Identification of antibody epitopes within the CB-11 peptide of type II collagen. II. Computer modelling studies of peptides and the interpretation of epitope scanning results.
Identifieur interne : 004877 ( Main/Exploration ); précédent : 004876; suivant : 004878Identification of antibody epitopes within the CB-11 peptide of type II collagen. II. Computer modelling studies of peptides and the interpretation of epitope scanning results.
Auteurs : A. Brass [Royaume-Uni] ; J. Worthington ; Y. Chen ; K. MorganSource :
- Autoimmunity [ 0891-6934 ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Bovins, Bromure de cyanogène, Collagène (), Collagène (analyse), Données de séquences moléculaires, Fragments peptidiques (analyse), Modèles moléculaires, Polyarthrite rhumatoïde (), Polyarthrite rhumatoïde (immunologie), Simulation numérique, Sites de fixation des anticorps (immunologie), Séquence d'acides aminés, Épitopes (analyse).
- MESH :
- analyse : Collagène, Fragments peptidiques, Épitopes.
- immunologie : Polyarthrite rhumatoïde, Sites de fixation des anticorps.
- Animaux, Bovins, Bromure de cyanogène, Collagène, Données de séquences moléculaires, Modèles moléculaires, Polyarthrite rhumatoïde, Simulation numérique, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Arthritis, Rheumatoid (chemically induced), Arthritis, Rheumatoid (immunology), Binding Sites, Antibody (immunology), Cattle, Collagen (analysis), Collagen (chemistry), Computer Simulation, Cyanogen Bromide, Epitopes (analysis), Models, Molecular, Molecular Sequence Data, Peptide Fragments (analysis).
- MESH :
- chemical , analysis : Collagen, Epitopes, Peptide Fragments.
- chemically induced : Arthritis, Rheumatoid.
- chemical , chemistry : Collagen.
- immunology : Arthritis, Rheumatoid, Binding Sites, Antibody.
- Amino Acid Sequence, Animals, Cattle, Computer Simulation, Cyanogen Bromide, Models, Molecular, Molecular Sequence Data.
Abstract
Computer modelling techniques were used to investigate the structure of 8-mers from the CB-11 peptide of bovine type II collagen which were recognised by sera from rats which had previously been injected with bovine type II collage. It was discovered that all the hydrophobic peptides recognised by the rat sera were predicted to have collagenous-like secondary structures. The primary structure of the 8-mers which were recognised was also compared against the sequences in the OWL protein sequence database. The combined results of the computer modelling and sequence analysis suggested that the sequence Gly-Pro-Gly-Phe-Pro is a minimal B cell epitope of the CB-11 fragment of bovine type II collagen.
DOI: 10.3109/08916939109001891
PubMed: 1721847
Affiliations:
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Worthington</name></author><author><name sortKey="Chen, Y" sort="Chen, Y" uniqKey="Chen Y" first="Y" last="Chen">Y. Chen</name></author><author><name sortKey="Morgan, K" sort="Morgan, K" uniqKey="Morgan K" first="K" last="Morgan">K. 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II. Computer modelling studies of peptides and the interpretation of epitope scanning results.</title><author><name sortKey="Brass, A" sort="Brass, A" uniqKey="Brass A" first="A" last="Brass">A. Brass</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Manchester.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Worthington, J" sort="Worthington, J" uniqKey="Worthington J" first="J" last="Worthington">J. Worthington</name></author><author><name sortKey="Chen, Y" sort="Chen, Y" uniqKey="Chen Y" first="Y" last="Chen">Y. Chen</name></author><author><name sortKey="Morgan, K" sort="Morgan, K" uniqKey="Morgan K" first="K" last="Morgan">K. Morgan</name></author></analytic><series><title level="j">Autoimmunity</title><idno type="ISSN">0891-6934</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Arthritis, Rheumatoid (chemically induced)</term><term>Arthritis, Rheumatoid (immunology)</term><term>Binding Sites, Antibody (immunology)</term><term>Cattle</term><term>Collagen (analysis)</term><term>Collagen (chemistry)</term><term>Computer Simulation</term><term>Cyanogen Bromide</term><term>Epitopes (analysis)</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Peptide Fragments (analysis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Bovins</term><term>Bromure de cyanogène</term><term>Collagène ()</term><term>Collagène (analyse)</term><term>Données de séquences moléculaires</term><term>Fragments peptidiques (analyse)</term><term>Modèles moléculaires</term><term>Polyarthrite rhumatoïde ()</term><term>Polyarthrite rhumatoïde (immunologie)</term><term>Simulation numérique</term><term>Sites de fixation des anticorps (immunologie)</term><term>Séquence d'acides aminés</term><term>Épitopes (analyse)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Collagen</term><term>Epitopes</term><term>Peptide Fragments</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Collagène</term><term>Fragments peptidiques</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Collagen</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Polyarthrite rhumatoïde</term><term>Sites de fixation des anticorps</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Binding Sites, Antibody</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cattle</term><term>Computer Simulation</term><term>Cyanogen Bromide</term><term>Models, Molecular</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Bovins</term><term>Bromure de cyanogène</term><term>Collagène</term><term>Données de séquences moléculaires</term><term>Modèles moléculaires</term><term>Polyarthrite rhumatoïde</term><term>Simulation numérique</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Computer modelling techniques were used to investigate the structure of 8-mers from the CB-11 peptide of bovine type II collagen which were recognised by sera from rats which had previously been injected with bovine type II collage. It was discovered that all the hydrophobic peptides recognised by the rat sera were predicted to have collagenous-like secondary structures. The primary structure of the 8-mers which were recognised was also compared against the sequences in the OWL protein sequence database. The combined results of the computer modelling and sequence analysis suggested that the sequence Gly-Pro-Gly-Phe-Pro is a minimal B cell epitope of the CB-11 fragment of bovine type II collagen.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Manchester</li></region><settlement><li>Manchester</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><noCountry><name sortKey="Chen, Y" sort="Chen, Y" uniqKey="Chen Y" first="Y" last="Chen">Y. Chen</name><name sortKey="Morgan, K" sort="Morgan, K" uniqKey="Morgan K" first="K" last="Morgan">K. Morgan</name><name sortKey="Worthington, J" sort="Worthington, J" uniqKey="Worthington J" first="J" last="Worthington">J. Worthington</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Brass, A" sort="Brass, A" uniqKey="Brass A" first="A" last="Brass">A. Brass</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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