Concerted Evolution of Vertebrate CCR2 and CCR5 Genes and the Origin of a Recombinant Equine CCR5/2 Gene
Identifieur interne : 002A41 ( Main/Exploration ); précédent : 002A40; suivant : 002A42Concerted Evolution of Vertebrate CCR2 and CCR5 Genes and the Origin of a Recombinant Equine CCR5/2 Gene
Auteurs : Andrey A. Perelygin [États-Unis] ; Andrey A. Zharkikh [États-Unis] ; Natalia M. Astakhova [États-Unis] ; Teri L. Lear [États-Unis] ; Margo A. Brinton [États-Unis]Source :
- Journal of Heredity [ 0022-1503 ] ; 2008.
Abstract
Chemokine receptors (CCRs) play an essential role in the initiation of an innate immune host response. Several of these receptors have been shown to modulate the outcome of viral infections. The recent availability of complete genome sequences from a number of species provides a unique opportunity to analyze the evolution of the CCR genes. A phylogenetic analysis revealed that the CCR2 gene evolved in concert with the paralogous CCR5 gene, but not with another paralogous gene, CCR3, in the opossum, platypus, rabbit, guinea pig, cat, and rodent lineages. In addition, evidence of concerted evolution of the CCR2 and CCR5 genes was observed in chicken and lizard genomes. A unique CCR5/2 gene that originated by unequal crossing over between the CCR2 and CCR5 genes was detected in the domestic horse. The CCR2, CCR5, and CCR5/2 genes were mapped to ECA16q21 using fluorescent in situ hybridization (FISH). Single-nucleotide polymorphisms identified in the equine CCR5 gene and characterized within 5 horse breeds provide haplotype markers for future case/control studies investigating the genetic bases of horse susceptibility to infectious diseases.
Url:
DOI: 10.1093/jhered/esn029
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001D53
- to stream Istex, to step Curation: 001D53
- to stream Istex, to step Checkpoint: 000755
- to stream Main, to step Merge: 002A67
- to stream Main, to step Curation: 002A41
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Concerted Evolution of Vertebrate CCR2 and CCR5 Genes and the Origin of a Recombinant Equine CCR5/2 Gene</title><author><name sortKey="Perelygin, Andrey A" sort="Perelygin, Andrey A" uniqKey="Perelygin A" first="Andrey A." last="Perelygin">Andrey A. Perelygin</name></author><author><name sortKey="Zharkikh, Andrey A" sort="Zharkikh, Andrey A" uniqKey="Zharkikh A" first="Andrey A." last="Zharkikh">Andrey A. Zharkikh</name></author><author><name sortKey="Astakhova, Natalia M" sort="Astakhova, Natalia M" uniqKey="Astakhova N" first="Natalia M." last="Astakhova">Natalia M. Astakhova</name></author><author><name sortKey="Lear, Teri L" sort="Lear, Teri L" uniqKey="Lear T" first="Teri L." last="Lear">Teri L. Lear</name></author><author><name sortKey="Brinton, Margo A" sort="Brinton, Margo A" uniqKey="Brinton M" first="Margo A." last="Brinton">Margo A. Brinton</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9CFCB5745CC9376362B059332BEDE2DC5C542646</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1093/jhered/esn029</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-GLMWQN8V-P/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001D53</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D53</idno><idno type="wicri:Area/Istex/Curation">001D53</idno><idno type="wicri:Area/Istex/Checkpoint">000755</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000755</idno><idno type="wicri:doubleKey">0022-1503:2008:Perelygin A:concerted:evolution:of</idno><idno type="wicri:Area/Main/Merge">002A67</idno><idno type="wicri:Area/Main/Curation">002A41</idno><idno type="wicri:Area/Main/Exploration">002A41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Concerted Evolution of Vertebrate <hi rend="italic">CCR2</hi> and <hi rend="italic">CCR5</hi> Genes and the Origin of a Recombinant Equine <hi rend="italic">CCR5/2</hi> Gene</title><author><name sortKey="Perelygin, Andrey A" sort="Perelygin, Andrey A" uniqKey="Perelygin A" first="Andrey A." last="Perelygin">Andrey A. Perelygin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>From the Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302 (Perelygin, Astakhova, and Brinton); the Bioinformatics Department, Myriad Genetics, Inc., Salt Lake City, 320 Wakara Way, UT 84108 (Zharkikh); and the Department of Veterinary Science, University of Kentucky, 108 Maxwell H. Gluck Equine Research Center, Lexington</wicri:cityArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Zharkikh, Andrey A" sort="Zharkikh, Andrey A" uniqKey="Zharkikh A" first="Andrey A." last="Zharkikh">Andrey A. Zharkikh</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>From the Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302 (Perelygin, Astakhova, and Brinton); the Bioinformatics Department, Myriad Genetics, Inc., Salt Lake City, 320 Wakara Way, UT 84108 (Zharkikh); and the Department of Veterinary Science, University of Kentucky, 108 Maxwell H. Gluck Equine Research Center, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Astakhova, Natalia M" sort="Astakhova, Natalia M" uniqKey="Astakhova N" first="Natalia M." last="Astakhova">Natalia M. Astakhova</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>From the Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302 (Perelygin, Astakhova, and Brinton); the Bioinformatics Department, Myriad Genetics, Inc., Salt Lake City, 320 Wakara Way, UT 84108 (Zharkikh); and the Department of Veterinary Science, University of Kentucky, 108 Maxwell H. Gluck Equine Research Center, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Lear, Teri L" sort="Lear, Teri L" uniqKey="Lear T" first="Teri L." last="Lear">Teri L. Lear</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>From the Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302 (Perelygin, Astakhova, and Brinton); the Bioinformatics Department, Myriad Genetics, Inc., Salt Lake City, 320 Wakara Way, UT 84108 (Zharkikh); and the Department of Veterinary Science, University of Kentucky, 108 Maxwell H. Gluck Equine Research Center, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Brinton, Margo A" sort="Brinton, Margo A" uniqKey="Brinton M" first="Margo A." last="Brinton">Margo A. Brinton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>From the Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302 (Perelygin, Astakhova, and Brinton); the Bioinformatics Department, Myriad Genetics, Inc., Salt Lake City, 320 Wakara Way, UT 84108 (Zharkikh); and the Department of Veterinary Science, University of Kentucky, 108 Maxwell H. Gluck Equine Research Center, Lexington</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Heredity</title><idno type="eISSN">1465-7333</idno><idno type="ISSN">0022-1503</idno><imprint><publisher>Oxford University Press</publisher><date>2008</date><date type="e-published">2008</date><biblScope unit="vol">99</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="500">500</biblScope><biblScope unit="page" to="511">511</biblScope></imprint><idno type="ISSN">0022-1503</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1503</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Chemokine receptors (CCRs) play an essential role in the initiation of an innate immune host response. Several of these receptors have been shown to modulate the outcome of viral infections. The recent availability of complete genome sequences from a number of species provides a unique opportunity to analyze the evolution of the CCR genes. A phylogenetic analysis revealed that the CCR2 gene evolved in concert with the paralogous CCR5 gene, but not with another paralogous gene, CCR3, in the opossum, platypus, rabbit, guinea pig, cat, and rodent lineages. In addition, evidence of concerted evolution of the CCR2 and CCR5 genes was observed in chicken and lizard genomes. A unique CCR5/2 gene that originated by unequal crossing over between the CCR2 and CCR5 genes was detected in the domestic horse. The CCR2, CCR5, and CCR5/2 genes were mapped to ECA16q21 using fluorescent in situ hybridization (FISH). Single-nucleotide polymorphisms identified in the equine CCR5 gene and characterized within 5 horse breeds provide haplotype markers for future case/control studies investigating the genetic bases of horse susceptibility to infectious diseases.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Kentucky</li></region></list><tree><country name="États-Unis"><region name="Kentucky"><name sortKey="Perelygin, Andrey A" sort="Perelygin, Andrey A" uniqKey="Perelygin A" first="Andrey A." last="Perelygin">Andrey A. Perelygin</name></region><name sortKey="Astakhova, Natalia M" sort="Astakhova, Natalia M" uniqKey="Astakhova N" first="Natalia M." last="Astakhova">Natalia M. Astakhova</name><name sortKey="Brinton, Margo A" sort="Brinton, Margo A" uniqKey="Brinton M" first="Margo A." last="Brinton">Margo A. Brinton</name><name sortKey="Lear, Teri L" sort="Lear, Teri L" uniqKey="Lear T" first="Teri L." last="Lear">Teri L. Lear</name><name sortKey="Perelygin, Andrey A" sort="Perelygin, Andrey A" uniqKey="Perelygin A" first="Andrey A." last="Perelygin">Andrey A. Perelygin</name><name sortKey="Zharkikh, Andrey A" sort="Zharkikh, Andrey A" uniqKey="Zharkikh A" first="Andrey A." last="Zharkikh">Andrey A. Zharkikh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A41 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A41 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9CFCB5745CC9376362B059332BEDE2DC5C542646
|texte= Concerted Evolution of Vertebrate CCR2 and CCR5 Genes and the Origin of a Recombinant Equine CCR5/2 Gene
}}
| This area was generated with Dilib version V0.6.33. |  |