Effect of estrogens on the interferon-gamma producing cell population of mouse splenocytes.
Identifieur interne : 002D32 ( Main/Exploration ); précédent : 002D31; suivant : 002D33Effect of estrogens on the interferon-gamma producing cell population of mouse splenocytes.
Auteurs : Mako Nakaya [Japon] ; Hirofumi Tachibana ; Koji YamadaSource :
- Bioscience, biotechnology, and biochemistry [ 0916-8451 ] ; 2006.
Descripteurs français
- KwdFr :
- ARN messager (génétique), Animaux, Cellules cultivées, Interféron gamma (biosynthèse), Interféron gamma (génétique), Mâle, Oestradiol (pharmacologie), Rate (), Rate (métabolisme), Récepteur alpha des oestrogènes (agonistes), Récepteur alpha des oestrogènes (métabolisme), Récepteur bêta des oestrogènes (agonistes), Récepteur bêta des oestrogènes (métabolisme), Régulation de l'expression des gènes (), Régulation de l'expression des gènes (génétique), Souris, Souris de lignée C57BL.
- MESH :
- agonistes : Récepteur alpha des oestrogènes, Récepteur bêta des oestrogènes.
- biosynthèse : Interféron gamma.
- génétique : ARN messager, Interféron gamma, Régulation de l'expression des gènes.
- métabolisme : Rate, Récepteur alpha des oestrogènes, Récepteur bêta des oestrogènes.
- pharmacologie : Oestradiol.
- Animaux, Cellules cultivées, Mâle, Rate, Régulation de l'expression des gènes, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Cells, Cultured, Estradiol (pharmacology), Estrogen Receptor alpha (agonists), Estrogen Receptor alpha (metabolism), Estrogen Receptor beta (agonists), Estrogen Receptor beta (metabolism), Gene Expression Regulation (drug effects), Gene Expression Regulation (genetics), Interferon-gamma (biosynthesis), Interferon-gamma (genetics), Male, Mice, Mice, Inbred C57BL, RNA, Messenger (genetics), Spleen (drug effects), Spleen (metabolism).
- MESH :
- chemical , agonists : Estrogen Receptor alpha, Estrogen Receptor beta.
- chemical , biosynthesis : Interferon-gamma.
- chemical , genetics : Interferon-gamma, RNA, Messenger.
- chemical , metabolism : Estrogen Receptor alpha, Estrogen Receptor beta.
- chemical , pharmacology : Estradiol.
- drug effects : Gene Expression Regulation, Spleen.
- genetics : Gene Expression Regulation.
- metabolism : Spleen.
- Animals, Cells, Cultured, Male, Mice, Mice, Inbred C57BL.
Abstract
We examined the effect of 17beta-estradiol (E2) on the cytokine production by mouse splenocytes. The production of interferon-gamma (IFN-gamma) was enhanced by E2 stimulation. E2 increased the number of cells expressing IFN-gamma and the IFN-gamma mRNA expression level in the cells. There were low- and high-level cells expressing IFN-gamma in the population. The natural killer (NK) cells and NKT cells were the low-level cells expressing IFN-gamma, and the number of these cells was increased by E2 stimulation. In addition, it was suggested that the enhancing effect of IFN-gamma production by E2 was mediated through estrogen receptor (ER) alpha, and ERbeta agonist stimulated IFN-gamma production. ERs are expressed on plasma membrane as well as in nucleus. The ligand specific to plasma membrane-associated ER (mER) enhanced the IFN-gamma production. In conclusion, our results indicated that E2 up-regulated the IFN-gamma production by mediating ERalpha, ERbeta and mERs.
DOI: 10.1271/bbb.70.47
PubMed: 16428820
Affiliations:
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sort="Tachibana, Hirofumi" uniqKey="Tachibana H" first="Hirofumi" last="Tachibana">Hirofumi Tachibana</name></author><author><name sortKey="Yamada, Koji" sort="Yamada, Koji" uniqKey="Yamada K" first="Koji" last="Yamada">Koji Yamada</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16428820</idno><idno type="pmid">16428820</idno><idno type="doi">10.1271/bbb.70.47</idno><idno type="wicri:Area/PubMed/Corpus">002285</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002285</idno><idno type="wicri:Area/PubMed/Curation">002285</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002285</idno><idno type="wicri:Area/PubMed/Checkpoint">002136</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002136</idno><idno type="wicri:Area/Ncbi/Merge">000396</idno><idno 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Kyushu University, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Tachibana, Hirofumi" sort="Tachibana, Hirofumi" uniqKey="Tachibana H" first="Hirofumi" last="Tachibana">Hirofumi Tachibana</name></author><author><name sortKey="Yamada, Koji" sort="Yamada, Koji" uniqKey="Yamada K" first="Koji" last="Yamada">Koji Yamada</name></author></analytic><series><title level="j">Bioscience, biotechnology, and biochemistry</title><idno type="ISSN">0916-8451</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Estradiol (pharmacology)</term><term>Estrogen Receptor alpha 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(agonistes)</term><term>Récepteur bêta des oestrogènes (métabolisme)</term><term>Régulation de l'expression des gènes ()</term><term>Régulation de l'expression des gènes (génétique)</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Estrogen Receptor alpha</term><term>Estrogen Receptor beta</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-gamma</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interferon-gamma</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Estrogen Receptor alpha</term><term>Estrogen Receptor beta</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Estradiol</term></keywords><keywords scheme="MESH" qualifier="agonistes" 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xml:lang="fr"><term>Oestradiol</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Mâle</term><term>Rate</term><term>Régulation de l'expression des gènes</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the effect of 17beta-estradiol (E2) on the cytokine production by mouse splenocytes. The production of interferon-gamma (IFN-gamma) was enhanced by E2 stimulation. E2 increased the number of cells expressing IFN-gamma and the IFN-gamma mRNA expression level in the cells. There were low- and high-level cells expressing IFN-gamma in the population. The natural killer (NK) cells and NKT cells were the low-level cells expressing IFN-gamma, and the number of these cells was increased by E2 stimulation. In addition, it was suggested that the enhancing effect of IFN-gamma production by E2 was mediated through estrogen receptor (ER) alpha, and ERbeta agonist stimulated IFN-gamma production. ERs are expressed on plasma membrane as well as in nucleus. The ligand specific to plasma membrane-associated ER (mER) enhanced the IFN-gamma production. In conclusion, our results indicated that E2 up-regulated the IFN-gamma production by mediating ERalpha, ERbeta and mERs.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Kyūshū</li><li>Préfecture de Fukuoka</li></region><settlement><li>Fukuoka</li></settlement><orgName><li>Université de Kyūshū</li></orgName></list><tree><noCountry><name sortKey="Tachibana, Hirofumi" sort="Tachibana, Hirofumi" uniqKey="Tachibana H" first="Hirofumi" last="Tachibana">Hirofumi Tachibana</name><name sortKey="Yamada, Koji" sort="Yamada, Koji" uniqKey="Yamada K" first="Koji" last="Yamada">Koji Yamada</name></noCountry><country name="Japon"><region name="Kyūshū"><name sortKey="Nakaya, Mako" sort="Nakaya, Mako" uniqKey="Nakaya M" first="Mako" last="Nakaya">Mako Nakaya</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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