MersV1, Main, Exploration, bibRecord, 003446

Complete sequencing of mono-deprotonated peptide nucleic acids by sustained off-resonance irradiation collision-induced dissociation.

Identifieur interne : 003446 ( Main/Exploration ); précédent : 003445; suivant : 003447

Complete sequencing of mono-deprotonated peptide nucleic acids by sustained off-resonance irradiation collision-induced dissociation.

Auteurs : J W Flora [États-Unis] ; D C Muddiman

Source :

Journal of the American Society for Mass Spectrometry [ 1044-0305 ] ; 2001.

RBID : pubmed:11444602

Descripteurs français

KwdFr :
- Acides nucléiques peptidiques (), Analyse de séquence d'ADN, Calibrage, Chimie physique, Phénomènes chimiques, Spectrométrie de masse.
MESH :
- Acides nucléiques peptidiques, Analyse de séquence d'ADN, Calibrage, Chimie physique, Phénomènes chimiques, Spectrométrie de masse.

English descriptors

KwdEn :
- Calibration, Chemical Phenomena, Chemistry, Physical, Mass Spectrometry, Peptide Nucleic Acids (chemistry), Sequence Analysis, DNA.
MESH :
- chemical , chemistry : Peptide Nucleic Acids.
- Calibration, Chemical Phenomena, Chemistry, Physical, Mass Spectrometry, Sequence Analysis, DNA.

Abstract

Complete peptide nucleic acids (PNAs) sequence information is obtained from the unimolecular decomposition of singly-charged PNA oligomers in the negative-ion mode using electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) and sustained off-resonance irradiation collision induced dissociation. The 4-mers, n-CATT-c, n-AGCT-c, n-AACT-c, and n-acetylated-AACT-c and two 6-mers, n-AAAAAA-c and n-CCCCCC-c, were investigated to explore the unimolecular decomposition of mixed-nucleobase and homopolymer PNAs representing purine and pyrimidine oligomers, respectively. PNA decomposition is explored using a product-ion appearance curve and double resonance experiments. A decomposition mechanism for sequence ion formation (PNA amide bond cleavage) is proposed.

DOI: 10.1016/S1044-0305(01)00259-8
PubMed: 11444602

Affiliations:

États-Unis

Le document en format XML

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<wicri:regionArea>Department of Chemistry, Virginia Commonwealth University, Richmond 84206</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Complete sequencing of mono-deprotonated peptide nucleic acids by sustained off-resonance irradiation collision-induced dissociation.</title>
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<term>Sequence Analysis, DNA</term>
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<term>Analyse de séquence d'ADN</term>
<term>Calibrage</term>
<term>Chimie physique</term>
<term>Phénomènes chimiques</term>
<term>Spectrométrie de masse</term>
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<term>Chemical Phenomena</term>
<term>Chemistry, Physical</term>
<term>Mass Spectrometry</term>
<term>Sequence Analysis, DNA</term>
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<term>Analyse de séquence d'ADN</term>
<term>Calibrage</term>
<term>Chimie physique</term>
<term>Phénomènes chimiques</term>
<term>Spectrométrie de masse</term>
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<front><div type="abstract" xml:lang="en">Complete peptide nucleic acids (PNAs) sequence information is obtained from the unimolecular decomposition of singly-charged PNA oligomers in the negative-ion mode using electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) and sustained off-resonance irradiation collision induced dissociation. The 4-mers, n-CATT-c, n-AGCT-c, n-AACT-c, and n-acetylated-AACT-c and two 6-mers, n-AAAAAA-c and n-CCCCCC-c, were investigated to explore the unimolecular decomposition of mixed-nucleobase and homopolymer PNAs representing purine and pyrimidine oligomers, respectively. PNA decomposition is explored using a product-ion appearance curve and double resonance experiments. A decomposition mechanism for sequence ion formation (PNA amide bond cleavage) is proposed.</div>
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Serveur d'exploration MERS

Complete sequencing of mono-deprotonated peptide nucleic acids by sustained off-resonance irradiation collision-induced dissociation.

Complete sequencing of mono-deprotonated peptide nucleic acids by sustained off-resonance irradiation collision-induced dissociation.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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