Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins
Identifieur interne : 004546 ( Main/Exploration ); précédent : 004545; suivant : 004547Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins
Auteurs : Rodney E. Willoughby [États-Unis]Source :
- Glycobiology [ 0959-6658 ] ; 1993.
Abstract
Rotaviruses are the most common cause of severe gastroenteritis in infants and children worldwide. Early events of virus binding and entry are the critical determinants of cellular permissiveness to rotavirus replication. The only known ligands for rotaviruses are sialic acids. We now report that simian rotaviruses bind preferentially to a subset of sialylated glycoconjugates, i.e. glycoproteins containing O-linked sialic acid moieties. Rotaviruses are able to distinguish between sialylated trisaccharide ligands presented as neoglycolipids. Higher avidity binding by rotaviruses is explained by multivalent binding to clustered sialic acid moieties. Our in vitro data are extended to explain the protective effect of mucins in the murine model of rotavirus disease and the specific binding by rotavirus to a high molecular weight sialomucin in the infant mouse intestine. Rotavirus binding to a sialomucin may be analogous to selectin-mediated mechanisms of cellular adhesion, and may be advantageous to the virus in the dynamic environment of the intestine.
Url:
DOI: 10.1093/glycob/3.5.437
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001818
- to stream Istex, to step Curation: 001818
- to stream Istex, to step Checkpoint: 001B57
- to stream Main, to step Merge: 004612
- to stream Main, to step Curation: 004546
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins</title><author wicri:is="90%"><name sortKey="Willoughby, Rodney E" sort="Willoughby, Rodney E" uniqKey="Willoughby R" first="Rodney E." last="Willoughby">Rodney E. Willoughby</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8134435FB047416E42CD16A8C42E41BC8DF3C9C2</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1093/glycob/3.5.437</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-L9W5B19H-L/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001818</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001818</idno><idno type="wicri:Area/Istex/Curation">001818</idno><idno type="wicri:Area/Istex/Checkpoint">001B57</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001B57</idno><idno type="wicri:doubleKey">0959-6658:1993:Willoughby R:rotaviruses:preferentially:bind</idno><idno type="wicri:Area/Main/Merge">004612</idno><idno type="wicri:Area/Main/Curation">004546</idno><idno type="wicri:Area/Main/Exploration">004546</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins</title><author wicri:is="90%"><name sortKey="Willoughby, Rodney E" sort="Willoughby, Rodney E" uniqKey="Willoughby R" first="Rodney E." last="Willoughby">Rodney E. Willoughby</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eudowood Division of Infectious Diseases, Department of Pediatrics, The Johns Hopkins Medical School, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Glycobiology</title><idno type="eISSN">1460-2423</idno><idno type="ISSN">0959-6658</idno><imprint><publisher>Oxford University Press</publisher><date type="published">1993</date><biblScope unit="vol">3</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="437">437</biblScope><biblScope unit="page" to="445">445</biblScope></imprint><idno type="ISSN">0959-6658</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-6658</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Rotaviruses are the most common cause of severe gastroenteritis in infants and children worldwide. Early events of virus binding and entry are the critical determinants of cellular permissiveness to rotavirus replication. The only known ligands for rotaviruses are sialic acids. We now report that simian rotaviruses bind preferentially to a subset of sialylated glycoconjugates, i.e. glycoproteins containing O-linked sialic acid moieties. Rotaviruses are able to distinguish between sialylated trisaccharide ligands presented as neoglycolipids. Higher avidity binding by rotaviruses is explained by multivalent binding to clustered sialic acid moieties. Our in vitro data are extended to explain the protective effect of mucins in the murine model of rotavirus disease and the specific binding by rotavirus to a high molecular weight sialomucin in the infant mouse intestine. Rotavirus binding to a sialomucin may be analogous to selectin-mediated mechanisms of cellular adhesion, and may be advantageous to the virus in the dynamic environment of the intestine.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Willoughby, Rodney E" sort="Willoughby, Rodney E" uniqKey="Willoughby R" first="Rodney E." last="Willoughby">Rodney E. Willoughby</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004546 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004546 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:8134435FB047416E42CD16A8C42E41BC8DF3C9C2
|texte= Rotaviruses preferentially bind O-linked sialylglycoconjugates and sialomucins
}}
| This area was generated with Dilib version V0.6.33. |  |