Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors
Identifieur interne : 002043 ( Main/Exploration ); précédent : 002042; suivant : 002044Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors
Auteurs : Andy Kilianski ; Susan C. BakerSource :
- Antiviral Research [ 0166-3542 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- isolement et purification : Antiviraux.
- pharmacologie : Antiviraux.
- Animaux, Coronavirus, Humains, Lignée cellulaire, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- MESH :
- chemical , isolation & purification : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents.
- drug effects : Coronavirus.
- methods : Drug Evaluation, Preclinical.
- Animals, Cell Line, Humans.
Abstract
Coronavirus entry, proteolytic processing and RNA synthesis enzymes are attractive targets for antivirals. Cell-based screens have been used to identify and evaluate antivirals against SARS-CoV and MERS-CoV. New approaches are available to characterize pan-coronavirus inhibitors against CoV proteases. Antivirals against SARS-CoV may have efficacy against MERS-CoV and other emerging coronaviruses.
Url:
DOI: 10.1016/j.antiviral.2013.11.004
PubMed: 24269477
PubMed Central: 3931262
Affiliations:
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Le document en format XML
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Baker</name></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Cell Line</term><term>Coronavirus (drug effects)</term><term>Drug Evaluation, Preclinical (methods)</term><term>Humans</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Coronavirus ()</term><term>Humains</term><term>Lignée cellulaire</term><term>Évaluation préclinique de médicament ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Evaluation, Preclinical</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus</term><term>Humains</term><term>Lignée cellulaire</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0140">Coronavirus entry, proteolytic processing and RNA synthesis enzymes are attractive targets for antivirals.</p></list-item><list-item id="o0010"><label>•</label><p id="p0145">Cell-based screens have been used to identify and evaluate antivirals against SARS-CoV and MERS-CoV.</p></list-item><list-item id="o0015"><label>•</label><p id="p0150">New approaches are available to characterize pan-coronavirus inhibitors against CoV proteases.</p></list-item><list-item id="o0020"><label>•</label><p id="p0155">Antivirals against SARS-CoV may have efficacy against MERS-CoV and other emerging coronaviruses.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adedeji, A O" uniqKey="Adedeji A">A.O. 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Gao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name><name sortKey="Kilianski, Andy" sort="Kilianski, Andy" uniqKey="Kilianski A" first="Andy" last="Kilianski">Andy Kilianski</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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