A good antisense molecule is hard to find
Identifieur interne : 003B01 ( Main/Exploration ); précédent : 003B00; suivant : 003B02A good antisense molecule is hard to find
Auteurs : Andrea D. Branch [États-Unis]Source :
- Trends in Biochemical Sciences [ 0968-0004 ] ; 1998.
English descriptors
- Teeft :
- Acid drug, Acid drugs, Antisense, Antisense compounds, Antisense drugs, Antisense molecule, Antisense molecules, Antisense specificity, Antisense strategies, Antisense therapies, Base pairing, Base pairs, Bioengineered ribozymes, Biological sequences, Biotechnol, Bystander, Cell type, Cellular proteins, Cleavage, Columbia university, Complementary sites, Conventional drugs, Doseresponse curves, Effective antisense molecules, Globin mrna, Intramolecular bonds, Isis pharmaceuticals, Many rnas, Molecule, Mrna, Nucleic, Nucleic acid drugs, Nucleic acids, Odns, Other rnas, Pharmaceutical, Phosphodiester odns, Point tibs, Proc, Rational design, Reagent, Recognition sequence, Research reagents, Ribozymes, Rna, Rnase, Sinai school, Single gene, Target mrna, Target rnas, Theoretical limits, Trends biochem, Unwanted effects, Xenopus oocytes.
Abstract
Abstract: Antisense molecules and ribozymes capture the imagination with their promise of rational drug design and exquisite specificity. However, they are far more difficult to produce than was originally anticipated, and their ability to eliminate the function of a single gene has never been proven. Furthermore, a wide variety of unexpected non-antisense effects have come to light. Although some of these side effects will almost certainly have clinical value, they make it hard to produce drugs that act primarily through true antisense mechanisms and complicate the use of antisense compounds as research reagents. To minimize unwanted non-antisense effects, investigators are searching for antisense compounds and ribozymes whose target sites are particularly vulnerable to attack. This is a challenging quest.
Url:
DOI: 10.1016/S0968-0004(97)01155-9
Affiliations:
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Le document en format XML
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Branch</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>A. D. Branch is in the Division of Liver Diseases, Box 1633, Department of Medicine, The Mount Sinai School of Medicine, One Gustave L. 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However, they are far more difficult to produce than was originally anticipated, and their ability to eliminate the function of a single gene has never been proven. Furthermore, a wide variety of unexpected non-antisense effects have come to light. Although some of these side effects will almost certainly have clinical value, they make it hard to produce drugs that act primarily through true antisense mechanisms and complicate the use of antisense compounds as research reagents. To minimize unwanted non-antisense effects, investigators are searching for antisense compounds and ribozymes whose target sites are particularly vulnerable to attack. This is a challenging quest.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Branch, Andrea D" sort="Branch, Andrea D" uniqKey="Branch A" first="Andrea D." last="Branch">Andrea D. 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