Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection
Identifieur interne : 001368 ( Main/Exploration ); précédent : 001367; suivant : 001369Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection
Auteurs : Ali H. Hajeer ; Hanan Balkhy ; Sameera Johani ; Mohammed Z. Yousef ; Yaseen ArabiSource :
- Annals of Thoracic Medicine [ 1817-1737 ] ; 2016.
Abstract
Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia.
We investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit.
A total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls.
Two HLA class II alleles were associated with the disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome.
Our results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be associated with susceptibility to MERS.
Url:
DOI: 10.4103/1817-1737.185756
PubMed: 27512511
PubMed Central: 4966224
Affiliations:
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<author><name sortKey="Balkhy, Hanan" sort="Balkhy, Hanan" uniqKey="Balkhy H" first="Hanan" last="Balkhy">Hanan Balkhy</name>
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<series><title level="j">Annals of Thoracic Medicine</title>
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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>BACKGROUND:</title>
<p>Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia.</p>
</sec>
<sec id="st2"><title>AIM:</title>
<p>We investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit.</p>
</sec>
<sec id="st3"><title>METHODS:</title>
<p>A total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls.</p>
</sec>
<sec id="st4"><title>RESULTS:</title>
<p>Two HLA class II alleles were associated with the disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome.</p>
</sec>
<sec id="st5"><title>CONCLUSIONS:</title>
<p>Our results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be associated with susceptibility to MERS.</p>
</sec>
</div>
</front>
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