The effect of dopaminergic therapy on intraoperative microelectrode recordings for subthalamic deep brain stimulation under GA: can we operate on patients 'on medications'?
Identifieur interne : 000F92 ( Main/Exploration ); précédent : 000F91; suivant : 000F93The effect of dopaminergic therapy on intraoperative microelectrode recordings for subthalamic deep brain stimulation under GA: can we operate on patients 'on medications'?
Auteurs : Mohammed J. Asha [Royaume-Uni] ; Jamilla Kausar [Royaume-Uni] ; Hari Krovvidi [Royaume-Uni] ; Colin Shirley [Royaume-Uni] ; Anwen White [Royaume-Uni] ; Ramesh Chelvarajah [Royaume-Uni] ; James A. Hodson [Royaume-Uni] ; Hardev Pall [Royaume-Uni] ; Rosalind D. Mitchell [Royaume-Uni]Source :
- Acta neurochirurgica [ 0942-0940 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antiparkinsoniens, Lévodopa.
- Adulte d'âge moyen, Anesthésie générale, Femelle, Humains, Mâle, Noyau subthalamique, Stimulation cérébrale profonde, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- drug effects : Subthalamic Nucleus.
- Aged, Anesthesia, General, Contraindications, Deep Brain Stimulation, Female, Humans, Male, Middle Aged.
Abstract
Microelectrode recording (MER) plays an important role in target refinement in deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD). Traditionally, patients were operated on in the 'off-medication' state to allow intraoperative assessment of the patient response to direct STN stimulation. The development of intraoperative microelectrode recording (MER) has facilitated the introduction of general anaesthesia (GA). However, the routine withdrawal of dopaminergic medications has remained as standard practice. This retrospective review examines the effect of continuing these medications on intraoperative MER for subthalamic DBS insertion under GA and discusses the clinical implication of this approach.
DOI: 10.1007/s00701-015-2631-1
PubMed: 26602236
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Microelectrode recording (MER) plays an important role in target refinement in deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD). Traditionally, patients were operated on in the 'off-medication' state to allow intraoperative assessment of the patient response to direct STN stimulation. The development of intraoperative microelectrode recording (MER) has facilitated the introduction of general anaesthesia (GA). However, the routine withdrawal of dopaminergic medications has remained as standard practice. This retrospective review examines the effect of continuing these medications on intraoperative MER for subthalamic DBS insertion under GA and discusses the clinical implication of this approach.</div>
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