The response of human B lymphocytes to oligodeoxynucleotides
Identifieur interne : 003682 ( Main/Exploration ); précédent : 003681; suivant : 003683The response of human B lymphocytes to oligodeoxynucleotides
Auteurs : Hua Liang [États-Unis] ; Peter E. Lipsky [États-Unis]Source :
- Springer Seminars in Immunopathology [ 0344-4325 ] ; 2000-03-01.
Abstract
Conclusios: ISS induce T cell-independent polyclonal activation of human B cell by engaging surface Ig. Manifestations of ISS-induced human B cell activation include expression of activation markers, proliferation, and Ig production as well as anti-DNA antibody production. IL-2, IL-6 and intact T cells enhanced B cell responses to ISS, but were not required for B cell activation. Human monocytes enhanced B cell responses induced by ISS, particularly Ig secretion. The chemical nature of sODNs capable of stimulating human B cells has not been completely delineated. Further studies will be necessary and important for developing novel therapeutic and preventive agents in humans using ISS.
Url:
DOI: 10.1007/s002810000017
Affiliations:
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