C4 protein of Beet severe curly top virus is a pathomorphogenetic factor in Arabidopsis
Identifieur interne : 002741 ( Main/Exploration ); précédent : 002740; suivant : 002742C4 protein of Beet severe curly top virus is a pathomorphogenetic factor in Arabidopsis
Auteurs : Jungan Park [Corée du Sud] ; Hyun-Sik Hwang [Corée du Sud] ; Kenneth J. Buckley [États-Unis] ; Jong-Bum Park [Corée du Sud] ; Chung-Kyun Auh [Corée du Sud] ; Dong-Giun Kim [Corée du Sud] ; Sukchan Lee [Corée du Sud, États-Unis] ; Keith R. Davis [États-Unis]Source :
- Plant Cell Reports [ 0721-7714 ] ; 2010-12-01.
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Abstract
Abstract: The Curtovirus C4 protein is required for symptom development during infection of Arabidopsis. Transgenic Arabidopsis plants expressing C4 from either Beet curly top virus or Beet severe curly top virus produced phenotypes that were similar to symptoms seen during infection with wild-type viruses. The pseudosymptoms caused by C4 protein alone were novel to transgenic Arabidopsis and included bumpy trichomes, severe enations, disorientation of vascular bundles and stomata, swelling, callus-like structure formation, and twisted siliques. C4 induced abnormal cell division and altered cell fate in a variety of tissues depending on the C4 expression level. C4 protein expression increased the expression levels of cell-cycle-related genes CYCs, CDKs and PCNA, and suppressed ICK1 and the retinoblastoma-related gene RBR1, resulting in activation of host cell division. These results suggest that the Curtovirus C4 proteins are involved actively in host cell-cycle regulation to recruit host factors for virus replication and symptom development.
Url:
DOI: 10.1007/s00299-010-0923-8
Affiliations:
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Davis</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Owensboro Cancer Research Program, Mitchell Memorial Cancer Center, 42303, Owensboro, KY</wicri:regionArea><wicri:noRegion>KY</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Plant Cell Reports</title><title level="j" type="abbrev">Plant Cell Rep</title><idno type="ISSN">0721-7714</idno><idno type="eISSN">1432-203X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2010-12-01">2010-12-01</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1377">1377</biblScope><biblScope unit="page" to="1389">1389</biblScope></imprint><idno type="ISSN">0721-7714</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0721-7714</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arabidopsis</term><term>BSCTV C4</term><term>Cell cycle</term><term>Pathomorphogenesis</term><term>Transgenic plants</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The Curtovirus C4 protein is required for symptom development during infection of Arabidopsis. Transgenic Arabidopsis plants expressing C4 from either Beet curly top virus or Beet severe curly top virus produced phenotypes that were similar to symptoms seen during infection with wild-type viruses. The pseudosymptoms caused by C4 protein alone were novel to transgenic Arabidopsis and included bumpy trichomes, severe enations, disorientation of vascular bundles and stomata, swelling, callus-like structure formation, and twisted siliques. C4 induced abnormal cell division and altered cell fate in a variety of tissues depending on the C4 expression level. C4 protein expression increased the expression levels of cell-cycle-related genes CYCs, CDKs and PCNA, and suppressed ICK1 and the retinoblastoma-related gene RBR1, resulting in activation of host cell division. These results suggest that the Curtovirus C4 proteins are involved actively in host cell-cycle regulation to recruit host factors for virus replication and symptom development.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Park, Jungan" sort="Park, Jungan" uniqKey="Park J" first="Jungan" last="Park">Jungan Park</name></noRegion><name sortKey="Auh, Chung Kyun" sort="Auh, Chung Kyun" uniqKey="Auh C" first="Chung-Kyun" last="Auh">Chung-Kyun Auh</name><name sortKey="Hwang, Hyun Sik" sort="Hwang, Hyun Sik" uniqKey="Hwang H" first="Hyun-Sik" last="Hwang">Hyun-Sik Hwang</name><name sortKey="Kim, Dong Giun" sort="Kim, Dong Giun" uniqKey="Kim D" first="Dong-Giun" last="Kim">Dong-Giun Kim</name><name sortKey="Lee, Sukchan" sort="Lee, Sukchan" uniqKey="Lee S" first="Sukchan" last="Lee">Sukchan Lee</name><name sortKey="Park, Jong Bum" sort="Park, Jong Bum" uniqKey="Park J" first="Jong-Bum" last="Park">Jong-Bum Park</name></country><country name="États-Unis"><noRegion><name sortKey="Buckley, Kenneth J" sort="Buckley, Kenneth J" uniqKey="Buckley K" first="Kenneth J." last="Buckley">Kenneth J. 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