MersV1, Main, Exploration, bibRecord, 004027

Nicorandil suppressed myocardial purine metabolism during exercise in patients with angina pectoris.

Identifieur interne : 004027 ( Main/Exploration ); précédent : 004026; suivant : 004028

Nicorandil suppressed myocardial purine metabolism during exercise in patients with angina pectoris.

Auteurs : K. Ogino [Japon] ; S. Osaki ; N. Noguchi ; H. Kitamura ; H. Omodani ; M. Kato ; I. Hisatome ; T. Matsumoto ; T. Kinugawa ; H. Miyakoda

Source :

European journal of clinical pharmacology [ 0031-6970 ] ; 1995.

RBID : pubmed:7589040

Descripteurs français

KwdFr :
- Administration par voie orale, Adulte d'âge moyen, Angine de poitrine (traitement médicamenteux), Coeur (), Effet placébo, Exercice physique, Facteurs temps, Femelle, Humains, Mâle, Métabolisme énergétique (), Nicorandil, Nicotinamide (analogues et dérivés), Nicotinamide (pharmacologie), Pression sanguine (), Purines (métabolisme), Rythme cardiaque (), Sujet âgé, Vasodilatateurs (pharmacologie).
MESH :
- analogues et dérivés : Nicotinamide.
- métabolisme : Purines.
- pharmacologie : Nicotinamide, Vasodilatateurs.
- traitement médicamenteux : Angine de poitrine.
- Administration par voie orale, Adulte d'âge moyen, Coeur, Effet placébo, Exercice physique, Facteurs temps, Femelle, Humains, Mâle, Métabolisme énergétique, Nicorandil, Pression sanguine, Rythme cardiaque, Sujet âgé.

English descriptors

KwdEn :
- Administration, Oral, Aged, Angina Pectoris (drug therapy), Blood Pressure (drug effects), Energy Metabolism (drug effects), Exercise, Female, Heart (drug effects), Heart Rate (drug effects), Humans, Male, Middle Aged, Niacinamide (analogs & derivatives), Niacinamide (pharmacology), Nicorandil, Placebo Effect, Purines (metabolism), Time Factors, Vasodilator Agents (pharmacology).
MESH :
- chemical , analogs & derivatives : Niacinamide.
- drug effects : Blood Pressure, Energy Metabolism, Heart, Heart Rate.
- drug therapy : Angina Pectoris.
- chemical , metabolism : Purines.
- chemical , pharmacology : Niacinamide, Vasodilator Agents.
- Administration, Oral, Aged, Exercise, Female, Humans, Male, Middle Aged, Nicorandil, Placebo Effect, Time Factors.

Abstract

To elucidate the effect of Nicorandil on myocardial energy metabolism and myocardial sympathetic activity, we administered Nicorandil orally to eight patients with angina pectoris prior to exercise testing. Arterial and coronary sinus levels of lactate, ammonia, hypoxanthine (HX), adrenaline and noradrenaline were measured during exercise in order to determine the irrespective myocardial extraction ratios (MER). Compared to placebo, Nicorandil increased the time to development of significant ST depression (322 vs 390 s) while decreasing the maximum amplitude of ST depression (0.244 vs 0.216 mV). Heart rate, systolic blood pressure, and the rate pressure product during exercise were not significantly affected. The MER of lactate, measured during exercise, was significantly higher after Nicorandil than placebo (13.6 vs 27.9). Similarly, the MERs of ammonia and HX were significantly higher after Nicorandil (-46.0 vs 7.4% and -47.0 vs 9.9% respectively). Nicorandil, had no apparent effect on myocardial sympathetic activity as the MERs of adrenaline and noradrenaline were essentially unaffected. We conclude that Nicorandil decreased myocardial ischaemia and suppressed myocardial accelerated purine metabolism (a marker of cellular energy metabolism) during exercise in patients with angina pectoris. This effect appears not to be related to myocardial sympathetic activity.

DOI: 10.1007/bf00198297
PubMed: 7589040

Affiliations:

Japon

Le document en format XML

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<term>Blood Pressure (drug effects)</term>
<term>Energy Metabolism (drug effects)</term>
<term>Exercise</term>
<term>Female</term>
<term>Heart (drug effects)</term>
<term>Heart Rate (drug effects)</term>
<term>Humans</term>
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<term>Middle Aged</term>
<term>Niacinamide (analogs & derivatives)</term>
<term>Niacinamide (pharmacology)</term>
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<term>Purines (metabolism)</term>
<term>Time Factors</term>
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<term>Coeur ()</term>
<term>Effet placébo</term>
<term>Exercice physique</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
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<term>Nicotinamide (analogues et dérivés)</term>
<term>Nicotinamide (pharmacologie)</term>
<term>Pression sanguine ()</term>
<term>Purines (métabolisme)</term>
<term>Rythme cardiaque ()</term>
<term>Sujet âgé</term>
<term>Vasodilatateurs (pharmacologie)</term>
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<term>Energy Metabolism</term>
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<term>Heart Rate</term>
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<front><div type="abstract" xml:lang="en">To elucidate the effect of Nicorandil on myocardial energy metabolism and myocardial sympathetic activity, we administered Nicorandil orally to eight patients with angina pectoris prior to exercise testing. Arterial and coronary sinus levels of lactate, ammonia, hypoxanthine (HX), adrenaline and noradrenaline were measured during exercise in order to determine the irrespective myocardial extraction ratios (MER). Compared to placebo, Nicorandil increased the time to development of significant ST depression (322 vs 390 s) while decreasing the maximum amplitude of ST depression (0.244 vs 0.216 mV). Heart rate, systolic blood pressure, and the rate pressure product during exercise were not significantly affected. The MER of lactate, measured during exercise, was significantly higher after Nicorandil than placebo (13.6 vs 27.9). Similarly, the MERs of ammonia and HX were significantly higher after Nicorandil (-46.0 vs 7.4% and -47.0 vs 9.9% respectively). Nicorandil, had no apparent effect on myocardial sympathetic activity as the MERs of adrenaline and noradrenaline were essentially unaffected. We conclude that Nicorandil decreased myocardial ischaemia and suppressed myocardial accelerated purine metabolism (a marker of cellular energy metabolism) during exercise in patients with angina pectoris. This effect appears not to be related to myocardial sympathetic activity.</div>
</front>
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Serveur d'exploration MERS

Nicorandil suppressed myocardial purine metabolism during exercise in patients with angina pectoris.

Nicorandil suppressed myocardial purine metabolism during exercise in patients with angina pectoris.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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