Encoded latent membrane protein 1 of Epstein-Barr virus on follicular dendritic cells in residual germinal centres in Hodgkin's disease.
Identifieur interne : 004455 ( Main/Exploration ); précédent : 004454; suivant : 004456Encoded latent membrane protein 1 of Epstein-Barr virus on follicular dendritic cells in residual germinal centres in Hodgkin's disease.
Auteurs : J. Van Gorp [Pays-Bas] ; K C Jacobse [Pays-Bas] ; R. Broekhuizen [Pays-Bas] ; J. Alers [Pays-Bas] ; J G Van Den Tweel [Pays-Bas] ; R A De Weger [Pays-Bas]Source :
- Journal of Clinical Pathology [ 0021-9746 ] ; 1994-01.
English descriptors
- Teeft :
- Alers, Antibody cocktail, Antibody response, Broekhuizen, Centre, Cytotoxic, Dako, Dendritic, Eber, Eber positivity, Endogenous peroxidase activity, First step, Follicular, Follicular dendritic cells, Gene products, Germinal, Germinal centres, Gorp, Hodgkins disease, Hybridisation, Immune, Immunoperoxidase procedure, Jacobse, Latent membrane protein, Lymph, Lymphocyte, Lymphoid, Malignant, Malignant cells, Mchd, Monoclonal antibodies, Node, Nodular sclerosing, Nshd, Organosilane pretreated glass slides, Peroxidase, Positive cases, Positivity, Reactive, Reactive lymph nodes, Receptor, Reed stemnberg cells, Rickinson, Serial sections, Strong correlation, Tissue sections, Tweel, University hospital, Weger.
Abstract
AIMS--To determine if there is an association between Epstein-Barr virus (EBV) infection and Hodgkin's disease. METHODS--Fifty cases of Hodgkin's disease and 25 reactive lymph nodes were screened for the presence of EBV-RNA (EBER) using in situ hybridisation, and for the expression of EBV encoded latent membrane protein 1 (LMP-1) by immunohistochemistry. RESULTS--In 42% of the cases of Hodgkin's disease, EBER was detected in the nuclei of the malignant cells, and in LMP-1 expression was found 36%. Both EBER and LMP-1 positivity were seen in 34% of the cases. An additional finding was the presence of LMP-1 on follicular dendritic cells in residual germinal centres in two cases of Hodgkin's disease. EBER was not detected in these germinal centres. In reactive lymph nodes only occasional EBER positive, small, lymphoid cells were found, without LMP-1 expression. CONCLUSIONS--These results show a strong correlation between the presence of EBER and the LMP-1 expression in the Reed-Sternberg cells. They corroborate a role for EBV in at least some cases of Hodgkin's disease. LMP-1 is probably presented as an immune complex in the germinal centres, as part of an immune response against EBV.
Url:
DOI: 10.1136/jcp.47.1.29
Affiliations:
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Alers</name></author><author><name sortKey="Van Den Tweel, J G" sort="Van Den Tweel, J G" uniqKey="Van Den Tweel J" first="J G" last="Van Den Tweel">J G Van Den Tweel</name></author><author><name sortKey="De Weger, R A" sort="De Weger, R A" uniqKey="De Weger R" first="R A" last="De Weger">R A De Weger</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2C46C03AE49C32FC16665AC437F86FD5C701C5D5</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1136/jcp.47.1.29</idno><idno type="url">https://api.istex.fr/ark:/67375/NVC-T1MN5QC1-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000863</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000863</idno><idno type="wicri:Area/Istex/Curation">000863</idno><idno type="wicri:Area/Istex/Checkpoint">001A92</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001A92</idno><idno type="wicri:doubleKey">0021-9746:1994:Van Gorp J:encoded:latent:membrane</idno><idno type="wicri:Area/Main/Merge">004518</idno><idno type="wicri:Area/Main/Curation">004455</idno><idno type="wicri:Area/Main/Exploration">004455</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Encoded latent membrane protein 1 of Epstein-Barr virus on follicular dendritic cells in residual germinal centres in Hodgkin's disease.</title><author><name sortKey="Van Gorp, J" sort="Van Gorp, J" uniqKey="Van Gorp J" first="J" last="Van Gorp">J. Van Gorp</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, University Hospital, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Jacobse, K C" sort="Jacobse, K C" uniqKey="Jacobse K" first="K C" last="Jacobse">K C Jacobse</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, University Hospital, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Broekhuizen, R" sort="Broekhuizen, R" uniqKey="Broekhuizen R" first="R" last="Broekhuizen">R. Broekhuizen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, University Hospital, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Alers, J" sort="Alers, J" uniqKey="Alers J" first="J" last="Alers">J. Alers</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, University Hospital, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Van Den Tweel, J G" sort="Van Den Tweel, J G" uniqKey="Van Den Tweel J" first="J G" last="Van Den Tweel">J G Van Den Tweel</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, University Hospital, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="De Weger, R A" sort="De Weger, R A" uniqKey="De Weger R" first="R A" last="De Weger">R A De Weger</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, University Hospital, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Clinical Pathology</title><title level="j" type="abbrev">J Clin Pathol</title><idno type="ISSN">0021-9746</idno><idno type="eISSN">1472-4146</idno><imprint><publisher>BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><date type="published" when="1994-01">1994-01</date><biblScope unit="volume">47</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="29">29</biblScope></imprint><idno type="ISSN">0021-9746</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9746</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Alers</term><term>Antibody cocktail</term><term>Antibody response</term><term>Broekhuizen</term><term>Centre</term><term>Cytotoxic</term><term>Dako</term><term>Dendritic</term><term>Eber</term><term>Eber positivity</term><term>Endogenous peroxidase activity</term><term>First step</term><term>Follicular</term><term>Follicular dendritic cells</term><term>Gene products</term><term>Germinal</term><term>Germinal centres</term><term>Gorp</term><term>Hodgkins disease</term><term>Hybridisation</term><term>Immune</term><term>Immunoperoxidase procedure</term><term>Jacobse</term><term>Latent membrane protein</term><term>Lymph</term><term>Lymphocyte</term><term>Lymphoid</term><term>Malignant</term><term>Malignant cells</term><term>Mchd</term><term>Monoclonal antibodies</term><term>Node</term><term>Nodular sclerosing</term><term>Nshd</term><term>Organosilane pretreated glass slides</term><term>Peroxidase</term><term>Positive cases</term><term>Positivity</term><term>Reactive</term><term>Reactive lymph nodes</term><term>Receptor</term><term>Reed stemnberg cells</term><term>Rickinson</term><term>Serial sections</term><term>Strong correlation</term><term>Tissue sections</term><term>Tweel</term><term>University hospital</term><term>Weger</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">AIMS--To determine if there is an association between Epstein-Barr virus (EBV) infection and Hodgkin's disease. METHODS--Fifty cases of Hodgkin's disease and 25 reactive lymph nodes were screened for the presence of EBV-RNA (EBER) using in situ hybridisation, and for the expression of EBV encoded latent membrane protein 1 (LMP-1) by immunohistochemistry. RESULTS--In 42% of the cases of Hodgkin's disease, EBER was detected in the nuclei of the malignant cells, and in LMP-1 expression was found 36%. Both EBER and LMP-1 positivity were seen in 34% of the cases. An additional finding was the presence of LMP-1 on follicular dendritic cells in residual germinal centres in two cases of Hodgkin's disease. EBER was not detected in these germinal centres. In reactive lymph nodes only occasional EBER positive, small, lymphoid cells were found, without LMP-1 expression. CONCLUSIONS--These results show a strong correlation between the presence of EBER and the LMP-1 expression in the Reed-Sternberg cells. They corroborate a role for EBV in at least some cases of Hodgkin's disease. LMP-1 is probably presented as an immune complex in the germinal centres, as part of an immune response against EBV.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Utrecht (province)</li></region><settlement><li>Utrecht</li></settlement></list><tree><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Van Gorp, J" sort="Van Gorp, J" uniqKey="Van Gorp J" first="J" last="Van Gorp">J. Van Gorp</name></region><name sortKey="Alers, J" sort="Alers, J" uniqKey="Alers J" first="J" last="Alers">J. Alers</name><name sortKey="Broekhuizen, R" sort="Broekhuizen, R" uniqKey="Broekhuizen R" first="R" last="Broekhuizen">R. Broekhuizen</name><name sortKey="De Weger, R A" sort="De Weger, R A" uniqKey="De Weger R" first="R A" last="De Weger">R A De Weger</name><name sortKey="Jacobse, K C" sort="Jacobse, K C" uniqKey="Jacobse K" first="K C" last="Jacobse">K C Jacobse</name><name sortKey="Van Den Tweel, J G" sort="Van Den Tweel, J G" uniqKey="Van Den Tweel J" first="J G" last="Van Den Tweel">J G Van Den Tweel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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