Regeneration of abdominal wall musculofascial defects by a human acellular collagen matrix.
Identifieur interne : 002956 ( Main/Exploration ); précédent : 002955; suivant : 002957Regeneration of abdominal wall musculofascial defects by a human acellular collagen matrix.
Auteurs : Denis Dufrane [Belgique] ; Michel Mourad ; Mathieu Van Steenberghe ; Rose-Marie Goebbels ; Pierre GianelloSource :
- Biomaterials [ 0142-9612 ] ; 2008.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Collagène (usage thérapeutique), Facteurs temps, Humains, Immunohistochimie, Matrice extracellulaire (), Muscles squelettiques (), Muscles squelettiques (malformations), Muscles squelettiques (physiologie), Mâle, Paroi abdominale, Rat Wistar, Rats, Régénération (physiologie), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de suivi.
- MESH :
- malformations : Muscles squelettiques.
- physiologie : Muscles squelettiques, Régénération.
- usage thérapeutique : Collagène.
- Adulte, Adulte d'âge moyen, Animaux, Facteurs temps, Humains, Immunohistochimie, Matrice extracellulaire, Muscles squelettiques, Mâle, Paroi abdominale, Rat Wistar, Rats, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de suivi.
English descriptors
- KwdEn :
- Abdominal Wall, Adult, Aged, Aged, 80 and over, Animals, Collagen (therapeutic use), Extracellular Matrix (chemistry), Follow-Up Studies, Humans, Immunohistochemistry, Male, Middle Aged, Muscle, Skeletal (abnormalities), Muscle, Skeletal (physiology), Muscle, Skeletal (surgery), Rats, Rats, Wistar, Regeneration (physiology), Time Factors, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Collagen.
- abnormalities : Muscle, Skeletal.
- chemistry : Extracellular Matrix.
- physiology : Muscle, Skeletal, Regeneration.
- surgery : Muscle, Skeletal.
- Abdominal Wall, Adult, Aged, Aged, 80 and over, Animals, Follow-Up Studies, Humans, Immunohistochemistry, Male, Middle Aged, Rats, Rats, Wistar, Time Factors, Treatment Outcome.
Abstract
This work studied the reconstruction of an abdominal wall defect by a human acellular collagen matrix. The abdominal wall defect was cured in 40 rats by implanting (i) polypropylene (Pro), (ii) polyester (Mers) meshes, and (iii) human acellular collagen matrix with two orientations: fibres in parallel (fascia lata longitudinal [FLL]) or perpendicular (fascia lata transversal [FLT]) to native rats' abdominal walls. Hernia recurrence, adhesions, and histology (for inflammation and remodelling) were assessed at 4 and 8 weeks after implantation. Two large abdominal eventrations were cured by a human acellular matrix in human patients. A higher hernia recurrence rate was observed for rats transplanted with FLL than with FLT/Pro/Mers at 4 and 8 weeks after implantation. A lower adhesion rate was achieved for FLL/FLT than for Pro/Mers meshes (p<0.05). A decrease in immunologic cell infiltrations in FLL/FLT was observed between day 30 and day 60 (p<0.05). Collagen, elastin, and muscular tissues were found only in FLL/FLT matrix; a weaker muscular cell infiltration for FLL occurred at 8 weeks. Human abdominal eventrations were totally cured by using FLT as confirmed by computed tomography scanning at 12 and 16 months after implantation. In conclusion, human acellular collagen matrix, placed in an FLT position, can induce an abdominal wall reconstitution without adhesions and hernia recurrence.
DOI: 10.1016/j.biomaterials.2008.01.027
PubMed: 18281088
Affiliations:
- Belgique
- Province du Brabant wallon, Région wallonne
- Louvain-la-Neuve
- Université catholique de Louvain
Links toward previous steps (curation, corpus...)
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- to stream PubMed, to step Curation: 002121
- to stream PubMed, to step Checkpoint: 001F64
- to stream Ncbi, to step Merge: 000585
- to stream Ncbi, to step Curation: 000585
- to stream Ncbi, to step Checkpoint: 000585
- to stream Main, to step Merge: 002982
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Le document en format XML
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Steenberghe, Mathieu" uniqKey="Van Steenberghe M" first="Mathieu" last="Van Steenberghe">Mathieu Van Steenberghe</name></author><author><name sortKey="Goebbels, Rose Marie" sort="Goebbels, Rose Marie" uniqKey="Goebbels R" first="Rose-Marie" last="Goebbels">Rose-Marie Goebbels</name></author><author><name sortKey="Gianello, Pierre" sort="Gianello, Pierre" uniqKey="Gianello P" first="Pierre" last="Gianello">Pierre Gianello</name></author></analytic><series><title level="j">Biomaterials</title><idno type="ISSN">0142-9612</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abdominal Wall</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Collagen (therapeutic use)</term><term>Extracellular Matrix (chemistry)</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Muscle, Skeletal (abnormalities)</term><term>Muscle, Skeletal (physiology)</term><term>Muscle, Skeletal (surgery)</term><term>Rats</term><term>Rats, Wistar</term><term>Regeneration (physiology)</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Collagène (usage thérapeutique)</term><term>Facteurs temps</term><term>Humains</term><term>Immunohistochimie</term><term>Matrice extracellulaire ()</term><term>Muscles squelettiques ()</term><term>Muscles squelettiques (malformations)</term><term>Muscles squelettiques (physiologie)</term><term>Mâle</term><term>Paroi abdominale</term><term>Rat Wistar</term><term>Rats</term><term>Régénération (physiologie)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Collagen</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Extracellular Matrix</term></keywords><keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Muscles squelettiques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Muscles squelettiques</term><term>Régénération</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Muscle, Skeletal</term><term>Regeneration</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Collagène</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Abdominal Wall</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Rats</term><term>Rats, Wistar</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Facteurs temps</term><term>Humains</term><term>Immunohistochimie</term><term>Matrice extracellulaire</term><term>Muscles squelettiques</term><term>Mâle</term><term>Paroi abdominale</term><term>Rat Wistar</term><term>Rats</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This work studied the reconstruction of an abdominal wall defect by a human acellular collagen matrix. The abdominal wall defect was cured in 40 rats by implanting (i) polypropylene (Pro), (ii) polyester (Mers) meshes, and (iii) human acellular collagen matrix with two orientations: fibres in parallel (fascia lata longitudinal [FLL]) or perpendicular (fascia lata transversal [FLT]) to native rats' abdominal walls. Hernia recurrence, adhesions, and histology (for inflammation and remodelling) were assessed at 4 and 8 weeks after implantation. Two large abdominal eventrations were cured by a human acellular matrix in human patients. A higher hernia recurrence rate was observed for rats transplanted with FLL than with FLT/Pro/Mers at 4 and 8 weeks after implantation. A lower adhesion rate was achieved for FLL/FLT than for Pro/Mers meshes (p<0.05). A decrease in immunologic cell infiltrations in FLL/FLT was observed between day 30 and day 60 (p<0.05). Collagen, elastin, and muscular tissues were found only in FLL/FLT matrix; a weaker muscular cell infiltration for FLL occurred at 8 weeks. Human abdominal eventrations were totally cured by using FLT as confirmed by computed tomography scanning at 12 and 16 months after implantation. In conclusion, human acellular collagen matrix, placed in an FLT position, can induce an abdominal wall reconstitution without adhesions and hernia recurrence.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Province du Brabant wallon</li><li>Région wallonne</li></region><settlement><li>Louvain-la-Neuve</li></settlement><orgName><li>Université catholique de Louvain</li></orgName></list><tree><noCountry><name sortKey="Gianello, Pierre" sort="Gianello, Pierre" uniqKey="Gianello P" first="Pierre" last="Gianello">Pierre Gianello</name><name sortKey="Goebbels, Rose Marie" sort="Goebbels, Rose Marie" uniqKey="Goebbels R" first="Rose-Marie" last="Goebbels">Rose-Marie Goebbels</name><name sortKey="Mourad, Michel" sort="Mourad, Michel" uniqKey="Mourad M" first="Michel" last="Mourad">Michel Mourad</name><name sortKey="Van Steenberghe, Mathieu" sort="Van Steenberghe, Mathieu" uniqKey="Van Steenberghe M" first="Mathieu" last="Van Steenberghe">Mathieu Van Steenberghe</name></noCountry><country name="Belgique"><region name="Région wallonne"><name sortKey="Dufrane, Denis" sort="Dufrane, Denis" uniqKey="Dufrane D" first="Denis" last="Dufrane">Denis Dufrane</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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