Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways
Identifieur interne : 001690 ( Main/Exploration ); précédent : 001689; suivant : 001691Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways
Auteurs : Hin Chu ; Jie Zhou ; Bosco Ho-Yin Wong ; Cun Li ; Jasper Fuk-Woo Chan ; Zhong-Shan Cheng ; Dong Yang ; Dong Wang ; Andrew Chak-Yiu Lee ; Chuangen Li ; Man-Lung Yeung ; Jian-Piao Cai ; Ivy Hau-Yee Chan ; Wai-Kuen Ho ; Kelvin Kai-Wang To ; Bo-Jian Zheng ; Yanfeng Yao ; Chuan Qin ; Kwok-Yung Yuen [République populaire de Chine]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux, Apoptose (physiologie), Callithrix, Cellules cultivées, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Humains, Lymphocytes T (physiologie), Lymphocytes T (virologie), Rate (cytologie), Régulation de l'expression des gènes, Tonsille palatine (cytologie), Virus du SRAS (physiologie).
- MESH :
- cytologie : Rate, Tonsille palatine.
- génétique : Dipeptidyl peptidase 4.
- métabolisme : Dipeptidyl peptidase 4.
- physiologie : Apoptose, Coronavirus du syndrome respiratoire du Moyen-Orient, Lymphocytes T, Virus du SRAS.
- virologie : Lymphocytes T.
- Animaux, Anticorps antiviraux, Callithrix, Cellules cultivées, Humains, Régulation de l'expression des gènes.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral, Apoptosis (physiology), Callithrix, Cells, Cultured, Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Gene Expression Regulation, Humans, Middle East Respiratory Syndrome Coronavirus (physiology), Palatine Tonsil (cytology), SARS Virus (physiology), Spleen (cytology), T-Lymphocytes (physiology), T-Lymphocytes (virology).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4.
- chemical , metabolism : Dipeptidyl Peptidase 4.
- chemical : Antibodies, Viral.
- cytology : Palatine Tonsil, Spleen.
- physiology : Apoptosis, Middle East Respiratory Syndrome Coronavirus, SARS Virus, T-Lymphocytes.
- virology : T-Lymphocytes.
- Animals, Callithrix, Cells, Cultured, Gene Expression Regulation, Humans.
Abstract
Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV–infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3+ T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus.
Url:
DOI: 10.1093/infdis/jiv380
PubMed: 26203058
PubMed Central: 7107330
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways</title><author><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cheng, Zhong Shan" sort="Cheng, Zhong Shan" uniqKey="Cheng Z" first="Zhong-Shan" last="Cheng">Zhong-Shan Cheng</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew Chak Yiu" sort="Lee, Andrew Chak Yiu" uniqKey="Lee A" first="Andrew Chak-Yiu" last="Lee">Andrew Chak-Yiu Lee</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Chuangen" sort="Li, Chuangen" uniqKey="Li C" first="Chuangen" last="Li">Chuangen Li</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><affiliation><nlm:aff id="af5"><addr-line>Department of Surgery, University of Hong Kong</addr-line>,<institution>Hong Kong Special Administrative Region</institution></nlm:aff></affiliation></author><author><name sortKey="Ho, Wai Kuen" sort="Ho, Wai Kuen" uniqKey="Ho W" first="Wai-Kuen" last="Ho">Wai-Kuen Ho</name><affiliation><nlm:aff id="af5"><addr-line>Department of Surgery, University of Hong Kong</addr-line>,<institution>Hong Kong Special Administrative Region</institution></nlm:aff></affiliation></author><author><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><affiliation><nlm:aff id="af6"><addr-line>Institute of Laboratory Animal Sciences</addr-line>,<institution>Chinese Academy of Medical Sciences</institution></nlm:aff></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:aff id="af6"><addr-line>Institute of Laboratory Animal Sciences</addr-line>,<institution>Chinese Academy of Medical Sciences</institution></nlm:aff></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</addr-line>,<institution>Zhejiang University</institution>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country 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sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cheng, Zhong Shan" sort="Cheng, Zhong Shan" uniqKey="Cheng Z" first="Zhong-Shan" last="Cheng">Zhong-Shan Cheng</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew Chak Yiu" sort="Lee, Andrew Chak Yiu" uniqKey="Lee A" first="Andrew Chak-Yiu" last="Lee">Andrew Chak-Yiu Lee</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Chuangen" sort="Li, Chuangen" uniqKey="Li C" first="Chuangen" last="Li">Chuangen Li</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><affiliation><nlm:aff id="af5"><addr-line>Department of Surgery, University of Hong Kong</addr-line>,<institution>Hong Kong Special Administrative Region</institution></nlm:aff></affiliation></author><author><name sortKey="Ho, Wai Kuen" sort="Ho, Wai Kuen" uniqKey="Ho W" first="Wai-Kuen" last="Ho">Wai-Kuen Ho</name><affiliation><nlm:aff id="af5"><addr-line>Department of Surgery, University of Hong Kong</addr-line>,<institution>Hong Kong Special Administrative Region</institution></nlm:aff></affiliation></author><author><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><affiliation><nlm:aff id="af6"><addr-line>Institute of Laboratory Animal Sciences</addr-line>,<institution>Chinese Academy of Medical Sciences</institution></nlm:aff></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:aff id="af6"><addr-line>Institute of Laboratory Animal Sciences</addr-line>,<institution>Chinese Academy of Medical Sciences</institution></nlm:aff></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation><nlm:aff id="af1"><addr-line>State Key Laboratory of Emerging Infectious Diseases</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Microbiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Research Centre of Infection and Immunology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Carol Yu Centre for Infection</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</addr-line>,<institution>Zhejiang University</institution>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral</term><term>Apoptosis (physiology)</term><term>Callithrix</term><term>Cells, Cultured</term><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Gene Expression Regulation</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Palatine Tonsil (cytology)</term><term>SARS Virus (physiology)</term><term>Spleen (cytology)</term><term>T-Lymphocytes (physiology)</term><term>T-Lymphocytes (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Apoptose (physiologie)</term><term>Callithrix</term><term>Cellules cultivées</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Humains</term><term>Lymphocytes T (physiologie)</term><term>Lymphocytes T (virologie)</term><term>Rate (cytologie)</term><term>Régulation de l'expression des gènes</term><term>Tonsille palatine (cytologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rate</term><term>Tonsille palatine</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Palatine Tonsil</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apoptose</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Lymphocytes T</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apoptosis</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Callithrix</term><term>Cells, Cultured</term><term>Gene Expression Regulation</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Callithrix</term><term>Cellules cultivées</term><term>Humains</term><term>Régulation de l'expression des gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV–infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3<sup>+</sup> T cells. 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Chak-Yiu" last="Lee">Andrew Chak-Yiu Lee</name><name sortKey="Li, Chuangen" sort="Li, Chuangen" uniqKey="Li C" first="Chuangen" last="Li">Chuangen Li</name><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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