Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain.
Identifieur interne : 003430 ( Main/Exploration ); précédent : 003429; suivant : 003431Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain.
Auteurs : M R Ziebell [États-Unis] ; Z G Zhao ; B. Luo ; Y. Luo ; E A Turley ; G D PrestwichSource :
- Chemistry & biology [ 1074-5521 ] ; 2001.
Descripteurs français
- KwdFr :
- Acide hyaluronique (), Acide hyaluronique (antagonistes et inhibiteurs), Animaux, Banque de peptides, Fixation compétitive, Glycosaminoglycanes (), Glycosaminoglycanes (antagonistes et inhibiteurs), Humains, Liaison aux protéines, Ligands, Mimétisme moléculaire, Modèles moléculaires, Oligopeptides (), Oligopeptides (métabolisme), Protéines de la matrice extracellulaire (antagonistes et inhibiteurs), Protéines de la matrice extracellulaire (métabolisme), Relation structure-activité, Sites de fixation, Séquence d'acides aminés.
- MESH :
- antagonistes et inhibiteurs : Acide hyaluronique, Glycosaminoglycanes, Protéines de la matrice extracellulaire.
- métabolisme : Oligopeptides, Protéines de la matrice extracellulaire.
- Acide hyaluronique, Animaux, Banque de peptides, Fixation compétitive, Glycosaminoglycanes, Humains, Liaison aux protéines, Ligands, Mimétisme moléculaire, Modèles moléculaires, Oligopeptides, Relation structure-activité, Sites de fixation, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Binding Sites, Binding, Competitive, Extracellular Matrix Proteins (antagonists & inhibitors), Extracellular Matrix Proteins (metabolism), Glycosaminoglycans (antagonists & inhibitors), Glycosaminoglycans (chemistry), Humans, Hyaluronan Receptors (metabolism), Hyaluronic Acid (antagonists & inhibitors), Hyaluronic Acid (chemistry), Ligands, Models, Molecular, Molecular Mimicry, Oligopeptides (chemistry), Oligopeptides (metabolism), Peptide Library, Protein Binding, Structure-Activity Relationship.
- MESH :
- chemical , antagonists & inhibitors : Extracellular Matrix Proteins, Glycosaminoglycans, Hyaluronic Acid.
- chemical , chemistry : Glycosaminoglycans, Hyaluronic Acid, Oligopeptides.
- chemical , metabolism : Extracellular Matrix Proteins, Hyaluronan Receptors, Oligopeptides.
- Amino Acid Sequence, Animals, Binding Sites, Binding, Competitive, Humans, Ligands, Models, Molecular, Molecular Mimicry, Peptide Library, Protein Binding, Structure-Activity Relationship.
Abstract
Hyaluronan (HA) is a non-sulfated glycosaminoglycan (GAG) that promotes motility, adhesion, and proliferation in mammalian cells, as mediated by cell-surface HA receptors. We sought to identify non-carbohydrate ligands that would bind to and activate cell-surface HA receptors. Such analogs could have important therapeutic uses in the treatment of cancer, wound healing, and arthritis, since such ligands would be resistant to degradation by hyaluronidase (HAse).
DOI: 10.1016/s1074-5521(01)00078-3
PubMed: 11731299
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002529
- to stream PubMed, to step Curation: 002529
- to stream PubMed, to step Checkpoint: 002402
- to stream Ncbi, to step Merge: 000117
- to stream Ncbi, to step Curation: 000117
- to stream Ncbi, to step Checkpoint: 000117
- to stream Main, to step Merge: 003466
- to stream Main, to step Curation: 003430
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain.</title><author><name sortKey="Ziebell, M R" sort="Ziebell, M R" uniqKey="Ziebell M" first="M R" last="Ziebell">M R Ziebell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Physiology and Biophysics, The University at Stony Brook, NY 11794-8661, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology and Biophysics, The University at Stony Brook, NY 11794-8661</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhao, Z G" sort="Zhao, Z G" uniqKey="Zhao Z" first="Z G" last="Zhao">Z G Zhao</name></author><author><name sortKey="Luo, B" sort="Luo, B" uniqKey="Luo B" first="B" last="Luo">B. Luo</name></author><author><name sortKey="Luo, Y" sort="Luo, Y" uniqKey="Luo Y" first="Y" last="Luo">Y. Luo</name></author><author><name sortKey="Turley, E A" sort="Turley, E A" uniqKey="Turley E" first="E A" last="Turley">E A Turley</name></author><author><name sortKey="Prestwich, G D" sort="Prestwich, G D" uniqKey="Prestwich G" first="G D" last="Prestwich">G D Prestwich</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11731299</idno><idno type="pmid">11731299</idno><idno type="doi">10.1016/s1074-5521(01)00078-3</idno><idno type="wicri:Area/PubMed/Corpus">002529</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002529</idno><idno type="wicri:Area/PubMed/Curation">002529</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002529</idno><idno type="wicri:Area/PubMed/Checkpoint">002402</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002402</idno><idno type="wicri:Area/Ncbi/Merge">000117</idno><idno type="wicri:Area/Ncbi/Curation">000117</idno><idno type="wicri:Area/Ncbi/Checkpoint">000117</idno><idno type="wicri:doubleKey">1074-5521:2001:Ziebell M:peptides:that:mimic</idno><idno type="wicri:Area/Main/Merge">003466</idno><idno type="wicri:Area/Main/Curation">003430</idno><idno type="wicri:Area/Main/Exploration">003430</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain.</title><author><name sortKey="Ziebell, M R" sort="Ziebell, M R" uniqKey="Ziebell M" first="M R" last="Ziebell">M R Ziebell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Physiology and Biophysics, The University at Stony Brook, NY 11794-8661, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology and Biophysics, The University at Stony Brook, NY 11794-8661</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhao, Z G" sort="Zhao, Z G" uniqKey="Zhao Z" first="Z G" last="Zhao">Z G Zhao</name></author><author><name sortKey="Luo, B" sort="Luo, B" uniqKey="Luo B" first="B" last="Luo">B. Luo</name></author><author><name sortKey="Luo, Y" sort="Luo, Y" uniqKey="Luo Y" first="Y" last="Luo">Y. Luo</name></author><author><name sortKey="Turley, E A" sort="Turley, E A" uniqKey="Turley E" first="E A" last="Turley">E A Turley</name></author><author><name sortKey="Prestwich, G D" sort="Prestwich, G D" uniqKey="Prestwich G" first="G D" last="Prestwich">G D Prestwich</name></author></analytic><series><title level="j">Chemistry & biology</title><idno type="ISSN">1074-5521</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Binding Sites</term><term>Binding, Competitive</term><term>Extracellular Matrix Proteins (antagonists & inhibitors)</term><term>Extracellular Matrix Proteins (metabolism)</term><term>Glycosaminoglycans (antagonists & inhibitors)</term><term>Glycosaminoglycans (chemistry)</term><term>Humans</term><term>Hyaluronan Receptors (metabolism)</term><term>Hyaluronic Acid (antagonists & inhibitors)</term><term>Hyaluronic Acid (chemistry)</term><term>Ligands</term><term>Models, Molecular</term><term>Molecular Mimicry</term><term>Oligopeptides (chemistry)</term><term>Oligopeptides (metabolism)</term><term>Peptide Library</term><term>Protein Binding</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide hyaluronique ()</term><term>Acide hyaluronique (antagonistes et inhibiteurs)</term><term>Animaux</term><term>Banque de peptides</term><term>Fixation compétitive</term><term>Glycosaminoglycanes ()</term><term>Glycosaminoglycanes (antagonistes et inhibiteurs)</term><term>Humains</term><term>Liaison aux protéines</term><term>Ligands</term><term>Mimétisme moléculaire</term><term>Modèles moléculaires</term><term>Oligopeptides ()</term><term>Oligopeptides (métabolisme)</term><term>Protéines de la matrice extracellulaire (antagonistes et inhibiteurs)</term><term>Protéines de la matrice extracellulaire (métabolisme)</term><term>Relation structure-activité</term><term>Sites de fixation</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Extracellular Matrix Proteins</term><term>Glycosaminoglycans</term><term>Hyaluronic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Glycosaminoglycans</term><term>Hyaluronic Acid</term><term>Oligopeptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Extracellular Matrix Proteins</term><term>Hyaluronan Receptors</term><term>Oligopeptides</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Acide hyaluronique</term><term>Glycosaminoglycanes</term><term>Protéines de la matrice extracellulaire</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Oligopeptides</term><term>Protéines de la matrice extracellulaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Binding Sites</term><term>Binding, Competitive</term><term>Humans</term><term>Ligands</term><term>Models, Molecular</term><term>Molecular Mimicry</term><term>Peptide Library</term><term>Protein Binding</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide hyaluronique</term><term>Animaux</term><term>Banque de peptides</term><term>Fixation compétitive</term><term>Glycosaminoglycanes</term><term>Humains</term><term>Liaison aux protéines</term><term>Ligands</term><term>Mimétisme moléculaire</term><term>Modèles moléculaires</term><term>Oligopeptides</term><term>Relation structure-activité</term><term>Sites de fixation</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hyaluronan (HA) is a non-sulfated glycosaminoglycan (GAG) that promotes motility, adhesion, and proliferation in mammalian cells, as mediated by cell-surface HA receptors. We sought to identify non-carbohydrate ligands that would bind to and activate cell-surface HA receptors. Such analogs could have important therapeutic uses in the treatment of cancer, wound healing, and arthritis, since such ligands would be resistant to degradation by hyaluronidase (HAse).</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Luo, B" sort="Luo, B" uniqKey="Luo B" first="B" last="Luo">B. Luo</name><name sortKey="Luo, Y" sort="Luo, Y" uniqKey="Luo Y" first="Y" last="Luo">Y. Luo</name><name sortKey="Prestwich, G D" sort="Prestwich, G D" uniqKey="Prestwich G" first="G D" last="Prestwich">G D Prestwich</name><name sortKey="Turley, E A" sort="Turley, E A" uniqKey="Turley E" first="E A" last="Turley">E A Turley</name><name sortKey="Zhao, Z G" sort="Zhao, Z G" uniqKey="Zhao Z" first="Z G" last="Zhao">Z G Zhao</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Ziebell, M R" sort="Ziebell, M R" uniqKey="Ziebell M" first="M R" last="Ziebell">M R Ziebell</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003430 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003430 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:11731299
|texte= Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:11731299" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |