Exploration
Accueil
Racine
Exploration
Accueil
Racine

Serveur d'exploration MERS

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates

Identifieur interne : 001C92 ( Main/Exploration ); précédent : 001C91; suivant : 001C93

Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates

Auteurs : Christian Selinger ; Jennifer Tisoncik-Go ; Vineet D. Menachery ; Sudhakar Agnihothram ; G Lynn Law ; Jean Chang ; Sara M. Kelly ; Pavel Sova ; Ralph S. Baric ; Michael G. Katze

Source :

RBID : PMC:4522970

Descripteurs français

English descriptors

Abstract

Background

The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging coronaviruses in humans. Clinical features of Middle East respiratory syndrome (MERS) include atypical pneumonia and progressive respiratory failure that is highly reminiscent of severe acute respiratory syndrome (SARS) caused by SARS-CoV. The host response is a key component of highly pathogenic respiratory virus infection. Here, we computationally analyzed gene expression changes in a human airway epithelial cell line infected with two genetically distinct MERS-CoV strains obtained from human patients, MERS-CoV SA 1 and MERS-CoV Eng 1.

Results

Using topological techniques, including persistence homology and filtered clustering, we performed a comparative transcriptional analysis of human Calu-3 cell host responses to the different MERS-CoV strains, with MERS-CoV Eng 1 inducing early kinetic changes, between 3 and 12 hours post infection, compared to MERS-CoV SA 1. Robust transcriptional changes distinguished the two MERS-CoV strains predominantly at the late time points. Combining statistical analysis of infection and cytokine-stimulated Calu-3 transcriptomics, we identified differential innate responses, including up-regulation of extracellular remodeling genes following MERS-CoV Eng 1 infection and differential pro-inflammatory responses.

Conclusions

Through our genomics-based approach, we found topological differences in the kinetics and magnitude of the host response to MERS-CoV SA 1 and MERS-CoV Eng 1, with differential expression of innate immune and pro-inflammatory responsive genes as a result of IFN, TNF and IL-1α signaling. Predicted activation for STAT3 mediating gene expression relevant for epithelial cell-to-cell adherens and junction signaling in MERS-CoV Eng 1 infection suggest that these transcriptional differences may be the result of amino acid differences in viral proteins known to modulate innate immunity during MERS-CoV infection.

Electronic supplementary material

The online version of this article (doi:10.1186/1471-2164-15-1161) contains supplementary material, which is available to authorized users.


Url:
DOI: 10.1186/1471-2164-15-1161
PubMed: 25534508
PubMed Central: 4522970


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates</title>
<author>
<name sortKey="Selinger, Christian" sort="Selinger, Christian" uniqKey="Selinger C" first="Christian" last="Selinger">Christian Selinger</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Tisoncik Go, Jennifer" sort="Tisoncik Go, Jennifer" uniqKey="Tisoncik Go J" first="Jennifer" last="Tisoncik-Go">Jennifer Tisoncik-Go</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name>
<affiliation>
<nlm:aff id="Aff2">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution>Department of Epidemiology,</institution>
<institution>University of North Carolina-Chapel Hill,</institution>
</institution-wrap>
Chapel Hill, North Carolina USA</nlm:aff>
<wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name>
<affiliation>
<nlm:aff id="Aff2">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution>Department of Epidemiology,</institution>
<institution>University of North Carolina-Chapel Hill,</institution>
</institution-wrap>
Chapel Hill, North Carolina USA</nlm:aff>
<wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Law, G Lynn" sort="Law, G Lynn" uniqKey="Law G" first="G Lynn" last="Law">G Lynn Law</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Chang, Jean" sort="Chang, Jean" uniqKey="Chang J" first="Jean" last="Chang">Jean Chang</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Kelly, Sara M" sort="Kelly, Sara M" uniqKey="Kelly S" first="Sara M" last="Kelly">Sara M. Kelly</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Sova, Pavel" sort="Sova, Pavel" uniqKey="Sova P" first="Pavel" last="Sova">Pavel Sova</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
<affiliation>
<nlm:aff id="Aff2">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution>Department of Epidemiology,</institution>
<institution>University of North Carolina-Chapel Hill,</institution>
</institution-wrap>
Chapel Hill, North Carolina USA</nlm:aff>
<wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">25534508</idno>
<idno type="pmc">4522970</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522970</idno>
<idno type="RBID">PMC:4522970</idno>
<idno type="doi">10.1186/1471-2164-15-1161</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000291</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000291</idno>
<idno type="wicri:Area/Pmc/Curation">000291</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000291</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001105</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001105</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:25534508</idno>
<idno type="wicri:Area/PubMed/Corpus">001748</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001748</idno>
<idno type="wicri:Area/PubMed/Curation">001748</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001748</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001947</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001947</idno>
<idno type="wicri:Area/Ncbi/Merge">001001</idno>
<idno type="wicri:Area/Ncbi/Curation">001001</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001001</idno>
<idno type="wicri:Area/Main/Merge">001D06</idno>
<idno type="wicri:Area/Main/Curation">001C92</idno>
<idno type="wicri:Area/Main/Exploration">001C92</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates</title>
<author>
<name sortKey="Selinger, Christian" sort="Selinger, Christian" uniqKey="Selinger C" first="Christian" last="Selinger">Christian Selinger</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Tisoncik Go, Jennifer" sort="Tisoncik Go, Jennifer" uniqKey="Tisoncik Go J" first="Jennifer" last="Tisoncik-Go">Jennifer Tisoncik-Go</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name>
<affiliation>
<nlm:aff id="Aff2">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution>Department of Epidemiology,</institution>
<institution>University of North Carolina-Chapel Hill,</institution>
</institution-wrap>
Chapel Hill, North Carolina USA</nlm:aff>
<wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name>
<affiliation>
<nlm:aff id="Aff2">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution>Department of Epidemiology,</institution>
<institution>University of North Carolina-Chapel Hill,</institution>
</institution-wrap>
Chapel Hill, North Carolina USA</nlm:aff>
<wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Law, G Lynn" sort="Law, G Lynn" uniqKey="Law G" first="G Lynn" last="Law">G Lynn Law</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Chang, Jean" sort="Chang, Jean" uniqKey="Chang J" first="Jean" last="Chang">Jean Chang</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Kelly, Sara M" sort="Kelly, Sara M" uniqKey="Kelly S" first="Sara M" last="Kelly">Sara M. Kelly</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Sova, Pavel" sort="Sova, Pavel" uniqKey="Sova P" first="Pavel" last="Sova">Pavel Sova</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
<affiliation>
<nlm:aff id="Aff2">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.10698.36</institution-id>
<institution-id institution-id-type="ISNI">0000000122483208</institution-id>
<institution>Department of Epidemiology,</institution>
<institution>University of North Carolina-Chapel Hill,</institution>
</institution-wrap>
Chapel Hill, North Carolina USA</nlm:aff>
<wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
<affiliation>
<nlm:aff id="Aff1">
<institution-wrap>
<institution-id institution-id-type="GRID">grid.34477.33</institution-id>
<institution-id institution-id-type="ISNI">0000000122986657</institution-id>
<institution>Department of Microbiology, School of Medicine,</institution>
<institution>University of Washington,</institution>
</institution-wrap>
Seattle, Washington USA,</nlm:aff>
<wicri:noCountry code="subfield">Washington USA</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series>
<title level="j">BMC Genomics</title>
<idno type="eISSN">1471-2164</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Cell Line</term>
<term>Cytokines (pharmacology)</term>
<term>Gene Expression Profiling</term>
<term>Genomics</term>
<term>Host-Pathogen Interactions (immunology)</term>
<term>Humans</term>
<term>Immunity, Innate (drug effects)</term>
<term>Inflammation (virology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>STAT3 Transcription Factor (metabolism)</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Analyse de profil d'expression de gènes</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Cytokines (pharmacologie)</term>
<term>Facteur de transcription STAT-3 (métabolisme)</term>
<term>Facteurs temps</term>
<term>Génomique</term>
<term>Humains</term>
<term>Immunité innée ()</term>
<term>Inflammation (virologie)</term>
<term>Interactions hôte-pathogène (immunologie)</term>
<term>Lignée cellulaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>STAT3 Transcription Factor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en">
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Immunity, Innate</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Interactions hôte-pathogène</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Host-Pathogen Interactions</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en">
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr">
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Facteur de transcription STAT-3</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr">
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr">
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Cell Line</term>
<term>Gene Expression Profiling</term>
<term>Genomics</term>
<term>Humans</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Analyse de profil d'expression de gènes</term>
<term>Facteurs temps</term>
<term>Génomique</term>
<term>Humains</term>
<term>Immunité innée</term>
<term>Lignée cellulaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background</title>
<p>The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging coronaviruses in humans. Clinical features of Middle East respiratory syndrome (MERS) include atypical pneumonia and progressive respiratory failure that is highly reminiscent of severe acute respiratory syndrome (SARS) caused by SARS-CoV. The host response is a key component of highly pathogenic respiratory virus infection. Here, we computationally analyzed gene expression changes in a human airway epithelial cell line infected with two genetically distinct MERS-CoV strains obtained from human patients, MERS-CoV SA 1 and MERS-CoV Eng 1.</p>
</sec>
<sec>
<title>Results</title>
<p>Using topological techniques, including persistence homology and filtered clustering, we performed a comparative transcriptional analysis of human Calu-3 cell host responses to the different MERS-CoV strains, with MERS-CoV Eng 1 inducing early kinetic changes, between 3 and 12 hours post infection, compared to MERS-CoV SA 1. Robust transcriptional changes distinguished the two MERS-CoV strains predominantly at the late time points. Combining statistical analysis of infection and cytokine-stimulated Calu-3 transcriptomics, we identified differential innate responses, including up-regulation of extracellular remodeling genes following MERS-CoV Eng 1 infection and differential pro-inflammatory responses.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>Through our genomics-based approach, we found topological differences in the kinetics and magnitude of the host response to MERS-CoV SA 1 and MERS-CoV Eng 1, with differential expression of innate immune and pro-inflammatory responsive genes as a result of IFN, TNF and IL-1α signaling. Predicted activation for STAT3 mediating gene expression relevant for epithelial cell-to-cell adherens and junction signaling in MERS-CoV Eng 1 infection suggest that these transcriptional differences may be the result of amino acid differences in viral proteins known to modulate innate immunity during MERS-CoV infection.</p>
</sec>
<sec>
<title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1471-2164-15-1161) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author>
<name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author>
<name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author>
<name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author>
<name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name>
</author>
<author>
<name sortKey="Chand, Ma" uniqKey="Chand M">MA Chand</name>
</author>
<author>
<name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name>
</author>
<author>
<name sortKey="Aarons, E" uniqKey="Aarons E">E Aarons</name>
</author>
<author>
<name sortKey="Tong, C" uniqKey="Tong C">C Tong</name>
</author>
<author>
<name sortKey="Langrish, C" uniqKey="Langrish C">C Langrish</name>
</author>
<author>
<name sortKey="Hoschler, K" uniqKey="Hoschler K">K Hoschler</name>
</author>
<author>
<name sortKey="Brown, K" uniqKey="Brown K">K Brown</name>
</author>
<author>
<name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name>
</author>
<author>
<name sortKey="Myers, R" uniqKey="Myers R">R Myers</name>
</author>
<author>
<name sortKey="Pebody, Rg" uniqKey="Pebody R">RG Pebody</name>
</author>
<author>
<name sortKey="Green, Hk" uniqKey="Green H">HK Green</name>
</author>
<author>
<name sortKey="Boddington, Nl" uniqKey="Boddington N">NL Boddington</name>
</author>
<author>
<name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name>
</author>
<author>
<name sortKey="Price, N" uniqKey="Price N">N Price</name>
</author>
<author>
<name sortKey="Newsholme, W" uniqKey="Newsholme W">W Newsholme</name>
</author>
<author>
<name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author>
<name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author>
<name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author>
<name sortKey="Mou, H" uniqKey="Mou H">H Mou</name>
</author>
<author>
<name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name>
</author>
<author>
<name sortKey="Dekkers, Dh" uniqKey="Dekkers D">DH Dekkers</name>
</author>
<author>
<name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name>
</author>
<author>
<name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name>
</author>
<author>
<name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
<author>
<name sortKey="Demmers, Ja" uniqKey="Demmers J">JA Demmers</name>
</author>
<author>
<name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name>
</author>
<author>
<name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author>
<name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name>
</author>
<author>
<name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author>
<name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name>
</author>
<author>
<name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author>
<name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name>
</author>
<author>
<name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author>
<name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author>
<name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author>
<name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name>
</author>
<author>
<name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name>
</author>
<author>
<name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author>
<name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author>
<name sortKey="Swanstrom, J" uniqKey="Swanstrom J">J Swanstrom</name>
</author>
<author>
<name sortKey="Bove, Pf" uniqKey="Bove P">PF Bove</name>
</author>
<author>
<name sortKey="Kim, Jd" uniqKey="Kim J">JD Kim</name>
</author>
<author>
<name sortKey="Grego, S" uniqKey="Grego S">S Grego</name>
</author>
<author>
<name sortKey="Randell, Sh" uniqKey="Randell S">SH Randell</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mielech, Am" uniqKey="Mielech A">AM Mielech</name>
</author>
<author>
<name sortKey="Kilianski, A" uniqKey="Kilianski A">A Kilianski</name>
</author>
<author>
<name sortKey="Baez Santos, Ym" uniqKey="Baez Santos Y">YM Baez-Santos</name>
</author>
<author>
<name sortKey="Mesecar, Ad" uniqKey="Mesecar A">AD Mesecar</name>
</author>
<author>
<name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Niemeyer, D" uniqKey="Niemeyer D">D Niemeyer</name>
</author>
<author>
<name sortKey="Zillinger, T" uniqKey="Zillinger T">T Zillinger</name>
</author>
<author>
<name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
<author>
<name sortKey="Zielecki, F" uniqKey="Zielecki F">F Zielecki</name>
</author>
<author>
<name sortKey="Horvath, G" uniqKey="Horvath G">G Horvath</name>
</author>
<author>
<name sortKey="Suliman, T" uniqKey="Suliman T">T Suliman</name>
</author>
<author>
<name sortKey="Barchet, W" uniqKey="Barchet W">W Barchet</name>
</author>
<author>
<name sortKey="Weber, F" uniqKey="Weber F">F Weber</name>
</author>
<author>
<name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author>
<name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Siu, Kl" uniqKey="Siu K">KL Siu</name>
</author>
<author>
<name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name>
</author>
<author>
<name sortKey="Kok, Kh" uniqKey="Kok K">KH Kok</name>
</author>
<author>
<name sortKey="Yuen, Ks" uniqKey="Yuen K">KS Yuen</name>
</author>
<author>
<name sortKey="Kew, C" uniqKey="Kew C">C Kew</name>
</author>
<author>
<name sortKey="Lui, Py" uniqKey="Lui P">PY Lui</name>
</author>
<author>
<name sortKey="Chan, Cp" uniqKey="Chan C">CP Chan</name>
</author>
<author>
<name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author>
<name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author>
<name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
<author>
<name sortKey="Jin, Dy" uniqKey="Jin D">DY Jin</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author>
<name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author>
<name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
<author>
<name sortKey="Chan, Ll" uniqKey="Chan L">LL Chan</name>
</author>
<author>
<name sortKey="Kuok, Di" uniqKey="Kuok D">DI Kuok</name>
</author>
<author>
<name sortKey="Fong, Jh" uniqKey="Fong J">JH Fong</name>
</author>
<author>
<name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author>
<name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author>
<name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
<author>
<name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
<author>
<name sortKey="Lau, Cc" uniqKey="Lau C">CC Lau</name>
</author>
<author>
<name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author>
<name sortKey="Li, Cp" uniqKey="Li C">CP Li</name>
</author>
<author>
<name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author>
<name sortKey="Jin, Dy" uniqKey="Jin D">DY Jin</name>
</author>
<author>
<name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name>
</author>
<author>
<name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author>
<name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kindler, E" uniqKey="Kindler E">E Kindler</name>
</author>
<author>
<name sortKey="Jonsdottir, Hr" uniqKey="Jonsdottir H">HR Jonsdottir</name>
</author>
<author>
<name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
<author>
<name sortKey="Hamming, Oj" uniqKey="Hamming O">OJ Hamming</name>
</author>
<author>
<name sortKey="Hartmann, R" uniqKey="Hartmann R">R Hartmann</name>
</author>
<author>
<name sortKey="Rodriguez, R" uniqKey="Rodriguez R">R Rodriguez</name>
</author>
<author>
<name sortKey="Geffers, R" uniqKey="Geffers R">R Geffers</name>
</author>
<author>
<name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author>
<name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author>
<name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name>
</author>
<author>
<name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name>
</author>
<author>
<name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Josset, L" uniqKey="Josset L">L Josset</name>
</author>
<author>
<name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author>
<name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author>
<name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
<author>
<name sortKey="Sova, P" uniqKey="Sova P">P Sova</name>
</author>
<author>
<name sortKey="Carter, Vs" uniqKey="Carter V">VS Carter</name>
</author>
<author>
<name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author>
<name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author>
<name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Faure, E" uniqKey="Faure E">E Faure</name>
</author>
<author>
<name sortKey="Poissy, J" uniqKey="Poissy J">J Poissy</name>
</author>
<author>
<name sortKey="Goffard, A" uniqKey="Goffard A">A Goffard</name>
</author>
<author>
<name sortKey="Fournier, C" uniqKey="Fournier C">C Fournier</name>
</author>
<author>
<name sortKey="Kipnis, E" uniqKey="Kipnis E">E Kipnis</name>
</author>
<author>
<name sortKey="Titecat, M" uniqKey="Titecat M">M Titecat</name>
</author>
<author>
<name sortKey="Bortolotti, P" uniqKey="Bortolotti P">P Bortolotti</name>
</author>
<author>
<name sortKey="Martinez, L" uniqKey="Martinez L">L Martinez</name>
</author>
<author>
<name sortKey="Dubucquoi, S" uniqKey="Dubucquoi S">S Dubucquoi</name>
</author>
<author>
<name sortKey="Dessein, R" uniqKey="Dessein R">R Dessein</name>
</author>
<author>
<name sortKey="Gosset, P" uniqKey="Gosset P">P Gosset</name>
</author>
<author>
<name sortKey="Mathieu, D" uniqKey="Mathieu D">D Mathieu</name>
</author>
<author>
<name sortKey="Guery, B" uniqKey="Guery B">B Guery</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name>
</author>
<author>
<name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name>
</author>
<author>
<name sortKey="Kellam, P" uniqKey="Kellam P">P Kellam</name>
</author>
<author>
<name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name>
</author>
<author>
<name sortKey="Makhdoom, Hq" uniqKey="Makhdoom H">HQ Makhdoom</name>
</author>
<author>
<name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
<author>
<name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name>
</author>
<author>
<name sortKey="Alhakeem, Rf" uniqKey="Alhakeem R">RF Alhakeem</name>
</author>
<author>
<name sortKey="Madani, H" uniqKey="Madani H">H Madani</name>
</author>
<author>
<name sortKey="Alrabiah, Fa" uniqKey="Alrabiah F">FA Alrabiah</name>
</author>
<author>
<name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S Al Hajjar</name>
</author>
<author>
<name sortKey="Al Nassir, Wn" uniqKey="Al Nassir W">WN Al-nassir</name>
</author>
<author>
<name sortKey="Albarrak, A" uniqKey="Albarrak A">A Albarrak</name>
</author>
<author>
<name sortKey="Flemban, H" uniqKey="Flemban H">H Flemban</name>
</author>
<author>
<name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name>
</author>
<author>
<name sortKey="Alsubaie, S" uniqKey="Alsubaie S">S Alsubaie</name>
</author>
<author>
<name sortKey="Palser, Al" uniqKey="Palser A">AL Palser</name>
</author>
<author>
<name sortKey="Gall, A" uniqKey="Gall A">A Gall</name>
</author>
<author>
<name sortKey="Bashford Rogers, R" uniqKey="Bashford Rogers R">R Bashford-Rogers</name>
</author>
<author>
<name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
<author>
<name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name>
</author>
<author>
<name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
<author>
<name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name>
</author>
<author>
<name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author>
<name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name>
</author>
<author>
<name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author>
<name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author>
<name sortKey="Scobey, Td" uniqKey="Scobey T">TD Scobey</name>
</author>
<author>
<name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author>
<name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name>
</author>
<author>
<name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Edelsbrunner, H" uniqKey="Edelsbrunner H">H Edelsbrunner</name>
</author>
<author>
<name sortKey="Letscher, D" uniqKey="Letscher D">D Letscher</name>
</author>
<author>
<name sortKey="Zomorodian, A" uniqKey="Zomorodian A">A Zomorodian</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Edelsbrunner, H" uniqKey="Edelsbrunner H">H Edelsbrunner</name>
</author>
<author>
<name sortKey="Harer, Jl" uniqKey="Harer J">JL Harer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Singh, G" uniqKey="Singh G">G Singh</name>
</author>
<author>
<name sortKey="Memoli, F" uniqKey="Memoli F">F Mémoli</name>
</author>
<author>
<name sortKey="Carlsson, G" uniqKey="Carlsson G">G Carlsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author>
<name sortKey="Tilton, Sc" uniqKey="Tilton S">SC Tilton</name>
</author>
<author>
<name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author>
<name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author>
<name sortKey="Schafer, A" uniqKey="Schafer A">A Schafer</name>
</author>
<author>
<name sortKey="Matzke, Mm" uniqKey="Matzke M">MM Matzke</name>
</author>
<author>
<name sortKey="Webb Robertson, Bj" uniqKey="Webb Robertson B">BJ Webb-Robertson</name>
</author>
<author>
<name sortKey="Chang, J" uniqKey="Chang J">J Chang</name>
</author>
<author>
<name sortKey="Luna, Ml" uniqKey="Luna M">ML Luna</name>
</author>
<author>
<name sortKey="Long, Ce" uniqKey="Long C">CE Long</name>
</author>
<author>
<name sortKey="Shukla, Ak" uniqKey="Shukla A">AK Shukla</name>
</author>
<author>
<name sortKey="Bankhead, Ar" uniqKey="Bankhead A">AR Bankhead</name>
</author>
<author>
<name sortKey="Burkett, Se" uniqKey="Burkett S">SE Burkett</name>
</author>
<author>
<name sortKey="Zornetzer, G" uniqKey="Zornetzer G">G Zornetzer</name>
</author>
<author>
<name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name>
</author>
<author>
<name sortKey="Metz, To" uniqKey="Metz T">TO Metz</name>
</author>
<author>
<name sortKey="Pickles, R" uniqKey="Pickles R">R Pickles</name>
</author>
<author>
<name sortKey="Mcweeney, S" uniqKey="Mcweeney S">S McWeeney</name>
</author>
<author>
<name sortKey="Smith, Rd" uniqKey="Smith R">RD Smith</name>
</author>
<author>
<name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author>
<name sortKey="Waters, Km" uniqKey="Waters K">KM Waters</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Totura, Al" uniqKey="Totura A">AL Totura</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tao, X" uniqKey="Tao X">X Tao</name>
</author>
<author>
<name sortKey="Hill, Te" uniqKey="Hill T">TE Hill</name>
</author>
<author>
<name sortKey="Morimoto, C" uniqKey="Morimoto C">C Morimoto</name>
</author>
<author>
<name sortKey="Peters, Cj" uniqKey="Peters C">CJ Peters</name>
</author>
<author>
<name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
<author>
<name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chen, L C" uniqKey="Chen L">L-C Chen</name>
</author>
<author>
<name sortKey="Chen, C C" uniqKey="Chen C">C-C Chen</name>
</author>
<author>
<name sortKey="Liang, Y" uniqKey="Liang Y">Y Liang</name>
</author>
<author>
<name sortKey="Tsang, N M" uniqKey="Tsang N">N-M Tsang</name>
</author>
<author>
<name sortKey="Chang, Y S" uniqKey="Chang Y">Y-S Chang</name>
</author>
<author>
<name sortKey="Hsueh, C" uniqKey="Hsueh C">C Hsueh</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Platanias, Lc" uniqKey="Platanias L">LC Platanias</name>
</author>
<author>
<name sortKey="Fish, En" uniqKey="Fish E">EN Fish</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Park, H" uniqKey="Park H">H Park</name>
</author>
<author>
<name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
<author>
<name sortKey="Yang, Xo" uniqKey="Yang X">XO Yang</name>
</author>
<author>
<name sortKey="Chang, Sh" uniqKey="Chang S">SH Chang</name>
</author>
<author>
<name sortKey="Nurieva, R" uniqKey="Nurieva R">R Nurieva</name>
</author>
<author>
<name sortKey="Wang, Yh" uniqKey="Wang Y">YH Wang</name>
</author>
<author>
<name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author>
<name sortKey="Hood, L" uniqKey="Hood L">L Hood</name>
</author>
<author>
<name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name>
</author>
<author>
<name sortKey="Tian, Q" uniqKey="Tian Q">Q Tian</name>
</author>
<author>
<name sortKey="Dong, C" uniqKey="Dong C">C Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Malicet, C" uniqKey="Malicet C">C Malicet</name>
</author>
<author>
<name sortKey="Giroux, V" uniqKey="Giroux V">V Giroux</name>
</author>
<author>
<name sortKey="Vasseur, S" uniqKey="Vasseur S">S Vasseur</name>
</author>
<author>
<name sortKey="Dagorn, Jc" uniqKey="Dagorn J">JC Dagorn</name>
</author>
<author>
<name sortKey="Neira, Jl" uniqKey="Neira J">JL Neira</name>
</author>
<author>
<name sortKey="Iovanna, Jl" uniqKey="Iovanna J">JL Iovanna</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jiang, Yf" uniqKey="Jiang Y">YF Jiang</name>
</author>
<author>
<name sortKey="Vaccaro, Mi" uniqKey="Vaccaro M">MI Vaccaro</name>
</author>
<author>
<name sortKey="Fiedler, F" uniqKey="Fiedler F">F Fiedler</name>
</author>
<author>
<name sortKey="Calvo, El" uniqKey="Calvo E">EL Calvo</name>
</author>
<author>
<name sortKey="Iovanna, Jl" uniqKey="Iovanna J">JL Iovanna</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Vasseur, S" uniqKey="Vasseur S">S Vasseur</name>
</author>
<author>
<name sortKey="Hoffmeister, A" uniqKey="Hoffmeister A">A Hoffmeister</name>
</author>
<author>
<name sortKey="Garcia Montero, A" uniqKey="Garcia Montero A">A Garcia-Montero</name>
</author>
<author>
<name sortKey="Mallo, Gv" uniqKey="Mallo G">GV Mallo</name>
</author>
<author>
<name sortKey="Feil, R" uniqKey="Feil R">R Feil</name>
</author>
<author>
<name sortKey="Kuhbandner, S" uniqKey="Kuhbandner S">S Kuhbandner</name>
</author>
<author>
<name sortKey="Dagorn, Jc" uniqKey="Dagorn J">JC Dagorn</name>
</author>
<author>
<name sortKey="Iovanna, Jl" uniqKey="Iovanna J">JL Iovanna</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kreisel, D" uniqKey="Kreisel D">D Kreisel</name>
</author>
<author>
<name sortKey="Sugimoto, S" uniqKey="Sugimoto S">S Sugimoto</name>
</author>
<author>
<name sortKey="Tietjens, J" uniqKey="Tietjens J">J Tietjens</name>
</author>
<author>
<name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name>
</author>
<author>
<name sortKey="Yamamoto, S" uniqKey="Yamamoto S">S Yamamoto</name>
</author>
<author>
<name sortKey="Krupnick, As" uniqKey="Krupnick A">AS Krupnick</name>
</author>
<author>
<name sortKey="Carmody, Rj" uniqKey="Carmody R">RJ Carmody</name>
</author>
<author>
<name sortKey="Gelman, Ae" uniqKey="Gelman A">AE Gelman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Deng, X" uniqKey="Deng X">X Deng</name>
</author>
<author>
<name sortKey="Xu, M" uniqKey="Xu M">M Xu</name>
</author>
<author>
<name sortKey="Yuan, C" uniqKey="Yuan C">C Yuan</name>
</author>
<author>
<name sortKey="Yin, L" uniqKey="Yin L">L Yin</name>
</author>
<author>
<name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author>
<name sortKey="Zhou, X" uniqKey="Zhou X">X Zhou</name>
</author>
<author>
<name sortKey="Li, G" uniqKey="Li G">G Li</name>
</author>
<author>
<name sortKey="Fu, Y" uniqKey="Fu Y">Y Fu</name>
</author>
<author>
<name sortKey="Feghali Bostwick, Ca" uniqKey="Feghali Bostwick C">CA Feghali-Bostwick</name>
</author>
<author>
<name sortKey="Pang, L" uniqKey="Pang L">L Pang</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Held, Ks" uniqKey="Held K">KS Held</name>
</author>
<author>
<name sortKey="Chen, Bp" uniqKey="Chen B">BP Chen</name>
</author>
<author>
<name sortKey="Kuziel, Wa" uniqKey="Kuziel W">WA Kuziel</name>
</author>
<author>
<name sortKey="Rollins, Bj" uniqKey="Rollins B">BJ Rollins</name>
</author>
<author>
<name sortKey="Lane, Te" uniqKey="Lane T">TE Lane</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wathelet, Mg" uniqKey="Wathelet M">MG Wathelet</name>
</author>
<author>
<name sortKey="Orr, M" uniqKey="Orr M">M Orr</name>
</author>
<author>
<name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Seto, T" uniqKey="Seto T">T Seto</name>
</author>
<author>
<name sortKey="Yoshitake, M" uniqKey="Yoshitake M">M Yoshitake</name>
</author>
<author>
<name sortKey="Ogasawara, T" uniqKey="Ogasawara T">T Ogasawara</name>
</author>
<author>
<name sortKey="Ikari, J" uniqKey="Ikari J">J Ikari</name>
</author>
<author>
<name sortKey="Sakamoto, A" uniqKey="Sakamoto A">A Sakamoto</name>
</author>
<author>
<name sortKey="Hatano, M" uniqKey="Hatano M">M Hatano</name>
</author>
<author>
<name sortKey="Hirata, H" uniqKey="Hirata H">H Hirata</name>
</author>
<author>
<name sortKey="Fukuda, T" uniqKey="Fukuda T">T Fukuda</name>
</author>
<author>
<name sortKey="Kuriyama, T" uniqKey="Kuriyama T">T Kuriyama</name>
</author>
<author>
<name sortKey="Tatsumi, K" uniqKey="Tatsumi K">K Tatsumi</name>
</author>
<author>
<name sortKey="Tokuhisa, T" uniqKey="Tokuhisa T">T Tokuhisa</name>
</author>
<author>
<name sortKey="Arima, M" uniqKey="Arima M">M Arima</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mizutani, T" uniqKey="Mizutani T">T Mizutani</name>
</author>
<author>
<name sortKey="Fukushi, S" uniqKey="Fukushi S">S Fukushi</name>
</author>
<author>
<name sortKey="Murakami, M" uniqKey="Murakami M">M Murakami</name>
</author>
<author>
<name sortKey="Hirano, T" uniqKey="Hirano T">T Hirano</name>
</author>
<author>
<name sortKey="Saijo, M" uniqKey="Saijo M">M Saijo</name>
</author>
<author>
<name sortKey="Kurane, I" uniqKey="Kurane I">I Kurane</name>
</author>
<author>
<name sortKey="Morikawa, S" uniqKey="Morikawa S">S Morikawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author>
<name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author>
<name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name>
</author>
<author>
<name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name>
</author>
<author>
<name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name>
</author>
<author>
<name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name>
</author>
<author>
<name sortKey="Brining, D" uniqKey="Brining D">D Brining</name>
</author>
<author>
<name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name>
</author>
<author>
<name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name>
</author>
<author>
<name sortKey="Baseler, L" uniqKey="Baseler L">L Baseler</name>
</author>
<author>
<name sortKey="Benecke, Ag" uniqKey="Benecke A">AG Benecke</name>
</author>
<author>
<name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author>
<name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author>
<name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author>
<name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author>
<name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name>
</author>
<author>
<name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name>
</author>
<author>
<name sortKey="Okumura, A" uniqKey="Okumura A">A Okumura</name>
</author>
<author>
<name sortKey="Peng, X" uniqKey="Peng X">X Peng</name>
</author>
<author>
<name sortKey="Thomas, Mj" uniqKey="Thomas M">MJ Thomas</name>
</author>
<author>
<name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
<author>
<name sortKey="Haddock, E" uniqKey="Haddock E">E Haddock</name>
</author>
<author>
<name sortKey="Nagy, L" uniqKey="Nagy L">L Nagy</name>
</author>
<author>
<name sortKey="Lacasse, R" uniqKey="Lacasse R">R LaCasse</name>
</author>
<author>
<name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
</author>
<author>
<name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name>
</author>
<author>
<name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name>
</author>
<author>
<name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name>
</author>
<author>
<name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author>
<name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name>
</author>
<author>
<name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author>
<name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author>
<name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
<author>
<name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name>
</author>
<author>
<name sortKey="Fett, C" uniqKey="Fett C">C Fett</name>
</author>
<author>
<name sortKey="Gale, Mj" uniqKey="Gale M">MJ Gale</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author>
<name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name>
</author>
<author>
<name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name>
</author>
<author>
<name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name>
</author>
<author>
<name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
<author>
<name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author>
<name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name>
</author>
<author>
<name sortKey="Huynh, J" uniqKey="Huynh J">J Huynh</name>
</author>
<author>
<name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author>
<name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author>
<name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name>
</author>
<author>
<name sortKey="Becker, Mm" uniqKey="Becker M">MM Becker</name>
</author>
<author>
<name sortKey="Tomar, S" uniqKey="Tomar S">S Tomar</name>
</author>
<author>
<name sortKey="Scobey, Td" uniqKey="Scobey T">TD Scobey</name>
</author>
<author>
<name sortKey="Osswald, Hl" uniqKey="Osswald H">HL Osswald</name>
</author>
<author>
<name sortKey="Whitmore, A" uniqKey="Whitmore A">A Whitmore</name>
</author>
<author>
<name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name>
</author>
<author>
<name sortKey="Ghosh, Ak" uniqKey="Ghosh A">AK Ghosh</name>
</author>
<author>
<name sortKey="Mesecar, A" uniqKey="Mesecar A">A Mesecar</name>
</author>
<author>
<name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name>
</author>
<author>
<name sortKey="Heise, M" uniqKey="Heise M">M Heise</name>
</author>
<author>
<name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Law, Gl" uniqKey="Law G">GL Law</name>
</author>
<author>
<name sortKey="Tisoncik Go, J" uniqKey="Tisoncik Go J">J Tisoncik-Go</name>
</author>
<author>
<name sortKey="Korth, Mj" uniqKey="Korth M">MJ Korth</name>
</author>
<author>
<name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author>
<name sortKey="Eisfeld, Aj" uniqKey="Eisfeld A">AJ Eisfeld</name>
</author>
<author>
<name sortKey="Schafer, A" uniqKey="Schafer A">A Schafer</name>
</author>
<author>
<name sortKey="Josset, L" uniqKey="Josset L">L Josset</name>
</author>
<author>
<name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
<author>
<name sortKey="Proll, S" uniqKey="Proll S">S Proll</name>
</author>
<author>
<name sortKey="Fan, S" uniqKey="Fan S">S Fan</name>
</author>
<author>
<name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author>
<name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name>
</author>
<author>
<name sortKey="Tilton, Sc" uniqKey="Tilton S">SC Tilton</name>
</author>
<author>
<name sortKey="Chang, J" uniqKey="Chang J">J Chang</name>
</author>
<author>
<name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author>
<name sortKey="Long, C" uniqKey="Long C">C Long</name>
</author>
<author>
<name sortKey="Green, R" uniqKey="Green R">R Green</name>
</author>
<author>
<name sortKey="Williams, Cm" uniqKey="Williams C">CM Williams</name>
</author>
<author>
<name sortKey="Weiss, J" uniqKey="Weiss J">J Weiss</name>
</author>
<author>
<name sortKey="Matzke, Mm" uniqKey="Matzke M">MM Matzke</name>
</author>
<author>
<name sortKey="Webb Robertson, B J" uniqKey="Webb Robertson B">B-J Webb-Robertson</name>
</author>
<author>
<name sortKey="Schepmoes, Aa" uniqKey="Schepmoes A">AA Schepmoes</name>
</author>
<author>
<name sortKey="Shukla, Ak" uniqKey="Shukla A">AK Shukla</name>
</author>
<author>
<name sortKey="Metz, To" uniqKey="Metz T">TO Metz</name>
</author>
<author>
<name sortKey="Smith, Rd" uniqKey="Smith R">RD Smith</name>
</author>
<author>
<name sortKey="Waters, Km" uniqKey="Waters K">KM Waters</name>
</author>
<author>
<name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author>
<name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
<author>
<name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Johnson, We" uniqKey="Johnson W">WE Johnson</name>
</author>
<author>
<name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author>
<name sortKey="Rabinovic, A" uniqKey="Rabinovic A">A Rabinovic</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tausz, A" uniqKey="Tausz A">A Tausz</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Carlsson, G" uniqKey="Carlsson G">G Carlsson</name>
</author>
<author>
<name sortKey="Zomorodian, A" uniqKey="Zomorodian A">A Zomorodian</name>
</author>
<author>
<name sortKey="Collins, A" uniqKey="Collins A">A Collins</name>
</author>
<author>
<name sortKey="Guibas, L" uniqKey="Guibas L">L Guibas</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kruskal, Jb" uniqKey="Kruskal J">JB Kruskal</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Smyth, G" uniqKey="Smyth G">G Smyth</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Rozen, S" uniqKey="Rozen S">S Rozen</name>
</author>
<author>
<name sortKey="Skaletsky, H" uniqKey="Skaletsky H">H Skaletsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name>
</author>
<author>
<name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chen, Ey" uniqKey="Chen E">EY Chen</name>
</author>
<author>
<name sortKey="Tan, Cm" uniqKey="Tan C">CM Tan</name>
</author>
<author>
<name sortKey="Kou, Y" uniqKey="Kou Y">Y Kou</name>
</author>
<author>
<name sortKey="Duan, Q" uniqKey="Duan Q">Q Duan</name>
</author>
<author>
<name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author>
<name sortKey="Meirelles, Gv" uniqKey="Meirelles G">GV Meirelles</name>
</author>
<author>
<name sortKey="Clark, Nr" uniqKey="Clark N">NR Clark</name>
</author>
<author>
<name sortKey="Ma Ayan, A" uniqKey="Ma Ayan A">A Ma'ayan</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zambelli, F" uniqKey="Zambelli F">F Zambelli</name>
</author>
<author>
<name sortKey="Pesole, G" uniqKey="Pesole G">G Pesole</name>
</author>
<author>
<name sortKey="Pavesi, G" uniqKey="Pavesi G">G Pavesi</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations>
<list></list>
<tree>
<noCountry>
<name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
<name sortKey="Chang, Jean" sort="Chang, Jean" uniqKey="Chang J" first="Jean" last="Chang">Jean Chang</name>
<name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name>
<name sortKey="Kelly, Sara M" sort="Kelly, Sara M" uniqKey="Kelly S" first="Sara M" last="Kelly">Sara M. Kelly</name>
<name sortKey="Law, G Lynn" sort="Law, G Lynn" uniqKey="Law G" first="G Lynn" last="Law">G Lynn Law</name>
<name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name>
<name sortKey="Selinger, Christian" sort="Selinger, Christian" uniqKey="Selinger C" first="Christian" last="Selinger">Christian Selinger</name>
<name sortKey="Sova, Pavel" sort="Sova, Pavel" uniqKey="Sova P" first="Pavel" last="Sova">Pavel Sova</name>
<name sortKey="Tisoncik Go, Jennifer" sort="Tisoncik Go, Jennifer" uniqKey="Tisoncik Go J" first="Jennifer" last="Tisoncik-Go">Jennifer Tisoncik-Go</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C92 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001C92 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4522970
   |texte=   Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25534508" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1
Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021