Immunopotentiation of bovine respiratory disease virus vaccines by interleukin-1 β and interleukin-2
Identifieur interne : 004573 ( Main/Exploration ); précédent : 004572; suivant : 004574Immunopotentiation of bovine respiratory disease virus vaccines by interleukin-1 β and interleukin-2
Auteurs : D. N. Reddy [États-Unis] ; P. G. Reddy [États-Unis] ; W. Xue [États-Unis] ; H. C. Minocha [États-Unis] ; M. J. Daley [États-Unis] ; F. Blecha [États-Unis]Source :
- Veterinary Immunology and Immunopathology [ 0165-2427 ] ; 1993.
English descriptors
- Teeft :
- Adjuvant, Adverse effects, Adverse side effects, Antibody tlters, Blecha, Bovine, Bovine mterleukln, Bovine respirator, Calf, Common superscripts, Control calves, Cytokine, Cytoklne, Cytoklne administration, Cytolytlc activity, Cytotoxic responses, Cytotoxlc, Cytotoxlc responses, Disease virus vaccines, Domestic food ammals, Effective adjuvants, Experiment blood samples, High dose, Immunol immunopathol, Mdbk cells, Nasal secretions, Other treatment groups, Peripheral blood, Present data, Rboil, Rectal temperatures, Target cells, Tlters, Treatment control, Treatment groups, Vaccinated, Vaccinated control calves, Vaccine, Virus vaccine.
Abstract
Abstract: Three experiments, using 85 crossbred beef calves, were conducted to evaluate the adjuvanticity of single, multiple, and combined doses of recombinant bovine IL-1 β (rBoIL-1 β) and recombinant bovine IL-2 (rBoIL-2), with a modified-live bovine herpesvirus-1/parainfluenza-3 (BHV-1/PI-3) virus vaccine and a killed bovine viral diarrhea (BVD) virus vaccine. Cytokines were administered intramuscularly at vaccination but at different injection sites. All cytokine treatments increased non-major histocompatibility complex (MHC)-restricted cytolytic capability of peripheral blood mononuclear cells (PBMC) against virus-infected target cells and serum neutralizing (SN) antibody titers to BHV-1 and BVD virus. Multiple, consecutive injections of rBoIL-2 generally showed the greatest adjuvant effect, and no additive effect was observed when rBoIL-1 β and rBoIL-2 were administered together. In a challenge experiment, calves were vaccinated with a modified-live BHV-1/PI-3 vaccine and infected with BHV-1 on Day 21. Cytokine-treated calves had higher SN antibody titers to BHV-1 than did the control calves at the time of challenge. Calves that were administered rBoIL-2 on 5 consecutive days shed less BHV-1 and had the highest SN antibody titer to BHV-1 (Day 28). These data suggest that rBoIL-1 β and rBoIL-2 may be useful immunoadjuvants for bovine respiratory disease virus vaccines.
Url:
DOI: 10.1016/0165-2427(93)90013-T
Affiliations:
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Blecha, Departments of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506</wicri:regionArea><wicri:noRegion>KS 66506</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506</wicri:regionArea><wicri:noRegion>KS 66506</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Veterinary Immunology and Immunopathology</title><title level="j" type="abbrev">VETIMM</title><idno type="ISSN">0165-2427</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">37</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="25">25</biblScope><biblScope unit="page" to="38">38</biblScope></imprint><idno type="ISSN">0165-2427</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-2427</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adjuvant</term><term>Adverse effects</term><term>Adverse side effects</term><term>Antibody tlters</term><term>Blecha</term><term>Bovine</term><term>Bovine mterleukln</term><term>Bovine respirator</term><term>Calf</term><term>Common superscripts</term><term>Control calves</term><term>Cytokine</term><term>Cytoklne</term><term>Cytoklne administration</term><term>Cytolytlc activity</term><term>Cytotoxic responses</term><term>Cytotoxlc</term><term>Cytotoxlc responses</term><term>Disease virus vaccines</term><term>Domestic food ammals</term><term>Effective adjuvants</term><term>Experiment blood samples</term><term>High dose</term><term>Immunol immunopathol</term><term>Mdbk cells</term><term>Nasal secretions</term><term>Other treatment groups</term><term>Peripheral blood</term><term>Present data</term><term>Rboil</term><term>Rectal temperatures</term><term>Target cells</term><term>Tlters</term><term>Treatment control</term><term>Treatment groups</term><term>Vaccinated</term><term>Vaccinated control calves</term><term>Vaccine</term><term>Virus vaccine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Three experiments, using 85 crossbred beef calves, were conducted to evaluate the adjuvanticity of single, multiple, and combined doses of recombinant bovine IL-1 β (rBoIL-1 β) and recombinant bovine IL-2 (rBoIL-2), with a modified-live bovine herpesvirus-1/parainfluenza-3 (BHV-1/PI-3) virus vaccine and a killed bovine viral diarrhea (BVD) virus vaccine. Cytokines were administered intramuscularly at vaccination but at different injection sites. All cytokine treatments increased non-major histocompatibility complex (MHC)-restricted cytolytic capability of peripheral blood mononuclear cells (PBMC) against virus-infected target cells and serum neutralizing (SN) antibody titers to BHV-1 and BVD virus. Multiple, consecutive injections of rBoIL-2 generally showed the greatest adjuvant effect, and no additive effect was observed when rBoIL-1 β and rBoIL-2 were administered together. In a challenge experiment, calves were vaccinated with a modified-live BHV-1/PI-3 vaccine and infected with BHV-1 on Day 21. Cytokine-treated calves had higher SN antibody titers to BHV-1 than did the control calves at the time of challenge. Calves that were administered rBoIL-2 on 5 consecutive days shed less BHV-1 and had the highest SN antibody titer to BHV-1 (Day 28). These data suggest that rBoIL-1 β and rBoIL-2 may be useful immunoadjuvants for bovine respiratory disease virus vaccines.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Reddy, D N" sort="Reddy, D N" uniqKey="Reddy D" first="D. N." last="Reddy">D. N. Reddy</name></noRegion><name sortKey="Blecha, F" sort="Blecha, F" uniqKey="Blecha F" first="F." last="Blecha">F. Blecha</name><name sortKey="Blecha, F" sort="Blecha, F" uniqKey="Blecha F" first="F." last="Blecha">F. Blecha</name><name sortKey="Daley, M J" sort="Daley, M J" uniqKey="Daley M" first="M. J." last="Daley">M. J. Daley</name><name sortKey="Minocha, H C" sort="Minocha, H C" uniqKey="Minocha H" first="H. C." last="Minocha">H. C. Minocha</name><name sortKey="Reddy, D N" sort="Reddy, D N" uniqKey="Reddy D" first="D. N." last="Reddy">D. N. Reddy</name><name sortKey="Reddy, P G" sort="Reddy, P G" uniqKey="Reddy P" first="P. G." last="Reddy">P. G. Reddy</name><name sortKey="Xue, W" sort="Xue, W" uniqKey="Xue W" first="W." last="Xue">W. Xue</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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