Aminoglycoside–Nucleic Acid Interactions: The Case for Neomycin
Identifieur interne : 003022 ( Main/Exploration ); précédent : 003021; suivant : 003023Aminoglycoside–Nucleic Acid Interactions: The Case for Neomycin
Auteurs : Dev P. Arya [États-Unis]Source :
- Topics in Current Chemistry [ 0340-1022 ]
Abstract
Abstract: Aminoglycoside antibiotics are bactericidal drugs that have been at the forefront of antimicrobial therapy for almost five decades. The past decade (1990–2000) saw a resurgence in aminoglycoside-based drug development as their chemistry/mechanism of action became better understood. This work, however, had almost exclusively focused on targeting RNA. This review summarizes new developments (past 4–5 years) in aminoglycoside–nucleic acid interactions in the broader context of nucleic acid selectivity, not just RNA. Aminoglycoside binding to A-form nucleic acid structures is discussed, as is the development of novel conjugates for major-minor groove recognition of B-form DNA. Neomycin is chosen as the representative aminoglycoside and is revealed here to be an underutilized scaffold in nucleic acid recognition.
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DOI: 10.1007/b100446
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