LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA†
Identifieur interne : 003089 ( Main/Exploration ); précédent : 003088; suivant : 003090LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA†
Auteurs : Birte Vester [Danemark] ; Jesper Wengel [Danemark]Source :
- Biochemistry [ 0006-2960 ] ; 2004.
Abstract
Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. LNA oligonucleotides display unprecedented hybridization affinity toward complementary single-stranded RNA and complementary single- or double-stranded DNA. Structural studies have shown that LNA oligonucleotides induce A-type (RNA-like) duplex conformations. The wide applicability of LNA oligonucleotides for gene silencing and their use for research and diagnostic purposes are documented in a number of recent reports, some of which are described herein.
Url:
DOI: 10.1021/bi0485732
Affiliations:
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RNA and DNA<ref type="bib" target="#bi0485732AF2">†</ref></title><author><name sortKey="Vester, Birte" sort="Vester, Birte" uniqKey="Vester B" first="Birte" last="Vester">Birte Vester</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Nucleic Acid Center, Department of Biochemistry and Molecular Biology and Department of Chemistry,University of Southern Denmark, Odense University, DK-5230 Odense M</wicri:regionArea><wicri:noRegion>DK-5230 Odense M</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Danemark</country><wicri:regionArea> To whom correspondence should be addressed: Department ofBiochemistry and Molecular Biology, University of Southern Denmark,DK-5230 Odense M</wicri:regionArea><wicri:noRegion>DK-5230 Odense M</wicri:noRegion></affiliation></author><author><name sortKey="Wengel, Jesper" sort="Wengel, Jesper" uniqKey="Wengel J" first="Jesper" last="Wengel">Jesper Wengel</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Nucleic Acid Center, Department of Biochemistry and Molecular Biology and Department of Chemistry,University of Southern Denmark, Odense University, DK-5230 Odense M</wicri:regionArea><wicri:noRegion>DK-5230 Odense M</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Biochemistry</title><title level="j" type="abbrev">Biochemistry</title><idno type="ISSN">0006-2960</idno><idno type="eISSN">1520-4995</idno><imprint><publisher>American Chemical Society</publisher><date type="e-published">2004</date><date type="published">2004</date><biblScope unit="vol">43</biblScope><biblScope unit="issue">42</biblScope><biblScope unit="page" from="13233">13233</biblScope><biblScope unit="page" to="13241">13241</biblScope></imprint><idno type="ISSN">0006-2960</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-2960</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. LNA oligonucleotides display unprecedented hybridization affinity toward complementary single-stranded RNA and complementary single- or double-stranded DNA. Structural studies have shown that LNA oligonucleotides induce A-type (RNA-like) duplex conformations. The wide applicability of LNA oligonucleotides for gene silencing and their use for research and diagnostic purposes are documented in a number of recent reports, some of which are described herein.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Vester, Birte" sort="Vester, Birte" uniqKey="Vester B" first="Birte" last="Vester">Birte Vester</name></noRegion><name sortKey="Vester, Birte" sort="Vester, Birte" uniqKey="Vester B" first="Birte" last="Vester">Birte Vester</name><name sortKey="Wengel, Jesper" sort="Wengel, Jesper" uniqKey="Wengel J" first="Jesper" last="Wengel">Jesper Wengel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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