An HMG-like protein that can switch a transcriptional activator to a repressor
Identifieur interne : 003369 ( Main/Exploration ); précédent : 003368; suivant : 003370An HMG-like protein that can switch a transcriptional activator to a repressor
Auteurs : Norbert Lehming [États-Unis] ; Dimitris Thanos [États-Unis] ; Joshua M. Brickman [États-Unis] ; Jun Ma ; Tom Maniatis [États-Unis] ; Mark Ptashne [États-Unis]Source :
- Nature [ 0028-0836 ] ; 1994-09-08.
Abstract
ONE protein can activate some genes and repress others in the same cell1. The Drosophila protein Dorsal2 (which, like the human protein NF-B3, is a member of the Rel family of transcriptional activators) activates the twist gene and represses the zen gene in the ventral region of early embryos4,5. Here we describe a Drosophila HMG1 protein, called DSP1 (dorsal switch protein), that converts Dorsal and NF-B from transcriptional activators to repressers. This effect requires a sequence termed a negative regulatory ele-ment (NRE), found adjacent to Dorsal-binding sites in the zen promoter and adjacent to the NF-B-binding site in the human interferon- (IFN-) enhancer68. Previous studies have shown that another type of HMG protein, HMG I(Y), can stimulate NF-B activity9. Thus, the HMG-like proteins DSP1 and HMG I(Y) can determine whether a specific regulator functions as an activator or a repressor of transcription.
Url:
DOI: 10.1038/371175a0
Affiliations:
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Brickman</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USAPresent address: Division of Basic Science Research, Children's Hospital Research Founda-tion, Elland and Bethesda Avenues, Cincinnati, Ohio 45229-2899</wicri:regionArea><orgName type="university">Université Harvard</orgName><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ma, Jun" sort="Ma, Jun" uniqKey="Ma J" first="Jun" last="Ma">Jun Ma</name></author><author><name sortKey="Maniatis, Tom" sort="Maniatis, Tom" uniqKey="Maniatis T" first="Tom" last="Maniatis">Tom Maniatis</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USAPresent address: Division of Basic Science Research, Children's Hospital Research Founda-tion, Elland and Bethesda Avenues, Cincinnati, Ohio 45229-2899</wicri:regionArea><orgName type="university">Université Harvard</orgName><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ptashne, Mark" sort="Ptashne, Mark" uniqKey="Ptashne M" first="Mark" last="Ptashne">Mark Ptashne</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USAPresent address: Division of Basic Science Research, Children's Hospital Research Founda-tion, Elland and Bethesda Avenues, Cincinnati, Ohio 45229-2899</wicri:regionArea><orgName type="university">Université Harvard</orgName><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><imprint><publisher>Nature Publishing Group</publisher><date when="1994-09-08">1994-09-08</date><biblScope unit="vol">371</biblScope><biblScope unit="issue">6493</biblScope><biblScope unit="page" from="175">175</biblScope><biblScope unit="page" to="179">179</biblScope><date type="Copyright" when="2002">2002</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">ONE protein can activate some genes and repress others in the same cell1. The Drosophila protein Dorsal2 (which, like the human protein NF-B3, is a member of the Rel family of transcriptional activators) activates the twist gene and represses the zen gene in the ventral region of early embryos4,5. Here we describe a Drosophila HMG1 protein, called DSP1 (dorsal switch protein), that converts Dorsal and NF-B from transcriptional activators to repressers. This effect requires a sequence termed a negative regulatory ele-ment (NRE), found adjacent to Dorsal-binding sites in the zen promoter and adjacent to the NF-B-binding site in the human interferon- (IFN-) enhancer68. Previous studies have shown that another type of HMG protein, HMG I(Y), can stimulate NF-B activity9. Thus, the HMG-like proteins DSP1 and HMG I(Y) can determine whether a specific regulator functions as an activator or a repressor of transcription.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Cambridge (Massachusetts)</li></settlement><orgName><li>Université Harvard</li></orgName></list><tree><noCountry><name sortKey="Ma, Jun" sort="Ma, Jun" uniqKey="Ma J" first="Jun" last="Ma">Jun Ma</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Lehming, Norbert" sort="Lehming, Norbert" uniqKey="Lehming N" first="Norbert" last="Lehming">Norbert Lehming</name></region><name sortKey="Brickman, Joshua M" sort="Brickman, Joshua M" uniqKey="Brickman J" first="Joshua M." last="Brickman">Joshua M. Brickman</name><name sortKey="Maniatis, Tom" sort="Maniatis, Tom" uniqKey="Maniatis T" first="Tom" last="Maniatis">Tom Maniatis</name><name sortKey="Ptashne, Mark" sort="Ptashne, Mark" uniqKey="Ptashne M" first="Mark" last="Ptashne">Mark Ptashne</name><name sortKey="Thanos, Dimitris" sort="Thanos, Dimitris" uniqKey="Thanos D" first="Dimitris" last="Thanos">Dimitris Thanos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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