Citrullinated myelin basic protein induces experimental autoimmune encephalomyelitis in Lewis rats through a diverse T cell repertoire
Identifieur interne : 003A84 ( Main/Exploration ); précédent : 003A83; suivant : 003A85Citrullinated myelin basic protein induces experimental autoimmune encephalomyelitis in Lewis rats through a diverse T cell repertoire
Auteurs : Ligong Cao [États-Unis] ; Deming Sun [États-Unis] ; John N. Whitaker [États-Unis]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1998.
English descriptors
- Teeft :
- Assay, Brain tissue, Cation exchange chromatography, Cell harvest, Cell line, Cell lines, Cell proliferation assay, Cell repertoire, Cell response, Cell subsets, Cells welly1, Citrullinated, Citrullinated isomer, Citrullination, Encephalitogenic, Encephalomyelitis, Epitope, Hindlimb, Histopathological examination, Human myelin, Immune response, Immunization, Immunol, Isomer, Lewis rats, Lymph node cells, Microtiter plates, Mly1, Monoclonal antibodies, Moscarello, Multiple sclerosis, Myelin, Neuroimmunology, Node, Peptide, Preferential response, Rat, Reinduction, Sclerosis, Spinal cords, Stimulation medium, Syngeneic thymocytes, Thymocytes, Welly1, Whitaker, Zhou.
Abstract
Abstract: An increased proportion of citrullinated MBP (MBP-C8) occurs in the brains of multiple sclerosis (MS) patients. In this study, MBP-C8 from guinea pig (GP) brains was isolated and found encephalitogenic in Lewis rats upon immunization. An encephalitogenic T cell line selected with MBP-C8 preferentially reacted with MBP-C8 over unmodified MBP. This T cell line responded weakly to the dominant encephalitogenic epitope, GP-MBP peptide 70–88, and did not display restricted TCR β-chain usage (such as Vβ8.2). The distinctive features of MBP-C8 were also demonstrated by its ability to reinduce active EAE in 70% of rats which had recovered from unmodified MBP induced EAE. These findings raise the possibility that citrullinated MBP may elicit a different pathogenic T cell repertoire for the recurrent phases of inflammatory demyelination.
Url:
DOI: 10.1016/S0165-5728(98)00063-0
Affiliations:
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In this study, MBP-C8 from guinea pig (GP) brains was isolated and found encephalitogenic in Lewis rats upon immunization. An encephalitogenic T cell line selected with MBP-C8 preferentially reacted with MBP-C8 over unmodified MBP. This T cell line responded weakly to the dominant encephalitogenic epitope, GP-MBP peptide 70–88, and did not display restricted TCR β-chain usage (such as Vβ8.2). The distinctive features of MBP-C8 were also demonstrated by its ability to reinduce active EAE in 70% of rats which had recovered from unmodified MBP induced EAE. These findings raise the possibility that citrullinated MBP may elicit a different pathogenic T cell repertoire for the recurrent phases of inflammatory demyelination.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Cao, Ligong" sort="Cao, Ligong" uniqKey="Cao L" first="Ligong" last="Cao">Ligong Cao</name></noRegion><name sortKey="Sun, Deming" sort="Sun, Deming" uniqKey="Sun D" first="Deming" last="Sun">Deming Sun</name><name sortKey="Whitaker, John N" sort="Whitaker, John N" uniqKey="Whitaker J" first="John N" last="Whitaker">John N. Whitaker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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