RNA self-processing towards changed topology and sequence oligomerization
Identifieur interne : 002C33 ( Main/Exploration ); précédent : 002C32; suivant : 002C34RNA self-processing towards changed topology and sequence oligomerization
Auteurs : Stefan Pieper [Allemagne] ; Stéphanie Vauléon [Allemagne] ; Sabine Müller [Allemagne]Source :
- Biological Chemistry [ 14374315 ] ; 2007.
English descriptors
- Teeft :
- Alkaline phosphatase, Chem, Cleavage, Conformation, Cyclic, Cyclic dimer, Denaturing polyacrylamide, Early life forms, Further analysis, Genome size, Hairpin, Hairpin ribozyme, Hairpin ribozymes, Hairpin structure, Higher mobility, Higher structures, Intermolecular reactions, Internal equilibrium, Ligation, Ligation reactions, Magnesium chloride, Monomeric building blocks, Phosphodiester bonds, Prebiotic chemistry, Reaction analysis, Reaction buffer, Reaction cycle, Reaction mixture, Reasonable explanation, Reversible chemistry, Ribozyme, Ribozymes, Sequence space, Stephanie vauleon, Structural control, Transcription, Transcription mixture, Transcription product, Twin ribozyme, Upper bands, World scenarios.
Abstract
Reversible chemistry, allowing for chain-forming as well as chain-breaking steps, is important for biological self-organization. In this context, ribozymes, catalyzing both RNA cleavage and ligation, may have significantly contributed to extending the sequence space and length of RNA molecules in early life forms. Here we present an engineered RNA that self-processes by passing through a number of cleavage and ligation steps. Intermolecular reactions compete with intramolecular reactions, resulting in a variety of products. Our results demonstrate that RNA can undergo self-oligomerization, which may have been important for extending the RNA genome size in RNA world scenarios.
Url:
DOI: 10.1515/BC.2007.067
Affiliations:
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In this context, ribozymes, catalyzing both RNA cleavage and ligation, may have significantly contributed to extending the sequence space and length of RNA molecules in early life forms. Here we present an engineered RNA that self-processes by passing through a number of cleavage and ligation steps. Intermolecular reactions compete with intramolecular reactions, resulting in a variety of products. Our results demonstrate that RNA can undergo self-oligomerization, which may have been important for extending the RNA genome size in RNA world scenarios.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Pieper, Stefan" sort="Pieper, Stefan" uniqKey="Pieper S" first="Stefan" last="Pieper">Stefan Pieper</name></region><name sortKey="Muller, Sabine" sort="Muller, Sabine" uniqKey="Muller S" first="Sabine" last="Müller">Sabine Müller</name><name sortKey="Vauleon, Stephanie" sort="Vauleon, Stephanie" uniqKey="Vauleon S" first="Stéphanie" last="Vauléon">Stéphanie Vauléon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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