Identification of antibody epitopes within the CB-11 peptide of type II collagen. II. Computer modelling studies of peptides and the interpretation of epitope scanning results.
Identifieur interne : 004877 ( Main/Exploration ); précédent : 004876; suivant : 004878Identification of antibody epitopes within the CB-11 peptide of type II collagen. II. Computer modelling studies of peptides and the interpretation of epitope scanning results.
Auteurs : A. Brass [Royaume-Uni] ; J. Worthington ; Y. Chen ; K. MorganSource :
- Autoimmunity [ 0891-6934 ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Bovins, Bromure de cyanogène, Collagène (), Collagène (analyse), Données de séquences moléculaires, Fragments peptidiques (analyse), Modèles moléculaires, Polyarthrite rhumatoïde (), Polyarthrite rhumatoïde (immunologie), Simulation numérique, Sites de fixation des anticorps (immunologie), Séquence d'acides aminés, Épitopes (analyse).
- MESH :
- analyse : Collagène, Fragments peptidiques, Épitopes.
- immunologie : Polyarthrite rhumatoïde, Sites de fixation des anticorps.
- Animaux, Bovins, Bromure de cyanogène, Collagène, Données de séquences moléculaires, Modèles moléculaires, Polyarthrite rhumatoïde, Simulation numérique, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Arthritis, Rheumatoid (chemically induced), Arthritis, Rheumatoid (immunology), Binding Sites, Antibody (immunology), Cattle, Collagen (analysis), Collagen (chemistry), Computer Simulation, Cyanogen Bromide, Epitopes (analysis), Models, Molecular, Molecular Sequence Data, Peptide Fragments (analysis).
- MESH :
- chemical , analysis : Collagen, Epitopes, Peptide Fragments.
- chemically induced : Arthritis, Rheumatoid.
- chemical , chemistry : Collagen.
- immunology : Arthritis, Rheumatoid, Binding Sites, Antibody.
- Amino Acid Sequence, Animals, Cattle, Computer Simulation, Cyanogen Bromide, Models, Molecular, Molecular Sequence Data.
Abstract
Computer modelling techniques were used to investigate the structure of 8-mers from the CB-11 peptide of bovine type II collagen which were recognised by sera from rats which had previously been injected with bovine type II collage. It was discovered that all the hydrophobic peptides recognised by the rat sera were predicted to have collagenous-like secondary structures. The primary structure of the 8-mers which were recognised was also compared against the sequences in the OWL protein sequence database. The combined results of the computer modelling and sequence analysis suggested that the sequence Gly-Pro-Gly-Phe-Pro is a minimal B cell epitope of the CB-11 fragment of bovine type II collagen.
DOI: 10.3109/08916939109001891
PubMed: 1721847
Affiliations:
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Le document en format XML
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<term>Arthritis, Rheumatoid (immunology)</term>
<term>Binding Sites, Antibody (immunology)</term>
<term>Cattle</term>
<term>Collagen (analysis)</term>
<term>Collagen (chemistry)</term>
<term>Computer Simulation</term>
<term>Cyanogen Bromide</term>
<term>Epitopes (analysis)</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Peptide Fragments (analysis)</term>
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<term>Bovins</term>
<term>Bromure de cyanogène</term>
<term>Collagène ()</term>
<term>Collagène (analyse)</term>
<term>Données de séquences moléculaires</term>
<term>Fragments peptidiques (analyse)</term>
<term>Modèles moléculaires</term>
<term>Polyarthrite rhumatoïde ()</term>
<term>Polyarthrite rhumatoïde (immunologie)</term>
<term>Simulation numérique</term>
<term>Sites de fixation des anticorps (immunologie)</term>
<term>Séquence d'acides aminés</term>
<term>Épitopes (analyse)</term>
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<term>Epitopes</term>
<term>Peptide Fragments</term>
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<term>Fragments peptidiques</term>
<term>Épitopes</term>
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<term>Sites de fixation des anticorps</term>
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<term>Binding Sites, Antibody</term>
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<term>Computer Simulation</term>
<term>Cyanogen Bromide</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
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<term>Bromure de cyanogène</term>
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<term>Données de séquences moléculaires</term>
<term>Modèles moléculaires</term>
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<term>Simulation numérique</term>
<term>Séquence d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">Computer modelling techniques were used to investigate the structure of 8-mers from the CB-11 peptide of bovine type II collagen which were recognised by sera from rats which had previously been injected with bovine type II collage. It was discovered that all the hydrophobic peptides recognised by the rat sera were predicted to have collagenous-like secondary structures. The primary structure of the 8-mers which were recognised was also compared against the sequences in the OWL protein sequence database. The combined results of the computer modelling and sequence analysis suggested that the sequence Gly-Pro-Gly-Phe-Pro is a minimal B cell epitope of the CB-11 fragment of bovine type II collagen.</div>
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