
<term>Séquences d'acides nucléiques régulatrices</term>
<term>Thymidine (génétique)</term>
<term>Transcription génétique</term>
<term>Transfection</term>
<term>Virus simien 40 (génétique)</term>
<term>Éléments activateurs (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Fungal</term>
<term>Fungal Proteins</term>
<term>Globins</term>
<term>Receptors, Estrogen</term>
<term>Thymidine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Estrogens</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Simplexvirus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Simplexvirus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Simian virus 40</term>
<term>Simplexvirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN fongique</term>
<term>Globines</term>
<term>Protéines fongiques</term>
<term>Récepteurs des oestrogènes</term>
<term>Simplexvirus</term>
<term>Thymidine</term>
<term>Virus simien 40</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>HeLa Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules HeLa</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oestrogènes</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>1fmer</term>
<term>Acidic</term>
<term>Acidic regions</term>
<term>Activator</term>
<term>Amino</term>
<term>Amino acid core</term>
<term>Amino acids</term>
<term>Animals</term>
<term>Binding domain</term>
<term>Chambon</term>
<term>Cotransfected</term>
<term>DNA, Recombinant</term>
<term>DNA-Binding Proteins</term>
<term>Densitometric scanning</term>
<term>Early promoter</term>
<term>Efficient transcription</term>
<term>Enhancer</term>
<term>Enhancer Elements, Genetic</term>
<term>Enhancer element</term>
<term>Enhancer elements</term>
<term>Estrogen</term>
<term>Estrogen receptor</term>
<term>Eukaryote</term>
<term>Eukaryotic</term>
<term>Experimental procedures</term>
<term>Gal4</term>
<term>Gal4 binding sites</term>
<term>Gal4 coding sequence</term>
<term>Gal4 expression vector</term>
<term>Gcn4</term>
<term>Gene</term>
<term>Giniger</term>
<term>Hela</term>
<term>Hela cells</term>
<term>Higher eukaryotes</term>
<term>Higher eukaryotic enhancers</term>
<term>Human estrogen receptor</term>
<term>Human hela cells</term>
<term>Humans</term>
<term>Kumar</term>
<term>Mammalian cells</term>
<term>Nuclease</term>
<term>Nuclease analysis</term>
<term>Plasmid</term>
<term>Plasmids</term>
<term>Polylinker</term>
<term>Promoter</term>
<term>Promoter Regions, Genetic</term>
<term>Promoter elements</term>
<term>Ptashne</term>
<term>Rabbits</term>
<term>Receptor</term>
<term>Reference gene</term>
<term>Reference gene pg1b</term>
<term>Reference plasmid</term>
<term>Regulatory Sequences, Nucleic Acid</term>
<term>Reporter gene</term>
<term>Reporter genes</term>
<term>Reporter plasmids</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Schematic organization</term>
<term>Seal site</term>
<term>Struhl</term>
<term>Tata</term>
<term>Transcription</term>
<term>Transcription Factors</term>
<term>Transcription, Genetic</term>
<term>Transcriptional</term>
<term>Transcriptional activation</term>
<term>Transfection</term>
<term>Uase</term>
<term>Uaso</term>
<term>Unpublished data</term>
<term>Wasylyk</term>
<term>Yeast</term>
<term>Zenke</term>
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<term>Animaux</term>
<term>Facteurs de transcription</term>
<term>Humains</term>
<term>Lapins</term>
<term>Plasmides</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines de liaison à l'ADN</term>
<term>Régions promotrices (génétique)</term>
<term>Séquences d'acides nucléiques régulatrices</term>
<term>Transcription génétique</term>
<term>Transfection</term>
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<front><div type="abstract" xml:lang="en">Abstract: The yeast trans-activator protein GAL4, when expressed in HeLa cells, stimulates transcription from several class B (II) eukaryotic promoters containing GAL4 binding sites either as the full UASG or as synthetic 17-mers. The characteristics of this activation are indistinguishable from those of the SV40 enhancer. Transcription was similarly stimulated from either complex promoter regions containing multiple upstream elements or from a simple promoter region composed of only a TATA box. Addition of a 17-mer GAL4 binding site to the SV40 enhancer resulted in a synergistic enhancement of transcription in the presence of GAL4. Furthermore, chimeras of the human estrogen receptor DNA binding domain and either GAL4 or GCN4 activating “acidic” regions can activate a promoter region controlled by an estrogen-responsive enhancer. Together, these data indicate that the molecular mechanisms responsible for transcriptional enhancement have been conserved from yeast to man.</div>
</front>
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<affiliations><list><country><li>France</li>
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</country>
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<tree><noCountry><name sortKey="Webster, Nicholas" sort="Webster, Nicholas" uniqKey="Webster N" first="Nicholas" last="Webster">Nicholas Webster</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Jin, Jia Rui" sort="Jin, Jia Rui" uniqKey="Jin J" first="Jia Rui" last="Jin">Jia Rui Jin</name>
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<name sortKey="Chambon, Pierre" sort="Chambon, Pierre" uniqKey="Chambon P" first="Pierre" last="Chambon">Pierre Chambon</name>
<name sortKey="Green, Stephen" sort="Green, Stephen" uniqKey="Green S" first="Stephen" last="Green">Stephen Green</name>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Hollis, Melvyn" sort="Hollis, Melvyn" uniqKey="Hollis M" first="Melvyn" last="Hollis">Melvyn Hollis</name>
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