MersV1, Main, Exploration, bibRecord, 004910

Pre-mRNA splicing as a target for antisense oligonucleotides

Identifieur interne : 004910 ( Main/Exploration ); précédent : 004909; suivant : 004911

Pre-mRNA splicing as a target for antisense oligonucleotides

Auteurs : Ryszard Kole [États-Unis] ; Ram R. Shukla [États-Unis] ; Saghir Akhtar [États-Unis]

Source :

Advanced Drug Delivery Reviews [ 0169-409X ] ; 1991.

RBID : ISTEX:182C0B5F1611BB8E2B8203EAC9B4DE94CC553472

English descriptors

Teeft :
- Acad, Antisense, Antisense oligonucleotides, Antiviral, Antiviral activity, Biol, Branch point, Branch point sequence, Branch point sequences, Cell membrane, Chapel hill, Cleavage, Cultured cells, Exon, Exon sequences, First step, Form duplexes, Gene expression, Herpes simplex virus type, Human immunodeficiency virus, Immunodeficiency, Intron, Intron sequences, Kole, Large number, Mrna, Natl, Nucleic acids, Nucleotide, Oligonucleotide, Oligonucleotides, Oligonucleotides antisense, Phosphorothioate, Proc, Replication, Ribonucleoprotein, Ribonucleoprotein particle, Ribonucleoprotein particles, Rnase, Snrna, Snrnp, Snrnps, Splice, Splice site, Splice sites, Spliceosome, Viral, Zamecnik.

Abstract

Abstract: Splicing is one of the major post-transcriptional modifications a eukaryotic mRNA precursor (pre-mRNA) has to undergo to yield the mature mRNA. During pre-mRNA splicing the non-coding sequences (introns) of the precursor are removed and coding sequences (exons) are joined. This process takes place within a complex called a spliceosome and requires the presence of a number of splicing factors such as small nuclear ribonucleoprotein particles (snRNPs). Oligonucleotides containing sequences complementary (antisense) to unique sequences within the pre-mRNA can be used to modify splicing and, thus, gene expression. Likewise, snRNPs provide another important target for using antisense oligonucleotides as investigative tools to further study the mechanism of splicing. This article reviews the available literature on the use of antisense oligonucleotides targeted against pre-mRNA and those targeted against small nuclear ribonucleoprotein particles (snRNPs) within the spliceosomal complex.

Url:

https://api.istex.fr/ark:/67375/6H6-C04RM7G7-7/fulltext.pdf

DOI: 10.1016/0169-409X(91)90021-4

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000E82
to stream Istex, to step Curation: 000E82
to stream Istex, to step Checkpoint: 001E53
to stream Main, to step Merge: 004986
to stream Main, to step Curation: 004910

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Pre-mRNA splicing as a target for antisense oligonucleotides</title>
<author><name sortKey="Kole, Ryszard" sort="Kole, Ryszard" uniqKey="Kole R" first="Ryszard" last="Kole">Ryszard Kole</name>
</author>
<author><name sortKey="Shukla, Ram R" sort="Shukla, Ram R" uniqKey="Shukla R" first="Ram R." last="Shukla">Ram R. Shukla</name>
</author>
<author><name sortKey="Akhtar, Saghir" sort="Akhtar, Saghir" uniqKey="Akhtar S" first="Saghir" last="Akhtar">Saghir Akhtar</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:182C0B5F1611BB8E2B8203EAC9B4DE94CC553472</idno>
<date when="1991" year="1991">1991</date>
<idno type="doi">10.1016/0169-409X(91)90021-4</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-C04RM7G7-7/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000E82</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E82</idno>
<idno type="wicri:Area/Istex/Curation">000E82</idno>
<idno type="wicri:Area/Istex/Checkpoint">001E53</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001E53</idno>
<idno type="wicri:doubleKey">0169-409X:1991:Kole R:pre:mrna:splicing</idno>
<idno type="wicri:Area/Main/Merge">004986</idno>
<idno type="wicri:Area/Main/Curation">004910</idno>
<idno type="wicri:Area/Main/Exploration">004910</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Pre-mRNA splicing as a target for antisense oligonucleotides</title>
<author><name sortKey="Kole, Ryszard" sort="Kole, Ryszard" uniqKey="Kole R" first="Ryszard" last="Kole">Ryszard Kole</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Lineberger Cancer Research Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
<placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shukla, Ram R" sort="Shukla, Ram R" uniqKey="Shukla R" first="Ram R." last="Shukla">Ram R. Shukla</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Lineberger Cancer Research Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
<placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Akhtar, Saghir" sort="Akhtar, Saghir" uniqKey="Akhtar S" first="Saghir" last="Akhtar">Saghir Akhtar</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Lineberger Cancer Research Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
<placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Advanced Drug Delivery Reviews</title>
<title level="j" type="abbrev">ADR</title>
<idno type="ISSN">0169-409X</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1991">1991</date>
<biblScope unit="volume">6</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="271">271</biblScope>
<biblScope unit="page" to="286">286</biblScope>
</imprint>
<idno type="ISSN">0169-409X</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0169-409X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad</term>
<term>Antisense</term>
<term>Antisense oligonucleotides</term>
<term>Antiviral</term>
<term>Antiviral activity</term>
<term>Biol</term>
<term>Branch point</term>
<term>Branch point sequence</term>
<term>Branch point sequences</term>
<term>Cell membrane</term>
<term>Chapel hill</term>
<term>Cleavage</term>
<term>Cultured cells</term>
<term>Exon</term>
<term>Exon sequences</term>
<term>First step</term>
<term>Form duplexes</term>
<term>Gene expression</term>
<term>Herpes simplex virus type</term>
<term>Human immunodeficiency virus</term>
<term>Immunodeficiency</term>
<term>Intron</term>
<term>Intron sequences</term>
<term>Kole</term>
<term>Large number</term>
<term>Mrna</term>
<term>Natl</term>
<term>Nucleic acids</term>
<term>Nucleotide</term>
<term>Oligonucleotide</term>
<term>Oligonucleotides</term>
<term>Oligonucleotides antisense</term>
<term>Phosphorothioate</term>
<term>Proc</term>
<term>Replication</term>
<term>Ribonucleoprotein</term>
<term>Ribonucleoprotein particle</term>
<term>Ribonucleoprotein particles</term>
<term>Rnase</term>
<term>Snrna</term>
<term>Snrnp</term>
<term>Snrnps</term>
<term>Splice</term>
<term>Splice site</term>
<term>Splice sites</term>
<term>Spliceosome</term>
<term>Viral</term>
<term>Zamecnik</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Splicing is one of the major post-transcriptional modifications a eukaryotic mRNA precursor (pre-mRNA) has to undergo to yield the mature mRNA. During pre-mRNA splicing the non-coding sequences (introns) of the precursor are removed and coding sequences (exons) are joined. This process takes place within a complex called a spliceosome and requires the presence of a number of splicing factors such as small nuclear ribonucleoprotein particles (snRNPs). Oligonucleotides containing sequences complementary (antisense) to unique sequences within the pre-mRNA can be used to modify splicing and, thus, gene expression. Likewise, snRNPs provide another important target for using antisense oligonucleotides as investigative tools to further study the mechanism of splicing. This article reviews the available literature on the use of antisense oligonucleotides targeted against pre-mRNA and those targeted against small nuclear ribonucleoprotein particles (snRNPs) within the spliceosomal complex.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
</region>
<settlement><li>Chapel Hill (Caroline du Nord)</li>
</settlement>
<orgName><li>Université de Caroline du Nord à Chapel Hill</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Kole, Ryszard" sort="Kole, Ryszard" uniqKey="Kole R" first="Ryszard" last="Kole">Ryszard Kole</name>
</region>
<name sortKey="Akhtar, Saghir" sort="Akhtar, Saghir" uniqKey="Akhtar S" first="Saghir" last="Akhtar">Saghir Akhtar</name>
<name sortKey="Shukla, Ram R" sort="Shukla, Ram R" uniqKey="Shukla R" first="Ram R." last="Shukla">Ram R. Shukla</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004910 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004910 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:182C0B5F1611BB8E2B8203EAC9B4DE94CC553472
   |texte=   Pre-mRNA splicing as a target for antisense oligonucleotides
}}

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Pre-mRNA splicing as a target for antisense oligonucleotides

Pre-mRNA splicing as a target for antisense oligonucleotides

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri