A cumulative experience examining the effect of natural and synthetic antimicrobial peptides vs. Chlamydia trachomatis
Identifieur interne : 003182 ( Main/Exploration ); précédent : 003181; suivant : 003183A cumulative experience examining the effect of natural and synthetic antimicrobial peptides vs. Chlamydia trachomatis
Auteurs : B. Yasin [États-Unis] ; M. Pang [États-Unis] ; E. A. Wagar [États-Unis]Source :
- The Journal of Peptide Research [ 1397-002X ] ; 2004-08.
Abstract
Abstract: We tested the activity of 48 structurally diverse antimicrobial peptides against Chlamydia trachomatis, serovar L2. The peptides’ activity against C. trachomatis, serovar L2 was measured in 48‐h McCoy cell shell vial assays. Peptides of 16–20 amino acids were more active than larger peptides, such as defensins. β‐Sheet protegrins, as well as α‐helical peptides such as novispirin (G‐10) were equally active. Enantiomers were as active as native structures. Moderate‐sized circular mini‐defensins were less effective against C. trachomatis. Moderate‐sized cationic peptides may be useful in microbicide preparations designed to prevent chlamydial infection.
Url:
DOI: 10.1111/j.1399-3011.2004.00172.x
Affiliations:
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Yasin</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAR.I. Lehrer, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Pang, M" sort="Pang, M" uniqKey="Pang M" first="M." last="Pang">M. Pang</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAR.I. Lehrer, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Wagar, E A" sort="Wagar, E A" uniqKey="Wagar E" first="E. A." last="Wagar">E. A. Wagar</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAR.I. Lehrer, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Peptide Research</title><title level="j" type="alt">JOURNAL OF PEPTIDE RESEARCH</title><idno type="ISSN">1397-002X</idno><idno type="eISSN">1399-3011</idno><imprint><biblScope unit="vol">64</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="65">65</biblScope><biblScope unit="page" to="71">71</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08">2004-08</date></imprint><idno type="ISSN">1397-002X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1397-002X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We tested the activity of 48 structurally diverse antimicrobial peptides against Chlamydia trachomatis, serovar L2. The peptides’ activity against C. trachomatis, serovar L2 was measured in 48‐h McCoy cell shell vial assays. Peptides of 16–20 amino acids were more active than larger peptides, such as defensins. β‐Sheet protegrins, as well as α‐helical peptides such as novispirin (G‐10) were equally active. Enantiomers were as active as native structures. Moderate‐sized circular mini‐defensins were less effective against C. trachomatis. Moderate‐sized cationic peptides may be useful in microbicide preparations designed to prevent chlamydial infection.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Yasin, B" sort="Yasin, B" uniqKey="Yasin B" first="B." last="Yasin">B. Yasin</name></noRegion><name sortKey="Pang, M" sort="Pang, M" uniqKey="Pang M" first="M." last="Pang">M. Pang</name><name sortKey="Wagar, E A" sort="Wagar, E A" uniqKey="Wagar E" first="E. A." last="Wagar">E. A. 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