A novel approach for the identification of unique tumor vasculature binding peptides using an E. coli peptide display library.
Identifieur interne : 003632 ( Main/Exploration ); précédent : 003631; suivant : 003633A novel approach for the identification of unique tumor vasculature binding peptides using an E. coli peptide display library.
Auteurs : C K Brown [États-Unis] ; R A Modzelewski ; C S Johnson ; M K WongSource :
- Annals of surgical oncology [ 1068-9265 ] ; 2000.
Descripteurs français
- KwdFr :
- Animaux, Banque de peptides, Carcinome épidermoïde, Cellules 3T3, Cellules cancéreuses en culture, Endothélium (métabolisme), Escherichia coli, Liaison aux protéines, Motifs d'acides aminés, Néovascularisation pathologique (anatomopathologie), Néovascularisation pathologique (métabolisme), Souris, Souris de lignée C3H, Tumeurs (), Tumeurs (anatomopathologie), Tumeurs (métabolisme).
- MESH :
- anatomopathologie : Néovascularisation pathologique, Tumeurs.
- métabolisme : Endothélium, Néovascularisation pathologique, Tumeurs.
- Animaux, Banque de peptides, Carcinome épidermoïde, Cellules 3T3, Cellules cancéreuses en culture, Escherichia coli, Liaison aux protéines, Motifs d'acides aminés, Souris, Souris de lignée C3H, Tumeurs.
English descriptors
- KwdEn :
- 3T3 Cells, Amino Acid Motifs, Animals, Carcinoma, Squamous Cell, Endothelium (metabolism), Escherichia coli, Mice, Mice, Inbred C3H, Neoplasms (blood supply), Neoplasms (metabolism), Neoplasms (pathology), Neovascularization, Pathologic (metabolism), Neovascularization, Pathologic (pathology), Peptide Library, Protein Binding, Tumor Cells, Cultured.
- MESH :
- chemical : Peptide Library.
- blood supply : Neoplasms.
- metabolism : Endothelium, Neoplasms, Neovascularization, Pathologic.
- pathology : Neoplasms, Neovascularization, Pathologic.
- 3T3 Cells, Amino Acid Motifs, Animals, Carcinoma, Squamous Cell, Escherichia coli, Mice, Mice, Inbred C3H, Protein Binding, Tumor Cells, Cultured.
Abstract
Tumor neovascularization is necessary for continued tumor growth and metastasis. During the process of endothelial cell (EC) recruitment and tumor infiltration, specific molecular markers unique for this interaction are expressed on the EC surface. Targeting these molecular markers would, in effect, allow for specific tumor targeting. Tripeptide sequence motifs have previously been reported that will bind to angiogenic tumor ECs. These sequences were identified from in vivo phage peptide display libraries. The purpose of this study was to use a more simplified bacterial peptide display library in an in vitro system to seek out peptide motifs with unique binding to tumor microvasculature.
DOI: 10.1007/s10434-000-0743-0
PubMed: 11129422
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Tumor neovascularization is necessary for continued tumor growth and metastasis. During the process of endothelial cell (EC) recruitment and tumor infiltration, specific molecular markers unique for this interaction are expressed on the EC surface. Targeting these molecular markers would, in effect, allow for specific tumor targeting. Tripeptide sequence motifs have previously been reported that will bind to angiogenic tumor ECs. These sequences were identified from in vivo phage peptide display libraries. The purpose of this study was to use a more simplified bacterial peptide display library in an in vitro system to seek out peptide motifs with unique binding to tumor microvasculature.</div>
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